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The map label for this gene is lepB [H]

Identifier: 59712695

GI number: 59712695

Start: 2325057

End: 2325959

Strand: Reverse

Name: lepB [H]

Synonym: VF_2088

Alternate gene names: 59712695

Gene position: 2325959-2325057 (Counterclockwise)

Preceding gene: 59712696

Following gene: 59712694

Centisome position: 80.27

GC content: 41.64

Gene sequence:

>903_bases
ATGGCTAACACTTTTTCACTGATATTGGTTCTAGTAACACTGTTTACTGGTGTTATTTGGGCAATTGATAAGTTCGTATG
GGCACCTAAGCGTAAGCAAAAAATTGCGTCGGCACGTGAACAAGCGAACGGGCAAGTTGATGAAGCGACACTTGAAAAAG
TAGCGCCACAACCTGCGTGGATTGAGCAGTCTGTCTCTATTTTTCCTGTAATTGGTATTGTTTTAGTGTTGCGCTCATTT
ATTTATGAGCCGTTCCAGATCCCATCCGGTTCGATGATGCCGACGTTATTGGTTGGTGACTTTATCTTGGTTGAAAAATT
CTCTTATGGAATTAAAGATCCTGTTTGGCGTTCACAACTTGTAGAAACTGGTAAACCAGAACGTGGTGATATTGTTGTAT
TTAAATATCCACCACAACCAAATATCGACTATATTAAACGTGTAGTAGGTGAACCTGGCGATACCGTTATTTATAGCTCA
TCGAAGCAATTGTGTGTGAAGCCAAAAGGTGAAGACCAGTGTAAAATTATTCCATTAACGAATATGAAAGACAGTGAATT
CATGCAAGATCGCACTAATTTAGTTCAATATACTGAACAGTTAGCGAAAGATACAACGCATGATATTTTGGTTAACCCTA
TGCGTTCAGATCGTGTGTCGATGTATCAACCTCGACCAGGTTACAACGAATGGGTAGTACCAGAAGGTAACTACTTTGTG
ATGGGCGACAATCGTGACAACAGTGCTGACAGTCGTTATTGGGGATTTGTTCCTGAAGCGAACTTGGTTGGTAAAGCGGT
CGGGATCTGGATCAGCTTTGAATTTGACCGTGGTAGCGATAGCATGCTGCCTTCCTTTATTCCTACTGGTGTTCGTTTCA
ATCGCATCGGTGGCATAGACTGA

Upstream 100 bases:

>100_bases
GAGTTCTGTAAATTTAAGCTTTATTACAGCTCAAAGAAAGCGATGATCAATGGTCTTCGCTTTCTTTGTTATGCAACACT
AAATAACTTAAGGGAATGTA

Downstream 100 bases:

>100_bases
TTAAAAATATATGAATTCTTCACTACAACGCTTAGAAAAGAAAATTGGCTATCAATTTAAAGATGAAAGTTTTCTTAAGT
TAGCACTGACTCACCGTAGC

Product: leader peptidase (signal peptidase I)

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MANTFSLILVLVTLFTGVIWAIDKFVWAPKRKQKIASAREQANGQVDEATLEKVAPQPAWIEQSVSIFPVIGIVLVLRSF
IYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRSQLVETGKPERGDIVVFKYPPQPNIDYIKRVVGEPGDTVIYSS
SKQLCVKPKGEDQCKIIPLTNMKDSEFMQDRTNLVQYTEQLAKDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFDRGSDSMLPSFIPTGVRFNRIGGID

Sequences:

>Translated_300_residues
MANTFSLILVLVTLFTGVIWAIDKFVWAPKRKQKIASAREQANGQVDEATLEKVAPQPAWIEQSVSIFPVIGIVLVLRSF
IYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRSQLVETGKPERGDIVVFKYPPQPNIDYIKRVVGEPGDTVIYSS
SKQLCVKPKGEDQCKIIPLTNMKDSEFMQDRTNLVQYTEQLAKDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFDRGSDSMLPSFIPTGVRFNRIGGID
>Mature_299_residues
ANTFSLILVLVTLFTGVIWAIDKFVWAPKRKQKIASAREQANGQVDEATLEKVAPQPAWIEQSVSIFPVIGIVLVLRSFI
YEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRSQLVETGKPERGDIVVFKYPPQPNIDYIKRVVGEPGDTVIYSSS
KQLCVKPKGEDQCKIIPLTNMKDSEFMQDRTNLVQYTEQLAKDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFVM
GDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFDRGSDSMLPSFIPTGVRFNRIGGID

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=330, Percent_Identity=52.7272727272727, Blast_Score=332, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 33898; Mature: 33767

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTFSLILVLVTLFTGVIWAIDKFVWAPKRKQKIASAREQANGQVDEATLEKVAPQPAW
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHH
IEQSVSIFPVIGIVLVLRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRSQL
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
VETGKPERGDIVVFKYPPQPNIDYIKRVVGEPGDTVIYSSSKQLCVKPKGEDQCKIIPLT
HHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCEEEEECC
NMKDSEFMQDRTNLVQYTEQLAKDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
CCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCEEECCCCCCCCEEECCCCEEE
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFDRGSDSMLPSFIPTGVRFNRIGGID
EECCCCCCCCCCEECCCCCCHHHCEEEEEEEEEEECCCCCCCCHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
ANTFSLILVLVTLFTGVIWAIDKFVWAPKRKQKIASAREQANGQVDEATLEKVAPQPAW
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHH
IEQSVSIFPVIGIVLVLRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRSQL
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
VETGKPERGDIVVFKYPPQPNIDYIKRVVGEPGDTVIYSSSKQLCVKPKGEDQCKIIPLT
HHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCEEEEECC
NMKDSEFMQDRTNLVQYTEQLAKDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
CCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCEEECCCCCCCCEEECCCCEEE
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFDRGSDSMLPSFIPTGVRFNRIGGID
EECCCCCCCCCCEECCCCCCHHHCEEEEEEEEEEECCCCCCCCHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]