Click here to switch to the map view.

The map label for this gene is glpG [H]

Identifier: 59713054

GI number: 59713054

Start: 2748178

End: 2749020

Strand: Reverse

Name: glpG [H]

Synonym: VF_2447

Alternate gene names: 59713054

Gene position: 2749020-2748178 (Counterclockwise)

Preceding gene: 59713055

Following gene: 59713052

Centisome position: 94.87

GC content: 39.74

Gene sequence:

>843_bases
ATGCAAAGATTAATCGCATTATCAAACCCTAGAGCAGGACAAGCATTCATTGATTATATGGCATCAAGACATATCGATAT
CAGAATGATGCCAGAAGGGGATGGGCAGTTTGCTTTATGGGTTGTTTCTGATGATGCTTATTTACTGGAAGTCGAATCAG
AATTACAGGCATTTTTACGTAACCCTAATGATGTTAAATACCAATCAGCATCATGGGATATGGCGGATACACGAACAGCA
AAGTTTGCATATGGTTCGCCTAATCTCATGAAAATGATCAAAGCTAAAGCTGGGATCTTTACGTTGTCGATAATGCTTGT
GTGTATTGTGATTTTTGCTTTGCAACAGTTAGGGTGGAATAACTCGATTTTCCAAGCGTTACACTTTCCTGCCTATCAAG
GACAGAGTGTTGAAGTATGGCGCTGGTTCTCACATGCATTGCTGCACTTTTCTGCGACACATATAATTTTTAATTTATTG
TGGTGGTGGCAGCTAGGCGGGGATATTGAATTACGATTAGGTCGAACTAAGTTAGTACAGCTGTTTTTATTTTCAGCGCT
GTTTTCTGGTTTAGGTCAGTTCTGGGTTGAAGGTGCTAACTTTGGTGGGCTATCTGGTGTGGTGTATGCGTTACTCGGTT
ACTCTTGGTTTATTGGCTGGTTAGCGCCAGAGAAAGGTATTTCCGTATCTAAACCAATAGTTGGTTTTATGCTTGTTTGG
CTAATTTTAGGTTATGTACAACCTTTTATGGCAATTGCAAATACAGCGCATTTAGCAGGCTTAATCACCGGATGTATAAT
TGCTGGGATTGATAGTCGCTTTAGAAAATCTTCATTGAGTTAA

Upstream 100 bases:

>100_bases
TCAGTATTTAGTGAATCAAGGCTATGAAGAAGTTTATAGTGTTGATGGTGGATTTGAAGGTTGGCATAAAGCAGGGTTAC
CTGTGGAGAAATAAAAGCAT

Downstream 100 bases:

>100_bases
AAAAAATGAGCGAGGTAATGATTACCTCGCTCATTTTATATTGACGTAGATAAATAAAAATATCTAACGTAAAAATAGTT
ATTGATAAATGTATTTGGTA

Product: intramembrane serine protease

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MQRLIALSNPRAGQAFIDYMASRHIDIRMMPEGDGQFALWVVSDDAYLLEVESELQAFLRNPNDVKYQSASWDMADTRTA
KFAYGSPNLMKMIKAKAGIFTLSIMLVCIVIFALQQLGWNNSIFQALHFPAYQGQSVEVWRWFSHALLHFSATHIIFNLL
WWWQLGGDIELRLGRTKLVQLFLFSALFSGLGQFWVEGANFGGLSGVVYALLGYSWFIGWLAPEKGISVSKPIVGFMLVW
LILGYVQPFMAIANTAHLAGLITGCIIAGIDSRFRKSSLS

Sequences:

>Translated_280_residues
MQRLIALSNPRAGQAFIDYMASRHIDIRMMPEGDGQFALWVVSDDAYLLEVESELQAFLRNPNDVKYQSASWDMADTRTA
KFAYGSPNLMKMIKAKAGIFTLSIMLVCIVIFALQQLGWNNSIFQALHFPAYQGQSVEVWRWFSHALLHFSATHIIFNLL
WWWQLGGDIELRLGRTKLVQLFLFSALFSGLGQFWVEGANFGGLSGVVYALLGYSWFIGWLAPEKGISVSKPIVGFMLVW
LILGYVQPFMAIANTAHLAGLITGCIIAGIDSRFRKSSLS
>Mature_280_residues
MQRLIALSNPRAGQAFIDYMASRHIDIRMMPEGDGQFALWVVSDDAYLLEVESELQAFLRNPNDVKYQSASWDMADTRTA
KFAYGSPNLMKMIKAKAGIFTLSIMLVCIVIFALQQLGWNNSIFQALHFPAYQGQSVEVWRWFSHALLHFSATHIIFNLL
WWWQLGGDIELRLGRTKLVQLFLFSALFSGLGQFWVEGANFGGLSGVVYALLGYSWFIGWLAPEKGISVSKPIVGFMLVW
LILGYVQPFMAIANTAHLAGLITGCIIAGIDSRFRKSSLS

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

Organism=Escherichia coli, GI48994938, Length=280, Percent_Identity=40, Blast_Score=195, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 31444; Mature: 31444

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLIALSNPRAGQAFIDYMASRHIDIRMMPEGDGQFALWVVSDDAYLLEVESELQAFLR
CCCEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCEEEEEEHHHHHHHHC
NPNDVKYQSASWDMADTRTAKFAYGSPNLMKMIKAKAGIFTLSIMLVCIVIFALQQLGWN
CCCCCEEECCCCCCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
NSIFQALHFPAYQGQSVEVWRWFSHALLHFSATHIIFNLLWWWQLGGDIELRLGRTKLVQ
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHH
LFLFSALFSGLGQFWVEGANFGGLSGVVYALLGYSWFIGWLAPEKGISVSKPIVGFMLVW
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LILGYVQPFMAIANTAHLAGLITGCIIAGIDSRFRKSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
>Mature Secondary Structure
MQRLIALSNPRAGQAFIDYMASRHIDIRMMPEGDGQFALWVVSDDAYLLEVESELQAFLR
CCCEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCEEEEEEHHHHHHHHC
NPNDVKYQSASWDMADTRTAKFAYGSPNLMKMIKAKAGIFTLSIMLVCIVIFALQQLGWN
CCCCCEEECCCCCCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
NSIFQALHFPAYQGQSVEVWRWFSHALLHFSATHIIFNLLWWWQLGGDIELRLGRTKLVQ
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHH
LFLFSALFSGLGQFWVEGANFGGLSGVVYALLGYSWFIGWLAPEKGISVSKPIVGFMLVW
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LILGYVQPFMAIANTAHLAGLITGCIIAGIDSRFRKSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA