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The map label for this gene is qacF [H]

Identifier: 59713445

GI number: 59713445

Start: 294325

End: 294654

Strand: Reverse

Name: qacF [H]

Synonym: VF_A0262

Alternate gene names: 59713445

Gene position: 294654-294325 (Counterclockwise)

Preceding gene: 59713446

Following gene: 59713444

Centisome position: 22.15

GC content: 37.58

Gene sequence:

>330_bases
ATGGGATGGCTTTTTCTTCTTCTTGCAGTTGCTTCAGAAGCATTTTCACACGTTGCACTTAAAGCAACCGATGGTCTTTC
ACACCTAATACCAAATGTCATTGTAATTACTGGTCATCTAGGTGCTTTTTATTTTCTTAGTCAAGCAATGAAGACATTAC
CTGTAGGAATTGCTCACGCATCATGGGCGGGATTAGCAATCATTGCGGTAACGCTGATTTCAAGTGCATTTTATCATCAA
CATTTAGACAATAAAATTTGGTTAGGTATTGGATTTATCAGTATTGGCATTGCGATAATTAACCTATCATCTACGCCTCA
CGTACATTAA

Upstream 100 bases:

>100_bases
CACTCACGTAAAAGTAATTAATTCTATTAGCTATTATCATTAAATTTGAAATAACTATACTACACCTACTTACCAACACC
GCTAAATAGGAATTAATAAA

Downstream 100 bases:

>100_bases
ACACCCTAATTGTTATAATTTATGCAAAATTTACAAGCTGAAAAACATTTCTATTATATTTTCTTGCTATCATGTAAACA
TAAATACAATAACTTAAATA

Product: quaternary ammonium compound-resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MGWLFLLLAVASEAFSHVALKATDGLSHLIPNVIVITGHLGAFYFLSQAMKTLPVGIAHASWAGLAIIAVTLISSAFYHQ
HLDNKIWLGIGFISIGIAIINLSSTPHVH

Sequences:

>Translated_109_residues
MGWLFLLLAVASEAFSHVALKATDGLSHLIPNVIVITGHLGAFYFLSQAMKTLPVGIAHASWAGLAIIAVTLISSAFYHQ
HLDNKIWLGIGFISIGIAIINLSSTPHVH
>Mature_108_residues
GWLFLLLAVASEAFSHVALKATDGLSHLIPNVIVITGHLGAFYFLSQAMKTLPVGIAHASWAGLAIIAVTLISSAFYHQH
LDNKIWLGIGFISIGIAIINLSSTPHVH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=101, Percent_Identity=35.6435643564356, Blast_Score=70, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11640; Mature: 11509

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWLFLLLAVASEAFSHVALKATDGLSHLIPNVIVITGHLGAFYFLSQAMKTLPVGIAHA
CHHHHHHHHHHHHHHHHHHEECCCCHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCHH
SWAGLAIIAVTLISSAFYHQHLDNKIWLGIGFISIGIAIINLSSTPHVH
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure 
GWLFLLLAVASEAFSHVALKATDGLSHLIPNVIVITGHLGAFYFLSQAMKTLPVGIAHA
HHHHHHHHHHHHHHHHHHEECCCCHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCHH
SWAGLAIIAVTLISSAFYHQHLDNKIWLGIGFISIGIAIINLSSTPHVH
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]