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The map label for this gene is cpxR [H]

Identifier: 59712950

GI number: 59712950

Start: 2632004

End: 2632687

Strand: Direct

Name: cpxR [H]

Synonym: VF_2343

Alternate gene names: 59712950

Gene position: 2632004-2632687 (Clockwise)

Preceding gene: 59712946

Following gene: 59712951

Centisome position: 90.84

GC content: 38.3

Gene sequence:

>684_bases
ATGGCAAAGATTTTATTAGTTGATGATGATATTGAACTGACAGCTCTGTTAAAAGATATCTTAAGTTTAGAAGGCTATAA
CGTAATAGAAGCTAATAATGGTATTGAAGGTTTAGCTGCAATAACCGATGATCTTGACCTTATTTTGCTTGATATCATGA
TGCCTAAAATGAATGGCATGGATATGCTCCGTAAATTACGAGAGACAAATGAAACGCCTGTTCTTATGCTCACAGCCAAA
GGTGAAGAAATTGATCGTGTGATTGGTCTTGAGCTTGGTGCAGATGATTACTTACCAAAGCCATTTAGCGACAGAGAGTT
ACTAGCTCGAATTCGTGCCATCTTACGACGTACTCAAGGCAAAACAAAAGAGAGTAATAGCAGTAGTATCAAATACCAAG
ATATTGAACTCTTTGTTGGCAAACAAGAAGCTTATCGCAATGGTGAACTAATGGAGCTAACAGGAACTGAATTCGGTCTA
TTATCCCAGTTCATCCAAAAGCCAGGCGAAATAATATCGAAAGAAGATCTCAGCTTAGAAGTACTAGGCAAACGTCTTGC
ACCATTTGATCGTGCTATTGATATGCACGTGTCTAATTTACGCAAAAAATTACCGCCACTATCAGAAGGAAAACCTCGAA
TTAAAACATTACGAGGCCGCGGCTATTTGTTTGTAGAGGAGTAA

Upstream 100 bases:

>100_bases
CGTAAAGCAACGTAAAGGTTATTTTGAAGGTTGGTATTCCTTCGTTTATTTGGCGATACTATCATTACCAAATGGTTGGT
AAGAAAGCGAGTAGATAAGA

Downstream 100 bases:

>100_bases
TCGGTGTTTAAGGTAAATACTCGCTTCCCCCTTTTATCCAGCTTATATGGCCGGATCTTTGCCATTTTTTGGTTAACCTT
ACTATTGGTGCTTATTGGGG

Product: DNA-binding response regulator in two-component regulatory system with CpxA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MAKILLVDDDIELTALLKDILSLEGYNVIEANNGIEGLAAITDDLDLILLDIMMPKMNGMDMLRKLRETNETPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQGKTKESNSSSIKYQDIELFVGKQEAYRNGELMELTGTEFGL
LSQFIQKPGEIISKEDLSLEVLGKRLAPFDRAIDMHVSNLRKKLPPLSEGKPRIKTLRGRGYLFVEE

Sequences:

>Translated_227_residues
MAKILLVDDDIELTALLKDILSLEGYNVIEANNGIEGLAAITDDLDLILLDIMMPKMNGMDMLRKLRETNETPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQGKTKESNSSSIKYQDIELFVGKQEAYRNGELMELTGTEFGL
LSQFIQKPGEIISKEDLSLEVLGKRLAPFDRAIDMHVSNLRKKLPPLSEGKPRIKTLRGRGYLFVEE
>Mature_226_residues
AKILLVDDDIELTALLKDILSLEGYNVIEANNGIEGLAAITDDLDLILLDIMMPKMNGMDMLRKLRETNETPVLMLTAKG
EEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQGKTKESNSSSIKYQDIELFVGKQEAYRNGELMELTGTEFGLL
SQFIQKPGEIISKEDLSLEVLGKRLAPFDRAIDMHVSNLRKKLPPLSEGKPRIKTLRGRGYLFVEE

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=60.2620087336244, Blast_Score=260, Evalue=5e-71,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=40.6113537117904, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=37.4449339207048, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=35.3711790393013, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=37.1681415929204, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=39.5555555555556, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=37.3333333333333, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=36.1233480176211, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=34.841628959276, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=35.3448275862069, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=33.0396475770925, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=29.9107142857143, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.0851063829787, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=36.2903225806452, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790299, Length=125, Percent_Identity=31.2, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788905, Length=131, Percent_Identity=34.3511450381679, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25590; Mature: 25459

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILLVDDDIELTALLKDILSLEGYNVIEANNGIEGLAAITDDLDLILLDIMMPKMNGM
CEEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHCCCCCCH
DMLRKLRETNETPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQG
HHHHHHHHCCCCCEEEEEECCCHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
KTKESNSSSIKYQDIELFVGKQEAYRNGELMELTGTEFGLLSQFIQKPGEIISKEDLSLE
CCCCCCCCCEEEEEEEEEECCHHHHCCCCEEEECCCCHHHHHHHHHCCHHHCCCCCCHHH
VLGKRLAPFDRAIDMHVSNLRKKLPPLSEGKPRIKTLRGRGYLFVEE
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCEEEEEEC
>Mature Secondary Structure 
AKILLVDDDIELTALLKDILSLEGYNVIEANNGIEGLAAITDDLDLILLDIMMPKMNGM
EEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHCCCCCCH
DMLRKLRETNETPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQG
HHHHHHHHCCCCCEEEEEECCCHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
KTKESNSSSIKYQDIELFVGKQEAYRNGELMELTGTEFGLLSQFIQKPGEIISKEDLSLE
CCCCCCCCCEEEEEEEEEECCHHHHCCCCEEEECCCCHHHHHHHHHCCHHHCCCCCCHHH
VLGKRLAPFDRAIDMHVSNLRKKLPPLSEGKPRIKTLRGRGYLFVEE
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]