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The map label for this gene is nhaB [H]

Identifier: 59712241

GI number: 59712241

Start: 1837194

End: 1838786

Strand: Direct

Name: nhaB [H]

Synonym: VF_1634

Alternate gene names: 59712241

Gene position: 1837194-1838786 (Clockwise)

Preceding gene: 59712238

Following gene: 59712242

Centisome position: 63.41

GC content: 38.92

Gene sequence:

>1593_bases
ATGTCTATTTCGCTAGGGAATGCATTTATCAAAAACTTTCTTGGTAAAGCCCCCGATTGGTACAAAATCGCAATACTTTC
ATTTCTTGTAATCAACCCACTTGTTTTCTTCTTTGTAGATCCGTTTACTGCAGGTTGGTTGCTGGTTGTTGAATTCATTT
TTACTCTTGCAATGGCGTTAAAATGTTACCCATTACAGCCTGGCGGTTTATTAGCTATAGAAGCAATTGCCATTGGTATG
ACAAGCCCTGAGCAAGTAAAACATGAACTAGTAGCCAATATCGAAGTACTTTTACTACTCGTATTCATGGTTGCTGGTAT
CTACTTCATGAAGCAATTGCTTCTATTTATCTTTACTAAAATACTCATTGGTATTAAGTCTAAAACTGCTTTATCAGTGG
CATTCTGTTTTACCGCTGCATTTTTATCAGCTTTCCTTGATGCCTTAACAGTAATTGCTGTTGTAATTAGTGTTGCTGTT
GGTTTCTATGCAATTTATCACCGTGTTGCATCTGGCCAAGGTGGTTCACAAACTCACGACCATACTTGTGATAGCGATGT
TGATGAATTAACACGTGAAGATTTAGAAGACTACCGTGCTTTTTTACGTAGCCTATTAATGCACGCAGGGGTAGGTACCG
CACTTGGTGGTGTAATGACAATGGTGGGCGAACCACAAAACTTGATCATTGCAGACCAAGCAGGTTGGATGTTTGGTGAA
TTCATTATCCGCATGCTTCCAATTACAGCGCCAGTATTTATCTGTGGTATTTTAACTTGTATCGCTGTTGAAAAATTAGG
TATTTGTGGCTACGGTGCAAAATTGCCTGAAAACGTACGTAAAATCCTAGAAGACTACGAAGCAGAAGAACGTAAAAACC
GTACTAATATCGATAACGCTAAATTAATCATCCAAGGTTTAATTGCGGTATGGCTAATTGTTGGTTTAGCACTTCATCTT
GCTGCCGTTGGTCTAATTGGCTTATCAGTGATTATCCTTGCAACTGCATTTACAGGTGTGATTGAAGAACACTCTATGGG
TAAAGCGTTTGAAGAGGCTCTGCCATTCACCGCCCTATTAGCCGTATTCTTTGCCGTTGTAGCTGTAATCATTGACCAAG
AGCTATTTAAACCAATCATTGACGCTGTACTTGCAGTAGAAGATAAAGGTGCACAATTAGCACTGTTCTATGTAGCAAAT
GGCTTACTTTCTATGGTATCTGATAACGTATTCGTTGGTACAGTTTACATTAATGAAGTAAAAGCAGCATTAATGGATGG
TGTTATTACACGTGATCAATTTGATCTACTAGCTGTAGCTATCAATACAGGTACAAATTTACCATCTGTTGCTACACCAA
ACGGTCAAGCAGCTTTCCTATTCTTATTAACGTCTGCTCTTGCTCCGTTAATTCAATTATCATACGGCCGTATGGTATGG
ATGGCTCTTCCTTATACAATTGTGTTAGCACTAGTTGGTATGTTTGGTATCATTTTCTTCCTTGAACCTATGACAGCAAT
GTTCTACGATCTTGGTTGGATTGCACCTGGAACAATAGAAAGTGCAACTTCTGCGATTTCTAGTGGTCATTAA

Upstream 100 bases:

>100_bases
AGTTGTTTATCTTTACTAATAACAATATGTTAGGCGATTATTATCAACTCCCTACTTAACCTTATTTTTAGAATTATCGT
AATAATGTAGAGAGCATCAC

Downstream 100 bases:

>100_bases
TAAGGTAAACTACTTTTGATAGCAAAGGCTCTGTAGATACGGGGCCTTTATTTTTATAAGGAATAAAAATGCAAGCCCTT
AATCACTTCTCACGCATTCG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSISLGNAFIKNFLGKAPDWYKIAILSFLVINPLVFFFVDPFTAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAIAIGM
TSPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAV
GFYAIYHRVASGQGGSQTHDHTCDSDVDELTREDLEDYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQAGWMFGE
FIIRMLPITAPVFICGILTCIAVEKLGICGYGAKLPENVRKILEDYEAEERKNRTNIDNAKLIIQGLIAVWLIVGLALHL
AAVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFAVVAVIIDQELFKPIIDAVLAVEDKGAQLALFYVAN
GLLSMVSDNVFVGTVYINEVKAALMDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMVW
MALPYTIVLALVGMFGIIFFLEPMTAMFYDLGWIAPGTIESATSAISSGH

Sequences:

>Translated_530_residues
MSISLGNAFIKNFLGKAPDWYKIAILSFLVINPLVFFFVDPFTAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAIAIGM
TSPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAV
GFYAIYHRVASGQGGSQTHDHTCDSDVDELTREDLEDYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQAGWMFGE
FIIRMLPITAPVFICGILTCIAVEKLGICGYGAKLPENVRKILEDYEAEERKNRTNIDNAKLIIQGLIAVWLIVGLALHL
AAVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFAVVAVIIDQELFKPIIDAVLAVEDKGAQLALFYVAN
GLLSMVSDNVFVGTVYINEVKAALMDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMVW
MALPYTIVLALVGMFGIIFFLEPMTAMFYDLGWIAPGTIESATSAISSGH
>Mature_529_residues
SISLGNAFIKNFLGKAPDWYKIAILSFLVINPLVFFFVDPFTAGWLLVVEFIFTLAMALKCYPLQPGGLLAIEAIAIGMT
SPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAVG
FYAIYHRVASGQGGSQTHDHTCDSDVDELTREDLEDYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQAGWMFGEF
IIRMLPITAPVFICGILTCIAVEKLGICGYGAKLPENVRKILEDYEAEERKNRTNIDNAKLIIQGLIAVWLIVGLALHLA
AVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFAVVAVIIDQELFKPIIDAVLAVEDKGAQLALFYVANG
LLSMVSDNVFVGTVYINEVKAALMDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMVWM
ALPYTIVLALVGMFGIIFFLEPMTAMFYDLGWIAPGTIESATSAISSGH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=515, Percent_Identity=68.5436893203884, Blast_Score=682, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 57307; Mature: 57175

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISLGNAFIKNFLGKAPDWYKIAILSFLVINPLVFFFVDPFTAGWLLVVEFIFTLAMAL
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
KCYPLQPGGLLAIEAIAIGMTSPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTK
HCCCCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAVGFYAIYHRVASGQGGSQTHD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HTCDSDVDELTREDLEDYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQAGWMFGE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHH
FIIRMLPITAPVFICGILTCIAVEKLGICGYGAKLPENVRKILEDYEAEERKNRTNIDNA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHH
KLIIQGLIAVWLIVGLALHLAAVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AVFFAVVAVIIDQELFKPIIDAVLAVEDKGAQLALFYVANGLLSMVSDNVFVGTVYINEV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEEHHHHH
KAALMDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMVW
HHHHHHCHHCCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHH
MALPYTIVLALVGMFGIIFFLEPMTAMFYDLGWIAPGTIESATSAISSGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SISLGNAFIKNFLGKAPDWYKIAILSFLVINPLVFFFVDPFTAGWLLVVEFIFTLAMAL
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
KCYPLQPGGLLAIEAIAIGMTSPEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTK
HCCCCCCCCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAVGFYAIYHRVASGQGGSQTHD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HTCDSDVDELTREDLEDYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQAGWMFGE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHH
FIIRMLPITAPVFICGILTCIAVEKLGICGYGAKLPENVRKILEDYEAEERKNRTNIDNA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHH
KLIIQGLIAVWLIVGLALHLAAVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AVFFAVVAVIIDQELFKPIIDAVLAVEDKGAQLALFYVANGLLSMVSDNVFVGTVYINEV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEEHHHHH
KAALMDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMVW
HHHHHHCHHCCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHH
MALPYTIVLALVGMFGIIFFLEPMTAMFYDLGWIAPGTIESATSAISSGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA