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The map label for this gene is coaE

Identifier: 59712796

GI number: 59712796

Start: 2460862

End: 2461410

Strand: Direct

Name: coaE

Synonym: VF_2189

Alternate gene names: 59712796

Gene position: 2460862-2461410 (Clockwise)

Preceding gene: 59712795

Following gene: 59712797

Centisome position: 84.93

GC content: 36.43

Gene sequence:

>549_bases
ATGAGTTATGTCGTAGCAATTACTGGTGGTATTGGTAGTGGAAAAACTACCGTTGCCGATCGCTTTCAAGCACTCTATAA
CATCAATATTGTTGATGCTGATATTATTGCTCGTGAAGTTGTTAATCCAGGAACCGAAGGATTAATCCAAATAGAGCAAC
ATTTTGGACCACAAATCTTACTGGACGATGGCCATTTAAATAGAGCGAAGTTGCGTGAGTGTATTTTTTCTGAACCTAGT
GAAAAACAGTGGCTCAATGATTTATTACATCCATTGATCCGTTCAGAGATGCAACGTCAAATAGCTTTATCCACTTCAGA
GTACACATTGCTTGTAGTGCCTCTTTTAGTTGAGAATAAGTTACAATATTTAGCAAATCGTGTACTTGTTGTTGATGTTT
TGGAGCAAACTCAAATTAATCGCACTGTAAATCGTGATAAAGTAAATCATCAACAAGTTAAAGCAATTCTTGCTTCACAA
GCATCAAGAGAAGAACGTTTAGCGGCTGCGGATGATATAATTAATAACGATCACAAAATAATGACTTAG

Upstream 100 bases:

>100_bases
TTCCCTTTGGTCCTTATTTAGCTATTGCTGGCTGGGTTTGCCTATTATGGGGACAAAACATTAGCCAATGGTATTTTAAT
CACATTCTAGGTTTGCCACT

Downstream 100 bases:

>100_bases
ATATGAAAATATCTCTGCTACATGAGAAATATCTGCTATTGTCTCTGGCATCTATAAATAAAGAGAATGAATAACGACTA
TGAATGGATTGGGTATGCAA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MSYVVAITGGIGSGKTTVADRFQALYNINIVDADIIAREVVNPGTEGLIQIEQHFGPQILLDDGHLNRAKLRECIFSEPS
EKQWLNDLLHPLIRSEMQRQIALSTSEYTLLVVPLLVENKLQYLANRVLVVDVLEQTQINRTVNRDKVNHQQVKAILASQ
ASREERLAAADDIINNDHKIMT

Sequences:

>Translated_182_residues
MSYVVAITGGIGSGKTTVADRFQALYNINIVDADIIAREVVNPGTEGLIQIEQHFGPQILLDDGHLNRAKLRECIFSEPS
EKQWLNDLLHPLIRSEMQRQIALSTSEYTLLVVPLLVENKLQYLANRVLVVDVLEQTQINRTVNRDKVNHQQVKAILASQ
ASREERLAAADDIINNDHKIMT
>Mature_181_residues
SYVVAITGGIGSGKTTVADRFQALYNINIVDADIIAREVVNPGTEGLIQIEQHFGPQILLDDGHLNRAKLRECIFSEPSE
KQWLNDLLHPLIRSEMQRQIALSTSEYTLLVVPLLVENKLQYLANRVLVVDVLEQTQINRTVNRDKVNHQQVKAILASQA
SREERLAAADDIINNDHKIMT

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=179, Percent_Identity=35.195530726257, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI191252795, Length=179, Percent_Identity=35.195530726257, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI110227607, Length=167, Percent_Identity=28.7425149700599, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI110227605, Length=167, Percent_Identity=28.7425149700599, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI110227603, Length=167, Percent_Identity=28.7425149700599, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI110227601, Length=167, Percent_Identity=28.7425149700599, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI205277394, Length=167, Percent_Identity=28.7425149700599, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1786292, Length=177, Percent_Identity=59.3220338983051, Blast_Score=196, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17554944, Length=182, Percent_Identity=32.967032967033, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25143409, Length=165, Percent_Identity=26.0606060606061, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320402, Length=185, Percent_Identity=38.9189189189189, Blast_Score=119, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24644728, Length=182, Percent_Identity=29.1208791208791, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24658602, Length=185, Percent_Identity=28.6486486486486, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_VIBF1 (Q5E2R2)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205572.1
- ProteinModelPortal:   Q5E2R2
- SMR:   Q5E2R2
- STRING:   Q5E2R2
- GeneID:   3279516
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2189
- NMPDR:   fig|312309.3.peg.2189
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   Q5E2R2
- ProtClustDB:   PRK00081
- BioCyc:   VFIS312309:VF2189-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 20464; Mature: 20333

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYVVAITGGIGSGKTTVADRFQALYNINIVDADIIAREVVNPGTEGLIQIEQHFGPQIL
CCEEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHCCCCCCCEEEEHHCCCCEEE
LDDGHLNRAKLRECIFSEPSEKQWLNDLLHPLIRSEMQRQIALSTSEYTLLVVPLLVENK
EECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
LQYLANRVLVVDVLEQTQINRTVNRDKVNHQQVKAILASQASREERLAAADDIINNDHKI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
MT
CC
>Mature Secondary Structure 
SYVVAITGGIGSGKTTVADRFQALYNINIVDADIIAREVVNPGTEGLIQIEQHFGPQIL
CEEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHCCCCCCCEEEEHHCCCCEEE
LDDGHLNRAKLRECIFSEPSEKQWLNDLLHPLIRSEMQRQIALSTSEYTLLVVPLLVENK
EECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
LQYLANRVLVVDVLEQTQINRTVNRDKVNHQQVKAILASQASREERLAAADDIINNDHKI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
MT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA