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The map label for this gene is frdD [H]

Identifier: 59712944

GI number: 59712944

Start: 2626669

End: 2627091

Strand: Direct

Name: frdD [H]

Synonym: VF_2337

Alternate gene names: 59712944

Gene position: 2626669-2627091 (Clockwise)

Preceding gene: 59712943

Following gene: 59712946

Centisome position: 90.65

GC content: 43.03

Gene sequence:

>423_bases
ATGGGCAGCAGTTGCTGCTATCACATTACTTGTACTGGTTATCGTTTAAGGAGAATTATTGTGGTAAATCGTAATCCAAA
GCGTTCTGACGAACCAGTATGGTGGGGCTTATTTGGTGCTGGCGGCACTTGGTTTGCAATGCTAACACCTGTAACTATCT
TAGTTCTTGGTATCTTAGTTCCACTAGGTGTGATCGGTCCTGAATCAATGAACTACCTACGTGTTGCTGGTTTTGTTACT
AGCATCATTGGTGCATTATTTGTTATCGGCTCTATCTCTATGCCAATGTGGCATGCGATGCACCGTTTGCACCATGGTAT
GCATGACCTAAAATTCCACACAGGTACTGCGGGTAAAATCGCATGTTATGCAGCAGCGGCACTAGCAACTGTATTATCTG
TTGTGTTTATCTTCATGATCTAA

Upstream 100 bases:

>100_bases
GCTTATTCCATGCTCAAACCTTCTTTAGCATGATGCCGCAAGTAATGCCGATTCGTCTTGGTGGTAAAACACTAGATAAG
AAAGTGGTTGTTCTTGCACA

Downstream 100 bases:

>100_bases
TCATCATCTAGATACGAAAAAAAGGTTGGCTTTATGCCAACCTTTTTTGTATCTGCTATGTAATAAAAAAGGCCACCGAA
GTGACCTTTTATACCATTCT

Product: fumarate reductase subunit D

Products: fumarate; reduced acceptor; succinate; menaquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MGSSCCYHITCTGYRLRRIIVVNRNPKRSDEPVWWGLFGAGGTWFAMLTPVTILVLGILVPLGVIGPESMNYLRVAGFVT
SIIGALFVIGSISMPMWHAMHRLHHGMHDLKFHTGTAGKIACYAAAALATVLSVVFIFMI

Sequences:

>Translated_140_residues
MGSSCCYHITCTGYRLRRIIVVNRNPKRSDEPVWWGLFGAGGTWFAMLTPVTILVLGILVPLGVIGPESMNYLRVAGFVT
SIIGALFVIGSISMPMWHAMHRLHHGMHDLKFHTGTAGKIACYAAAALATVLSVVFIFMI
>Mature_139_residues
GSSCCYHITCTGYRLRRIIVVNRNPKRSDEPVWWGLFGAGGTWFAMLTPVTILVLGILVPLGVIGPESMNYLRVAGFVTS
IIGALFVIGSISMPMWHAMHRLHHGMHDLKFHTGTAGKIACYAAAALATVLSVVFIFMI

Specific function: Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane [H]

COG id: COG3080

COG function: function code C; Fumarate reductase subunit D

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the frdD family [H]

Homologues:

Organism=Escherichia coli, GI1790594, Length=115, Percent_Identity=51.304347826087, Blast_Score=124, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003418
- ProDom:   PD015693 [H]

Pfam domain/function: PF02313 Fumarate_red_D [H]

EC number: NA

Molecular weight: Translated: 15306; Mature: 15174

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSCCYHITCTGYRLRRIIVVNRNPKRSDEPVWWGLFGAGGTWFAMLTPVTILVLGILV
CCCCEEEEEEECCEEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
PLGVIGPESMNYLRVAGFVTSIIGALFVIGSISMPMWHAMHRLHHGMHDLKFHTGTAGKI
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCEEECCCCCHH
ACYAAAALATVLSVVFIFMI
HHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
GSSCCYHITCTGYRLRRIIVVNRNPKRSDEPVWWGLFGAGGTWFAMLTPVTILVLGILV
CCCEEEEEEECCEEEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
PLGVIGPESMNYLRVAGFVTSIIGALFVIGSISMPMWHAMHRLHHGMHDLKFHTGTAGKI
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCEEECCCCCHH
ACYAAAALATVLSVVFIFMI
HHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: succinate; acceptor; fumarate; reduced menaquinone [C]

Specific reaction: succinate + acceptor = fumarate + reduced acceptor fumarate + reduced menaquinone = succinate + menaquinone [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA