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The map label for this gene is trpC [H]

Identifier: 59711636

GI number: 59711636

Start: 1133692

End: 1135104

Strand: Reverse

Name: trpC [H]

Synonym: VF_1029

Alternate gene names: 59711636

Gene position: 1135104-1133692 (Counterclockwise)

Preceding gene: 172087685

Following gene: 59711635

Centisome position: 39.17

GC content: 38.36

Gene sequence:

>1413_bases
ATGACACAGCAATTGTCTGAACACATCTCAGTAGAAAATACAAAAATGGCTGAAGTGCTTGTAAAAATAGTAAAAGACAA
AGCCATTTGGGTCGAAGAGCGTAAGAAACAACAACCTCTCGATGATTTTCAATCGTCATTAAGTCTATCTGACCGTAGCT
TTTACGACGCATTAAAAACAGGCAAAACCGAATTTATCCTTGAATGTAAAAAAGCCTCACCATCAAAAGGATTAATTCGA
GATGATTTCGATCTCAATTACATTGCTTCTGTCTACAATAATCACGCGAGTGCCATTTCTGTACTAACTGATGAAAAGTA
TTTCCAAGGTAACTTTGATTTCTTACCTATTATTCGAAATCAAGTGTCACAGCCTATTTTATGTAAAGATTTCATGATAG
ATGCTTATCAAGTGTATCTTGCTCGTCATTACTCTGCTGATGCCATTTTATTAATGCTTTCTGTTTTAGATGATGCGCAG
TACAAAGAACTTGCAGACATAGCACATTCATTAAACATGGGTATTTTAACGGAAGTCAGCAATGAAGAAGAATTGCATCG
TGCAGTGGCATTAAACGCAAAAGTCATTGGAATTAACAACCGTAACCTACGTGACTTATCAACAGATTTAAATAGAACAA
AAGAACTAGCTCCTCTACTGCCTAAAGGTACAACCATTATTTCTGAGTCAGGTATTTATACTCATCAACAAGTAAAAGAT
CTGGCTCAGCACGCTTCAGGCTTTCTGATTGGTAGCTCACTAATGGCAGAAAAAAACCTAGAGCTTGCAGCAAGAAAAGT
TATTTTAGGTGAAAACAAAGTCTGTGGATTAACTTCAGAGCAAGATGCGAAAGCCGTTTATGACTCTGGAGCTGTCTACG
GCGGACTTATTTTCGTAGAAAAATCACCACGTTTTGTTTCTTTTGAAACCGCAAAGAAAATAACCCAAGCAACTGCATTA
CATTATGTGGGCGTTTTCCAAAATGAGGATGTTCAGCGTGTTGCTCAGTACGCCACTGACCTTTCTCTATCTGTGATTCA
ACTGCATGGAAATGAAACCGAAGAGTATATTACTGAGTTAGCCTCTTTATTACCGACTCACACTCAAATTTGGAATGTCA
TTTCTGTGTCAGATGATGCTCAAAGCATTTCACTTCCACAAACTCAAGCTGATAAGGTGTTAGTTGATTGTAAAGTAGGT
TCGCAGGTGGGAGGCACTGGCGTAAGTTTTGATTGGAATAAACTGCCTCACCACAGCATCATGCTTGCCGGTGGACTTGA
ATTAAATAATACCAAACAAGCAGCGCAACTCGGCTGCTACGGATTAGATTTCAACTCAGGAGTAGAAAGTACTCCGGGTA
AAAAAGATCATAAAAAATTAAGCGCCGTATTTAGCGCATTACGAGACTATTAA

Upstream 100 bases:

>100_bases
CATGAAGATCTAAAAGCTAATGCACAAAAAGCCATCGATGCCATGAATTCAGGTAAAGCCTTCGAATTGGTACAACAACT
GGCTGCAAGAGGATAAATGA

Downstream 100 bases:

>100_bases
GGAAAATATCATGGCAAAATTAGATGCCTACTTCGGCGAATACGGTGGTCAATACGTTCCACAGATTTTAGTTCCAGCTT
TAGAGCAACTAGAACAAGCC

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTQQLSEHISVENTKMAEVLVKIVKDKAIWVEERKKQQPLDDFQSSLSLSDRSFYDALKTGKTEFILECKKASPSKGLIR
DDFDLNYIASVYNNHASAISVLTDEKYFQGNFDFLPIIRNQVSQPILCKDFMIDAYQVYLARHYSADAILLMLSVLDDAQ
YKELADIAHSLNMGILTEVSNEEELHRAVALNAKVIGINNRNLRDLSTDLNRTKELAPLLPKGTTIISESGIYTHQQVKD
LAQHASGFLIGSSLMAEKNLELAARKVILGENKVCGLTSEQDAKAVYDSGAVYGGLIFVEKSPRFVSFETAKKITQATAL
HYVGVFQNEDVQRVAQYATDLSLSVIQLHGNETEEYITELASLLPTHTQIWNVISVSDDAQSISLPQTQADKVLVDCKVG
SQVGGTGVSFDWNKLPHHSIMLAGGLELNNTKQAAQLGCYGLDFNSGVESTPGKKDHKKLSAVFSALRDY

Sequences:

>Translated_470_residues
MTQQLSEHISVENTKMAEVLVKIVKDKAIWVEERKKQQPLDDFQSSLSLSDRSFYDALKTGKTEFILECKKASPSKGLIR
DDFDLNYIASVYNNHASAISVLTDEKYFQGNFDFLPIIRNQVSQPILCKDFMIDAYQVYLARHYSADAILLMLSVLDDAQ
YKELADIAHSLNMGILTEVSNEEELHRAVALNAKVIGINNRNLRDLSTDLNRTKELAPLLPKGTTIISESGIYTHQQVKD
LAQHASGFLIGSSLMAEKNLELAARKVILGENKVCGLTSEQDAKAVYDSGAVYGGLIFVEKSPRFVSFETAKKITQATAL
HYVGVFQNEDVQRVAQYATDLSLSVIQLHGNETEEYITELASLLPTHTQIWNVISVSDDAQSISLPQTQADKVLVDCKVG
SQVGGTGVSFDWNKLPHHSIMLAGGLELNNTKQAAQLGCYGLDFNSGVESTPGKKDHKKLSAVFSALRDY
>Mature_469_residues
TQQLSEHISVENTKMAEVLVKIVKDKAIWVEERKKQQPLDDFQSSLSLSDRSFYDALKTGKTEFILECKKASPSKGLIRD
DFDLNYIASVYNNHASAISVLTDEKYFQGNFDFLPIIRNQVSQPILCKDFMIDAYQVYLARHYSADAILLMLSVLDDAQY
KELADIAHSLNMGILTEVSNEEELHRAVALNAKVIGINNRNLRDLSTDLNRTKELAPLLPKGTTIISESGIYTHQQVKDL
AQHASGFLIGSSLMAEKNLELAARKVILGENKVCGLTSEQDAKAVYDSGAVYGGLIFVEKSPRFVSFETAKKITQATALH
YVGVFQNEDVQRVAQYATDLSLSVIQLHGNETEEYITELASLLPTHTQIWNVISVSDDAQSISLPQTQADKVLVDCKVGS
QVGGTGVSFDWNKLPHHSIMLAGGLELNNTKQAAQLGCYGLDFNSGVESTPGKKDHKKLSAVFSALRDY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=461, Percent_Identity=59.8698481561822, Blast_Score=551, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322638, Length=237, Percent_Identity=35.0210970464135, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320210, Length=216, Percent_Identity=31.0185185185185, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 52015; Mature: 51883

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQLSEHISVENTKMAEVLVKIVKDKAIWVEERKKQQPLDDFQSSLSLSDRSFYDALKT
CCCHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHC
GKTEFILECKKASPSKGLIRDDFDLNYIASVYNNHASAISVLTDEKYFQGNFDFLPIIRN
CCCEEEEEECCCCCCCCCEECCCCHHHHHHHHCCCCCEEEEEECCHHCCCCCCCHHHHHH
QVSQPILCKDFMIDAYQVYLARHYSADAILLMLSVLDDAQYKELADIAHSLNMGILTEVS
HCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECC
NEEELHRAVALNAKVIGINNRNLRDLSTDLNRTKELAPLLPKGTTIISESGIYTHQQVKD
CHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
LAQHASGFLIGSSLMAEKNLELAARKVILGENKVCGLTSEQDAKAVYDSGAVYGGLIFVE
HHHHHCCEEEEHHHHHHCCHHHHHHHHEECCCCEECCCCCCHHHHHHCCCCEEEEEEEEE
KSPRFVSFETAKKITQATALHYVGVFQNEDVQRVAQYATDLSLSVIQLHGNETEEYITEL
CCCCEEEHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
ASLLPTHTQIWNVISVSDDAQSISLPQTQADKVLVDCKVGSQVGGTGVSFDWNKLPHHSI
HHHCCCHHHHEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEE
MLAGGLELNNTKQAAQLGCYGLDFNSGVESTPGKKDHKKLSAVFSALRDY
EEECCCEECCCHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQQLSEHISVENTKMAEVLVKIVKDKAIWVEERKKQQPLDDFQSSLSLSDRSFYDALKT
CCHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHC
GKTEFILECKKASPSKGLIRDDFDLNYIASVYNNHASAISVLTDEKYFQGNFDFLPIIRN
CCCEEEEEECCCCCCCCCEECCCCHHHHHHHHCCCCCEEEEEECCHHCCCCCCCHHHHHH
QVSQPILCKDFMIDAYQVYLARHYSADAILLMLSVLDDAQYKELADIAHSLNMGILTEVS
HCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECC
NEEELHRAVALNAKVIGINNRNLRDLSTDLNRTKELAPLLPKGTTIISESGIYTHQQVKD
CHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
LAQHASGFLIGSSLMAEKNLELAARKVILGENKVCGLTSEQDAKAVYDSGAVYGGLIFVE
HHHHHCCEEEEHHHHHHCCHHHHHHHHEECCCCEECCCCCCHHHHHHCCCCEEEEEEEEE
KSPRFVSFETAKKITQATALHYVGVFQNEDVQRVAQYATDLSLSVIQLHGNETEEYITEL
CCCCEEEHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
ASLLPTHTQIWNVISVSDDAQSISLPQTQADKVLVDCKVGSQVGGTGVSFDWNKLPHHSI
HHHCCCHHHHEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEE
MLAGGLELNNTKQAAQLGCYGLDFNSGVESTPGKKDHKKLSAVFSALRDY
EEECCCEECCCHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]