Click here to switch to the map view.

The map label for this gene is ppiB [H]

Identifier: 59711705

GI number: 59711705

Start: 1213085

End: 1213624

Strand: Reverse

Name: ppiB [H]

Synonym: VF_1098

Alternate gene names: 59711705

Gene position: 1213624-1213085 (Counterclockwise)

Preceding gene: 59711706

Following gene: 59711704

Centisome position: 41.88

GC content: 36.3

Gene sequence:

>540_bases
ATGCTATTTTCAAAGAATTTAAAATTAATTAAGAACAAAATTATGATCATTTTTACTACCAACTTTGGTGATATTCACAT
TGAGCTAAACAAAGAGAAAGCCCCTGTTAGCTCAAAGAACTTTTTAAAATATTGCCAAGATGGTTTCTACGAAGGCACCA
TTTTTCACCGAGTTATCAAAGGATTTATGATTCAAGGCGGCGGTTTTACTGCTGATATGCAAGAAAAAGAAATGCGTGCA
CCTATCGTTAATGAAGCGAATCGCGGTTTAAAGAATTTAAACGGTACAATTGCAATGGCACGTACCGATGCCCCTCATTC
TGCAACAAGCGAATTTTTTATTAATATTGCTAACAATACGTTCCTTGACCATACAGCAACTACCAATGCAGGTTGGGGTT
ATGCTGTATTTGGCGAAGTAACAATGGGCATGGATGTGGTTAAGAAAATAGCCAAAATTAAAACTAAATCCATCGGTGAG
TTTGACGATGTTCCAAAAGAGAGTATTGTTATCGAGAAAGTGACTATCGTAGGCGAATAA

Upstream 100 bases:

>100_bases
ATCTGGAACGACAAACACCAACCTATAATCATTAGTATTTACTTAACTCAAACAAAGCTTGATATGGCTGAACGTAATCA
AGTTATTGTTGAAGTTGGTA

Downstream 100 bases:

>100_bases
CCCCCGAAATCACCCGATAAAACAAAAAACGGTGCTAATTACAGCACCGTTTTCGATCGCCCCTCTAATTGATTTTTCTG
GGACAATACAAATAACCTAA

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MLFSKNLKLIKNKIMIIFTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQEKEMRA
PIVNEANRGLKNLNGTIAMARTDAPHSATSEFFINIANNTFLDHTATTNAGWGYAVFGEVTMGMDVVKKIAKIKTKSIGE
FDDVPKESIVIEKVTIVGE

Sequences:

>Translated_179_residues
MLFSKNLKLIKNKIMIIFTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQEKEMRA
PIVNEANRGLKNLNGTIAMARTDAPHSATSEFFINIANNTFLDHTATTNAGWGYAVFGEVTMGMDVVKKIAKIKTKSIGE
FDDVPKESIVIEKVTIVGE
>Mature_179_residues
MLFSKNLKLIKNKIMIIFTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQEKEMRA
PIVNEANRGLKNLNGTIAMARTDAPHSATSEFFINIANNTFLDHTATTNAGWGYAVFGEVTMGMDVVKKIAKIKTKSIGE
FDDVPKESIVIEKVTIVGE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=172, Percent_Identity=31.9767441860465, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7657473, Length=172, Percent_Identity=31.9767441860465, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI22547215, Length=172, Percent_Identity=31.9767441860465, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=33.1288343558282, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI19557636, Length=162, Percent_Identity=32.0987654320988, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=34.8837209302326, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706339, Length=170, Percent_Identity=32.3529411764706, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI5031987, Length=142, Percent_Identity=35.2112676056338, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI5174637, Length=155, Percent_Identity=31.6129032258064, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI310110104, Length=141, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=58.0246913580247, Blast_Score=197, Evalue=3e-52,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=55.1282051282051, Blast_Score=183, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17532641, Length=170, Percent_Identity=31.7647058823529, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=36.6197183098592, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=36.1111111111111, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=168, Percent_Identity=33.9285714285714, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=161, Percent_Identity=31.6770186335404, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=129, Percent_Identity=32.5581395348837, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=34.7517730496454, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=174, Percent_Identity=29.8850574712644, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=182, Percent_Identity=32.4175824175824, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=29.4478527607362, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922376, Length=177, Percent_Identity=28.2485875706215, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922912, Length=154, Percent_Identity=33.7662337662338, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45549139, Length=142, Percent_Identity=36.6197183098592, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647301, Length=155, Percent_Identity=34.1935483870968, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664125, Length=157, Percent_Identity=32.484076433121, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357783, Length=157, Percent_Identity=32.484076433121, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19917; Mature: 19917

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSKNLKLIKNKIMIIFTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIK
CCCCCCHHEEECCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
GFMIQGGGFTADMQEKEMRAPIVNEANRGLKNLNGTIAMARTDAPHSATSEFFINIANNT
HHEECCCCCCCCCCHHHHCCCCHHHHHCCHHHCCCEEEEEECCCCCCCCCEEEEEECCCE
FLDHTATTNAGWGYAVFGEVTMGMDVVKKIAKIKTKSIGEFDDVPKESIVIEKVTIVGE
EECCCCCCCCCCCEEEECCHHHCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MLFSKNLKLIKNKIMIIFTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIK
CCCCCCHHEEECCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
GFMIQGGGFTADMQEKEMRAPIVNEANRGLKNLNGTIAMARTDAPHSATSEFFINIANNT
HHEECCCCCCCCCCHHHHCCCCHHHHHCCHHHCCCEEEEEECCCCCCCCCEEEEEECCCE
FLDHTATTNAGWGYAVFGEVTMGMDVVKKIAKIKTKSIGEFDDVPKESIVIEKVTIVGE
EECCCCCCCCCCCEEEECCHHHCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]