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The map label for this gene is cpxA [H]

Identifier: 59712951

GI number: 59712951

Start: 2632691

End: 2634079

Strand: Direct

Name: cpxA [H]

Synonym: VF_2344

Alternate gene names: 59712951

Gene position: 2632691-2634079 (Clockwise)

Preceding gene: 59712950

Following gene: 59712952

Centisome position: 90.86

GC content: 39.52

Gene sequence:

>1389_bases
GTGTTTAAGGTAAATACTCGCTTCCCCCTTTTATCCAGCTTATATGGCCGGATCTTTGCCATTTTTTGGTTAACCTTACT
ATTGGTGCTTATTGGGGTTGTTATTGGCCCCAACTTTGACCCCCGTTCTCGTCACAATATTGCAGCTGAGCATCTAACTA
AAATGACTCAAATTGCCGCTTACATTACAGGAAAGTACTCTGAGCGTGATAATTTGAAAAAAACATTGAAAGAGATCAGT
CACCGAGCGCATAGACACGACGAAAATCTTGATCTATTTTTCACCACCCCAACGGGTGAAATTTTAGATAAACCAAGAGA
ACTTCGAGGAAGAAAAAAAGCCTTACTTAACTTTTTAACGCTGTCTGATAATCCCGAATTACCACAACAAAAACTTTATG
GAAGAACCATGATGGCTGGTCCTTTTGATATCGTGATTGCCCATGAAACCGTTTATATGTATGTGGGGCGATATTGGAAA
AAGCCACCACCATTTATTCTTAGAATATTAGATAAACCAGGGCAATTACTCTTAGTTACCATGCTCGTTAGTACGCCCTT
TTTACTTTGGCTTGCTTGGGCATTAAGTCAACCTGCAAGGCGTTTACAAAAGGCAGCAGAGCGCGTTGCTAAAGGCCAAT
TTGAAAAAGATAAAGATCTTGAAAAAGGTCCAAGAGAGTTTAGAAAAACCGGACAAAGCTTTAATCAGATGGTTGGCTCA
TTAAATACTATGATTTCGGGTCAACAACGTTTACTTTCAGATATTTCACATGAATTACGCTCCCCGCTAACCCGTTTAAG
AATGGCAACTGCCCTTGCCACTCGTAAACAAGGGGAAAGTGCAGAATTATCTCGAATAGATATGGAAGCAGATCGTTTAG
AACAAATGATATCTGAGTTATTGGAGCTTTCTCGCATTCAAGTTAATAGTCATCAAGAGCGAGAAAAAACCGATGCTTAT
TCATTATGGTTTGATATTTTAGAAGACGCCAAATTTGAAGCCGAGCATTTAAATAAAGTACTGACTTACTCTGATTTAAA
AGAAACGCCTATTTTTGGGAACCCGAATTTATTAATGAGCGCAGTAGAAAACGTAATACGTAATGCCATTAAATACGGTA
ACGATGTAGTCACGGTGAACATTAATGACACAGGTAAAACTCTCACCATCATCGTTGATGATAATGGCGAAGGTGTCCCT
GAAGATGAACTACAAGATATCTTTAAACCTTTCTACCGTGTCTCTACCGCTCGTGATCGAAGCAGTGGCGGAACTGGGCT
TGGTTTAGCGATTACTGAAAGTGCCATTTATCAACACAATGGGACAATTATTGCGAGCCGAAGTCCATTAGGTGGATTAC
GAATGACAATAACACTGCCAATAGAATAA

Upstream 100 bases:

>100_bases
CGTGTCTAATTTACGCAAAAAATTACCGCCACTATCAGAAGGAAAACCTCGAATTAAAACATTACGAGGCCGCGGCTATT
TGTTTGTAGAGGAGTAATCG

Downstream 100 bases:

>100_bases
ATTCTTCAAAACCTAACACTCGTGGCTTATATCAAACAAAACGAATCTCGATATAAGTCATGTGTTATTTGGATGAGTTT
AGATATACTGCTTTTAATTT

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MFKVNTRFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRSRHNIAAEHLTKMTQIAAYITGKYSERDNLKKTLKEIS
HRAHRHDENLDLFFTTPTGEILDKPRELRGRKKALLNFLTLSDNPELPQQKLYGRTMMAGPFDIVIAHETVYMYVGRYWK
KPPPFILRILDKPGQLLLVTMLVSTPFLLWLAWALSQPARRLQKAAERVAKGQFEKDKDLEKGPREFRKTGQSFNQMVGS
LNTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESAELSRIDMEADRLEQMISELLELSRIQVNSHQEREKTDAY
SLWFDILEDAKFEAEHLNKVLTYSDLKETPIFGNPNLLMSAVENVIRNAIKYGNDVVTVNINDTGKTLTIIVDDNGEGVP
EDELQDIFKPFYRVSTARDRSSGGTGLGLAITESAIYQHNGTIIASRSPLGGLRMTITLPIE

Sequences:

>Translated_462_residues
MFKVNTRFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRSRHNIAAEHLTKMTQIAAYITGKYSERDNLKKTLKEIS
HRAHRHDENLDLFFTTPTGEILDKPRELRGRKKALLNFLTLSDNPELPQQKLYGRTMMAGPFDIVIAHETVYMYVGRYWK
KPPPFILRILDKPGQLLLVTMLVSTPFLLWLAWALSQPARRLQKAAERVAKGQFEKDKDLEKGPREFRKTGQSFNQMVGS
LNTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESAELSRIDMEADRLEQMISELLELSRIQVNSHQEREKTDAY
SLWFDILEDAKFEAEHLNKVLTYSDLKETPIFGNPNLLMSAVENVIRNAIKYGNDVVTVNINDTGKTLTIIVDDNGEGVP
EDELQDIFKPFYRVSTARDRSSGGTGLGLAITESAIYQHNGTIIASRSPLGGLRMTITLPIE
>Mature_462_residues
MFKVNTRFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRSRHNIAAEHLTKMTQIAAYITGKYSERDNLKKTLKEIS
HRAHRHDENLDLFFTTPTGEILDKPRELRGRKKALLNFLTLSDNPELPQQKLYGRTMMAGPFDIVIAHETVYMYVGRYWK
KPPPFILRILDKPGQLLLVTMLVSTPFLLWLAWALSQPARRLQKAAERVAKGQFEKDKDLEKGPREFRKTGQSFNQMVGS
LNTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESAELSRIDMEADRLEQMISELLELSRIQVNSHQEREKTDAY
SLWFDILEDAKFEAEHLNKVLTYSDLKETPIFGNPNLLMSAVENVIRNAIKYGNDVVTVNINDTGKTLTIIVDDNGEGVP
EDELQDIFKPFYRVSTARDRSSGGTGLGLAITESAIYQHNGTIIASRSPLGGLRMTITLPIE

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=459, Percent_Identity=43.5729847494553, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1787894, Length=308, Percent_Identity=29.5454545454545, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=30.5755395683453, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=26.8852459016393, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=27.4436090225564, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082128, Length=276, Percent_Identity=28.2608695652174, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=26.5217391304348, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=30.2752293577982, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=27.3469387755102, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=27, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789403, Length=321, Percent_Identity=28.3489096573209, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=29.2792792792793, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=24.4147157190635, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=27.3542600896861, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=23.8297872340426, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=26.457399103139, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=22.680412371134, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52469; Mature: 52469

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKVNTRFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRSRHNIAAEHLTKMTQIAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
YITGKYSERDNLKKTLKEISHRAHRHDENLDLFFTTPTGEILDKPRELRGRKKALLNFLT
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHC
LSDNPELPQQKLYGRTMMAGPFDIVIAHETVYMYVGRYWKKPPPFILRILDKPGQLLLVT
CCCCCCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHEECCCCHHHHHH
MLVSTPFLLWLAWALSQPARRLQKAAERVAKGQFEKDKDLEKGPREFRKTGQSFNQMVGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHH
LNTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESAELSRIDMEADRLEQMISEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHH
LELSRIQVNSHQEREKTDAYSLWFDILEDAKFEAEHLNKVLTYSDLKETPIFGNPNLLMS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
AVENVIRNAIKYGNDVVTVNINDTGKTLTIIVDDNGEGVPEDELQDIFKPFYRVSTARDR
HHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
SSGGTGLGLAITESAIYQHNGTIIASRSPLGGLRMTITLPIE
CCCCCCEEHEEEHHHHEECCCEEEEECCCCCCEEEEEEEECC
>Mature Secondary Structure
MFKVNTRFPLLSSLYGRIFAIFWLTLLLVLIGVVIGPNFDPRSRHNIAAEHLTKMTQIAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
YITGKYSERDNLKKTLKEISHRAHRHDENLDLFFTTPTGEILDKPRELRGRKKALLNFLT
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHC
LSDNPELPQQKLYGRTMMAGPFDIVIAHETVYMYVGRYWKKPPPFILRILDKPGQLLLVT
CCCCCCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHEECCCCHHHHHH
MLVSTPFLLWLAWALSQPARRLQKAAERVAKGQFEKDKDLEKGPREFRKTGQSFNQMVGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHH
LNTMISGQQRLLSDISHELRSPLTRLRMATALATRKQGESAELSRIDMEADRLEQMISEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHH
LELSRIQVNSHQEREKTDAYSLWFDILEDAKFEAEHLNKVLTYSDLKETPIFGNPNLLMS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
AVENVIRNAIKYGNDVVTVNINDTGKTLTIIVDDNGEGVPEDELQDIFKPFYRVSTARDR
HHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
SSGGTGLGLAITESAIYQHNGTIIASRSPLGGLRMTITLPIE
CCCCCCEEHEEEHHHHEECCCEEEEECCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]