Click here to switch to the map view.

The map label for this gene is era [H]

Identifier: 59712693

GI number: 59712693

Start: 2323410

End: 2324375

Strand: Reverse

Name: era [H]

Synonym: VF_2086

Alternate gene names: 59712693

Gene position: 2324375-2323410 (Counterclockwise)

Preceding gene: 59712694

Following gene: 59712692

Centisome position: 80.22

GC content: 38.2

Gene sequence:

>966_bases
ATGTCAGATGAAAAAGAATTTGATTTAGACGCGTATTTCGCATCAGAAAAAAAATCAGAAGTAAGTGATAACCAACACTG
TGGTTTCATTGCGATTGTTGGTCGTCCAAATGTGGGTAAATCAACACTTCTTAACCAAATCTTAGGTCAGAAGATTTCGA
TTACGTCACGTAAGCCACAGACTACTCGTCACCGTATTATGGGTGTTGATACTGATGGTGATTATCAAGCGATTTATGTT
GATACTCCGGGGCTTCATATTGAAGAAAAACGTGCTATTAACCGTTTGATGAACCGTGCAGCAAACTCATCGTTAAGTGA
TGTGAACCTAGTATTATTCCTTGTGGATGGTACTCACTGGACTCCTGATGATGAAATGGTTCTAAACAAGCTGAAGAAAT
CTGAATTCCCAACAGTATTGTTAGTGAATAAAGTTGATAACGTTAAAGATAAAAAAGACGTTATGACTCACTTACAAGAG
ATGACTGAAAAAATGGATTTTGTTGATGTTGTGCCAATTTCAGCAAAAACAGGTTCGAACGTAGATGTAGTTCATAAGTT
AGTTCGTGAATACTTACCTAAAGCGGTTCACCACTTCCCTGAAGAATACGTAACTGACCGTTCTCAACGTTTCATGGCAT
CAGAAATTATCCGTGAAAAACTGATGCGTTTTACTGGTGAAGAATTACCTTATTCTGTAACCGTTGAAATCGAACGTTTT
GATTACAATCCAAAAATGGATGGTTTCCACATCAATGGTTTGATCCTTGTTGAACGCCATGGCCAGAAAAAAATGGTTAT
TGGTAAGAACGGTGAGAAGATCAAAACTATTGGTCGTGAAGCTCGAATCGATATGGAAGGTTTGTTTGACCGCAAAGTGT
ATTTAGAGCTTTGGGTTAAAGTGAAATCTGGATGGGCTGATGATGAGCGAGCACTTCGTTCTCTAGGTTACATTGACGAT
TTATAG

Upstream 100 bases:

>100_bases
GTATCGTGGCTGGCTTGGATAAGCCGGTTATCGGAAAAGGAAGCAGTCGCCGCAAGGCAGAACAGTCGGCTGCTGACATT
GCATTAGGACAACTTAACTA

Downstream 100 bases:

>100_bases
AAAAAGCAGGGTTCAGATCGGTCGCAAGCTCCCTTAAAGGGTTCAGAAGAGCCGCGGTAGGCATCGAGTCTTACCGCGGC
TCTTCTGAAATCTGCAAGTG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSDEKEFDLDAYFASEKKSEVSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQTTRHRIMGVDTDGDYQAIYV
DTPGLHIEEKRAINRLMNRAANSSLSDVNLVLFLVDGTHWTPDDEMVLNKLKKSEFPTVLLVNKVDNVKDKKDVMTHLQE
MTEKMDFVDVVPISAKTGSNVDVVHKLVREYLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
DYNPKMDGFHINGLILVERHGQKKMVIGKNGEKIKTIGREARIDMEGLFDRKVYLELWVKVKSGWADDERALRSLGYIDD
L

Sequences:

>Translated_321_residues
MSDEKEFDLDAYFASEKKSEVSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQTTRHRIMGVDTDGDYQAIYV
DTPGLHIEEKRAINRLMNRAANSSLSDVNLVLFLVDGTHWTPDDEMVLNKLKKSEFPTVLLVNKVDNVKDKKDVMTHLQE
MTEKMDFVDVVPISAKTGSNVDVVHKLVREYLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
DYNPKMDGFHINGLILVERHGQKKMVIGKNGEKIKTIGREARIDMEGLFDRKVYLELWVKVKSGWADDERALRSLGYIDD
L
>Mature_320_residues
SDEKEFDLDAYFASEKKSEVSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQTTRHRIMGVDTDGDYQAIYVD
TPGLHIEEKRAINRLMNRAANSSLSDVNLVLFLVDGTHWTPDDEMVLNKLKKSEFPTVLLVNKVDNVKDKKDVMTHLQEM
TEKMDFVDVVPISAKTGSNVDVVHKLVREYLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERFD
YNPKMDGFHINGLILVERHGQKKMVIGKNGEKIKTIGREARIDMEGLFDRKVYLELWVKVKSGWADDERALRSLGYIDDL

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=325, Percent_Identity=27.3846153846154, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788919, Length=299, Percent_Identity=73.2441471571906, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI87082120, Length=153, Percent_Identity=30.0653594771242, Blast_Score=68, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24646434, Length=311, Percent_Identity=24.1157556270096, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 36832; Mature: 36700

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEKEFDLDAYFASEKKSEVSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQ
CCCCCCCCHHHHHHCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCC
TTRHRIMGVDTDGDYQAIYVDTPGLHIEEKRAINRLMNRAANSSLSDVNLVLFLVDGTHW
CCHHEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCC
TPDDEMVLNKLKKSEFPTVLLVNKVDNVKDKKDVMTHLQEMTEKMDFVDVVPISAKTGSN
CCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
VDVVHKLVREYLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
HHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
DYNPKMDGFHINGLILVERHGQKKMVIGKNGEKIKTIGREARIDMEGLFDRKVYLELWVK
CCCCCCCCEEECEEEEEEECCCEEEEECCCCCHHHHCCHHHCCCHHHHHCHHEEEHEEEH
VKSGWADDERALRSLGYIDDL
HHCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDEKEFDLDAYFASEKKSEVSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQ
CCCCCCCHHHHHHCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCC
TTRHRIMGVDTDGDYQAIYVDTPGLHIEEKRAINRLMNRAANSSLSDVNLVLFLVDGTHW
CCHHEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCC
TPDDEMVLNKLKKSEFPTVLLVNKVDNVKDKKDVMTHLQEMTEKMDFVDVVPISAKTGSN
CCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
VDVVHKLVREYLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
HHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
DYNPKMDGFHINGLILVERHGQKKMVIGKNGEKIKTIGREARIDMEGLFDRKVYLELWVK
CCCCCCCCEEECEEEEEEECCCEEEEECCCCCHHHHCCHHHCCCHHHHHCHHEEEHEEEH
VKSGWADDERALRSLGYIDDL
HHCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]