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The map label for this gene is rnc

Identifier: 59712694

GI number: 59712694

Start: 2324375

End: 2325046

Strand: Reverse

Name: rnc

Synonym: VF_2087

Alternate gene names: 59712694

Gene position: 2325046-2324375 (Counterclockwise)

Preceding gene: 59712695

Following gene: 59712693

Centisome position: 80.24

GC content: 41.52

Gene sequence:

>672_bases
ATGAATTCTTCACTACAACGCTTAGAAAAGAAAATTGGCTATCAATTTAAAGATGAAAGTTTTCTTAAGTTAGCACTGAC
TCACCGTAGCGCTAATGGTACACACAATGAACGTCTAGAGTTTTTAGGCGACTCGATTTTGAGCTTTGTTGTTGCAGATG
ATTTGTACCACCGTTTCCCTAAAGTGGATGAAGGTGATATGAGTCGTATGCGTGCAACATTAGTTCGTGGTCATACATTA
GCAGAGCTTGGTCGTGAGTTTCAGCTAGGTGATTACCTATACTTAGGCCCTGGCGAATTAAAAAGTGGTGGTTTCCGTCG
TGATTCTATTTTAGCGGATGCGGTAGAAGCAATTATCGGTGCTATCTATTTAGATAGTGATACTGAAACAGTACGTGGCA
TTATTTTATCTTGGTACAACACTCGCCTTGAATCAATTGAACCTGGCGTATCTCAGAAAGACCCGAAAACACGTCTTCAA
GAGTACTTACAAGGTCGTCGTAAGCCATTACCTACGTACACAGTAACGAAAATTAAAGGTGAAGCTCATAATCAAGAGTT
CACTATTGAATGTATCGTGGCTGGCTTGGATAAGCCGGTTATCGGAAAAGGAAGCAGTCGCCGCAAGGCAGAACAGTCGG
CTGCTGACATTGCATTAGGACAACTTAACTAA

Upstream 100 bases:

>100_bases
AGCTTTGAATTTGACCGTGGTAGCGATAGCATGCTGCCTTCCTTTATTCCTACTGGTGTTCGTTTCAATCGCATCGGTGG
CATAGACTGATTAAAAATAT

Downstream 100 bases:

>100_bases
TGTCAGATGAAAAAGAATTTGATTTAGACGCGTATTTCGCATCAGAAAAAAAATCAGAAGTAAGTGATAACCAACACTGT
GGTTTCATTGCGATTGTTGG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNSSLQRLEKKIGYQFKDESFLKLALTHRSANGTHNERLEFLGDSILSFVVADDLYHRFPKVDEGDMSRMRATLVRGHTL
AELGREFQLGDYLYLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDTETVRGIILSWYNTRLESIEPGVSQKDPKTRLQ
EYLQGRRKPLPTYTVTKIKGEAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQLN

Sequences:

>Translated_223_residues
MNSSLQRLEKKIGYQFKDESFLKLALTHRSANGTHNERLEFLGDSILSFVVADDLYHRFPKVDEGDMSRMRATLVRGHTL
AELGREFQLGDYLYLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDTETVRGIILSWYNTRLESIEPGVSQKDPKTRLQ
EYLQGRRKPLPTYTVTKIKGEAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQLN
>Mature_223_residues
MNSSLQRLEKKIGYQFKDESFLKLALTHRSANGTHNERLEFLGDSILSFVVADDLYHRFPKVDEGDMSRMRATLVRGHTL
AELGREFQLGDYLYLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDTETVRGIILSWYNTRLESIEPGVSQKDPKTRLQ
EYLQGRRKPLPTYTVTKIKGEAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQLN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=30.5676855895196, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=30.5676855895196, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788920, Length=218, Percent_Identity=70.1834862385321, Blast_Score=314, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=32.4675324675325, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=32.4675324675325, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=29.8245614035088, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_VIBF1 (Q5E314)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205470.1
- ProteinModelPortal:   Q5E314
- SMR:   Q5E314
- STRING:   Q5E314
- GeneID:   3279279
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2087
- NMPDR:   fig|312309.3.peg.2087
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q5E314
- ProtClustDB:   PRK00102
- BioCyc:   VFIS312309:VF2087-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 24975; Mature: 24975

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSLQRLEKKIGYQFKDESFLKLALTHRSANGTHNERLEFLGDSILSFVVADDLYHRFP
CCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KVDEGDMSRMRATLVRGHTLAELGREFQLGDYLYLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
AIYLDSDTETVRGIILSWYNTRLESIEPGVSQKDPKTRLQEYLQGRRKPLPTYTVTKIKG
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEC
EAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQLN
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSSLQRLEKKIGYQFKDESFLKLALTHRSANGTHNERLEFLGDSILSFVVADDLYHRFP
CCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KVDEGDMSRMRATLVRGHTLAELGREFQLGDYLYLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
AIYLDSDTETVRGIILSWYNTRLESIEPGVSQKDPKTRLQEYLQGRRKPLPTYTVTKIKG
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEC
EAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQLN
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA