Click here to switch to the map view.

The map label for this gene is lpxC [H]

Identifier: 59712802

GI number: 59712802

Start: 2466619

End: 2467536

Strand: Reverse

Name: lpxC [H]

Synonym: VF_2195

Alternate gene names: 59712802

Gene position: 2467536-2466619 (Counterclockwise)

Preceding gene: 59712803

Following gene: 59712800

Centisome position: 85.16

GC content: 41.29

Gene sequence:

>918_bases
ATGATCAGACAACGTACACTGAAAAGTATCGTACAAATGACAGGCGTGGGTTTACACTCAGGCCGTAAAGTTACGCTTAC
TCTTCGTCCAGCAGCTGCGAACACAGGTGTGATTTATCGTCGTACAGACCTTAATCCGCCAGTTGATTTCCCTGCGGATC
CAGAGTCAGTTCGTGACACGATGCTATGTACAGCGTTAGTTAATGATGAAGGCGTACGTATCTCAACGGTTGAGCACTTG
AATGCTGCTTTAGCAGGCATGGGCATTGATAACGTTGTTATCGAGGTTGATGCTCCTGAAATTCCAATTATGGATGGCAG
TGCAAGTCCTTTTGTATATCTTTTACAATCTGCAGGTATTGAAGAACTTAATACAGCGAAGAAATTCATTCGTATTAAGA
AACCTGTTCGCATAGAAGATGGTGATAAGTGGGCTGAAATTCGTCCTTACAACGGTTTCCGTTTAGATTTCACTATTGAC
TTTAATCACCCTGCGATTGAATCAGATGACCAAAAGTTAGTGTTTGATTTTTCAAGCCAATCGTTTATCAAAGATATTTC
ACGAGCTCGTACTTTTGGGTTTATGCGTGATATCGAGTACTTACAATCGCAAAACCTATGTTTAGGTGGTAGCTTTGATT
GTGCAATCGTACTTGATGATTACCGAATCCTAAATGAAGACGGTTTACGCTTTGATAATGAATTTGTAACGCATAAAGTT
CTAGATGCTGTTGGTGACCTATATATGTCAGGTCATAGTATTCTAGGTGAACTTCGTGCATACAAATCAGGTCACGCTTT
GAATAATCAGCTACTTCGTGCAGTTCTTGCAGATCAAGAAGCATGGGAGTGGACGACCATTGAGGATGAGCAAGAGTCTC
CAGTTGCATTTATGCAACCAGGAATGGTACTTGCGTAA

Upstream 100 bases:

>100_bases
CATCAAACGATTTGGTTTTATGAAAAATTGTGTGCTAGAATGTCAGACCAGTTCTTAGAATTGGTTTGAAATTAAGCATA
TTTATAGTTGAGATGAGCAT

Downstream 100 bases:

>100_bases
GTAACACATCATCAAATTAAAAAAGCCAAGCGAATGCTTGGCTTTTTTGTATCTAATATTTTCTTAGTTCTACTTCTTAC
TTTCTATTTGCTAATGCAGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDTMLCTALVNDEGVRISTVEHL
NAALAGMGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGIEELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTID
FNHPAIESDDQKLVFDFSSQSFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFDNEFVTHKV
LDAVGDLYMSGHSILGELRAYKSGHALNNQLLRAVLADQEAWEWTTIEDEQESPVAFMQPGMVLA

Sequences:

>Translated_305_residues
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDTMLCTALVNDEGVRISTVEHL
NAALAGMGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGIEELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTID
FNHPAIESDDQKLVFDFSSQSFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFDNEFVTHKV
LDAVGDLYMSGHSILGELRAYKSGHALNNQLLRAVLADQEAWEWTTIEDEQESPVAFMQPGMVLA
>Mature_305_residues
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDTMLCTALVNDEGVRISTVEHL
NAALAGMGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGIEELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTID
FNHPAIESDDQKLVFDFSSQSFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFDNEFVTHKV
LDAVGDLYMSGHSILGELRAYKSGHALNNQLLRAVLADQEAWEWTTIEDEQESPVAFMQPGMVLA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=76.3934426229508, Blast_Score=504, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 34101; Mature: 34101

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDT
CCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTALVNDEGVRISTVEHLNAALAGMGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGI
EEEEEEECCCCCEEEHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCHHHEEHHCCH
EELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTIDFNHPAIESDDQKLVFDFSSQ
HHHHHHHHHHHHCCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEECCCH
SFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFDNEFVTHKV
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECEEEECCCCCEECHHHHHHHH
LDAVGDLYMSGHSILGELRAYKSGHALNNQLLRAVLADQEAWEWTTIEDEQESPVAFMQP
HHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECC
GMVLA
CEECC
>Mature Secondary Structure
MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDT
CCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHH
MLCTALVNDEGVRISTVEHLNAALAGMGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGI
EEEEEEECCCCCEEEHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCHHHEEHHCCH
EELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTIDFNHPAIESDDQKLVFDFSSQ
HHHHHHHHHHHHCCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEECCCH
SFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFDNEFVTHKV
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECEEEECCCCCEECHHHHHHHH
LDAVGDLYMSGHSILGELRAYKSGHALNNQLLRAVLADQEAWEWTTIEDEQESPVAFMQP
HHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECC
GMVLA
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA