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The map label for this gene is pilC [H]

Identifier: 59712794

GI number: 59712794

Start: 2458635

End: 2459873

Strand: Direct

Name: pilC [H]

Synonym: VF_2187

Alternate gene names: 59712794

Gene position: 2458635-2459873 (Clockwise)

Preceding gene: 59712793

Following gene: 59712795

Centisome position: 84.85

GC content: 37.61

Gene sequence:

>1239_bases
ATGCCTAAAACAAAAAAGAAATCCAAAGCAGTCGTATTAAAAAGCTTTCAATGGCGTGGCATTAACAGTTCAGGGAAAAA
AGTATCTGGAAAACAGCTCGCGTTAAGTGATGCTGAAGTCAGAACAAAATTAACTGAACAAAATATCCAGATTAAAAAAA
TTAAAAAGCGTAGTATTTCTAGCTTTGAAAAAATGAAGCACGCGGTTAAGCGAAAAGACATCACCCTCTTTACTCGCCAG
CTTTCTACCATGCTCGCCTCAGGTGTTCCAGTTGTTCAGTCACTGCACCTCATCGCAGAAAACAACACTAAAGCGGAAAT
GAAATCCATTTTGCATCAAGTTTGCTTATCCATCGAAGCAGGTACTCAATTATCTAAAGCGCTCTCTACCAGTTGTTCTC
ATTTTGATTCTTTTTATATCGACCTTATAGCGACTGGTGAAGAGACAGGCAGCTTAGCTCAGGCATTCGCTCGCTTGGCA
GAGTATAGGGAAAAAAGTGATGCTTTGCGTTCCAAAGTAATCAAAGCCATGATTTATCCAACCATGGTTTTTTTAGTTGC
GATAACCGTAACTATTTTAATGCTTACTTTTGTTATCCCAGAATTTGAGAATATTTTTAAAGGCTTTGGCGCTGAATTAC
CTTGGTTTACTCAACAGGTAATTAATATCTCTCATAACTTACAAGAGTATGGTCTATATATTCTTTTACTTATTATGCTC
ACTATCCTAATGCTCAGTGCATTAAAGAAGAAATCTTACTTTTTTAGAATGAAAGTGAGTCGTCATAGCTTACAAATTCC
CATCATTGGTACCGTGCTGTCTAAAGCTGCCATTGCCAAATTTTCCCGTACCTTAGCAACCAGTTTTAGCTCAGGTTTGC
CGATTTTACACAGCTTACAAACCACCAGTAAAACCGCCGGTAATCTTTACTATCAAGAAGCCATCTTATCTGTACAACAG
CACACCGCTGCAGGTATGCCCCTTTATATTGCTATGCGACATACCGAAGTTTTTCCTGAAATGGTATTGCAAATGGTCAT
GATTGGAGAAGAATCAGGAAAGCTAGATGACATGCTAAATAAAATTGCTCATGTTTATGAGGAAGATGTTGATAATACCG
TAGATAACTTAGGTAAAATTCTAGAGCCTTTTATTATCGTTTTTCTTGGTACCATGATTGGTGGTTTAGTGGTGTCTATG
TATCTTCCAATCTTTAACCTTATGAGTGTTATTGGCTAA

Upstream 100 bases:

>100_bases
AACCTAAAAACCTCAGGAATTAAACGATTAGAAGATGGCACCACCAGCTTACAAGAACTAAACCGTGTGCTCTATTTTTA
AAGATAAGTAGATAATTCAA

Downstream 100 bases:

>100_bases
AACGTGTAATAAGTGCGTTAAGTTTATACTCTTAACTACTTCATTTTAATGAATTCTGATACCATCAGCTAAATACGTTA
ATTACTGATATTGGACGCTT

Product: pilus assembly protein PilC

Products: NA

Alternate protein names: Type IV-A pilus assembly protein pilC [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MPKTKKKSKAVVLKSFQWRGINSSGKKVSGKQLALSDAEVRTKLTEQNIQIKKIKKRSISSFEKMKHAVKRKDITLFTRQ
LSTMLASGVPVVQSLHLIAENNTKAEMKSILHQVCLSIEAGTQLSKALSTSCSHFDSFYIDLIATGEETGSLAQAFARLA
EYREKSDALRSKVIKAMIYPTMVFLVAITVTILMLTFVIPEFENIFKGFGAELPWFTQQVINISHNLQEYGLYILLLIML
TILMLSALKKKSYFFRMKVSRHSLQIPIIGTVLSKAAIAKFSRTLATSFSSGLPILHSLQTTSKTAGNLYYQEAILSVQQ
HTAAGMPLYIAMRHTEVFPEMVLQMVMIGEESGKLDDMLNKIAHVYEEDVDNTVDNLGKILEPFIIVFLGTMIGGLVVSM
YLPIFNLMSVIG

Sequences:

>Translated_412_residues
MPKTKKKSKAVVLKSFQWRGINSSGKKVSGKQLALSDAEVRTKLTEQNIQIKKIKKRSISSFEKMKHAVKRKDITLFTRQ
LSTMLASGVPVVQSLHLIAENNTKAEMKSILHQVCLSIEAGTQLSKALSTSCSHFDSFYIDLIATGEETGSLAQAFARLA
EYREKSDALRSKVIKAMIYPTMVFLVAITVTILMLTFVIPEFENIFKGFGAELPWFTQQVINISHNLQEYGLYILLLIML
TILMLSALKKKSYFFRMKVSRHSLQIPIIGTVLSKAAIAKFSRTLATSFSSGLPILHSLQTTSKTAGNLYYQEAILSVQQ
HTAAGMPLYIAMRHTEVFPEMVLQMVMIGEESGKLDDMLNKIAHVYEEDVDNTVDNLGKILEPFIIVFLGTMIGGLVVSM
YLPIFNLMSVIG
>Mature_411_residues
PKTKKKSKAVVLKSFQWRGINSSGKKVSGKQLALSDAEVRTKLTEQNIQIKKIKKRSISSFEKMKHAVKRKDITLFTRQL
STMLASGVPVVQSLHLIAENNTKAEMKSILHQVCLSIEAGTQLSKALSTSCSHFDSFYIDLIATGEETGSLAQAFARLAE
YREKSDALRSKVIKAMIYPTMVFLVAITVTILMLTFVIPEFENIFKGFGAELPWFTQQVINISHNLQEYGLYILLLIMLT
ILMLSALKKKSYFFRMKVSRHSLQIPIIGTVLSKAAIAKFSRTLATSFSSGLPILHSLQTTSKTAGNLYYQEAILSVQQH
TAAGMPLYIAMRHTEVFPEMVLQMVMIGEESGKLDDMLNKIAHVYEEDVDNTVDNLGKILEPFIIVFLGTMIGGLVVSMY
LPIFNLMSVIG

Specific function: Involved in the translocation of the type IV pilin [H]

COG id: COG1459

COG function: function code NU; Type II secretory pathway, component PulF

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP F family [H]

Homologues:

Organism=Escherichia coli, GI1789724, Length=402, Percent_Identity=29.1044776119403, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1786295, Length=393, Percent_Identity=30.2798982188295, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003004
- InterPro:   IPR018076
- InterPro:   IPR001992 [H]

Pfam domain/function: PF00482 GSPII_F [H]

EC number: NA

Molecular weight: Translated: 45988; Mature: 45857

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS00874 T2SP_F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTKKKSKAVVLKSFQWRGINSSGKKVSGKQLALSDAEVRTKLTEQNIQIKKIKKRSIS
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCCHHHHHHHHHHH
SFEKMKHAVKRKDITLFTRQLSTMLASGVPVVQSLHLIAENNTKAEMKSILHQVCLSIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GTQLSKALSTSCSHFDSFYIDLIATGEETGSLAQAFARLAEYREKSDALRSKVIKAMIYP
CHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMVFLVAITVTILMLTFVIPEFENIFKGFGAELPWFTQQVINISHNLQEYGLYILLLIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TILMLSALKKKSYFFRMKVSRHSLQIPIIGTVLSKAAIAKFSRTLATSFSSGLPILHSLQ
HHHHHHHHHHHHHHEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
TTSKTAGNLYYQEAILSVQQHTAAGMPLYIAMRHTEVFPEMVLQMVMIGEESGKLDDMLN
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHH
KIAHVYEEDVDNTVDNLGKILEPFIIVFLGTMIGGLVVSMYLPIFNLMSVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
PKTKKKSKAVVLKSFQWRGINSSGKKVSGKQLALSDAEVRTKLTEQNIQIKKIKKRSIS
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCCHHHHHHHHHHH
SFEKMKHAVKRKDITLFTRQLSTMLASGVPVVQSLHLIAENNTKAEMKSILHQVCLSIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GTQLSKALSTSCSHFDSFYIDLIATGEETGSLAQAFARLAEYREKSDALRSKVIKAMIYP
CHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMVFLVAITVTILMLTFVIPEFENIFKGFGAELPWFTQQVINISHNLQEYGLYILLLIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TILMLSALKKKSYFFRMKVSRHSLQIPIIGTVLSKAAIAKFSRTLATSFSSGLPILHSLQ
HHHHHHHHHHHHHHEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
TTSKTAGNLYYQEAILSVQQHTAAGMPLYIAMRHTEVFPEMVLQMVMIGEESGKLDDMLN
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHH
KIAHVYEEDVDNTVDNLGKILEPFIIVFLGTMIGGLVVSMYLPIFNLMSVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10024587; 10952301 [H]