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The map label for this gene is uvrB [H]

Identifier: 59711543

GI number: 59711543

Start: 1031186

End: 1033216

Strand: Direct

Name: uvrB [H]

Synonym: VF_0936

Alternate gene names: 59711543

Gene position: 1031186-1033216 (Clockwise)

Preceding gene: 59711533

Following gene: 59711544

Centisome position: 35.59

GC content: 38.6

Gene sequence:

>2031_bases
ATGTCTAGTGCGTATGAACTCGTATCTAATTATCAACCTGCGGGCGATCAACCTCAAGCGATAAAAACACTTAATGAAGG
TCTTGAGAATGGGTTAGCTCATCAAACGTTATTGGGAGTTACTGGTTCAGGTAAAACATTTACTCTCGCTAATGTTATTG
CTCATTCTGGTCGCCCGACGATCATTATGGCTCATAACAAAACATTAGCAGCTCAGTTATACGGTGAAATGAAAGCTTTC
TTTCCAAATAACGCTGTTGAATATTTTGTTTCTTATTTTGATTATTACCAACCAGAAGCCTATGTACCAACGACGGATAC
ATTTATAGAAAAAGACTCATCGGTTAATGAGCACATTGAGCAAATGCGTTTATCAGCAACCAAAGCATTATTAGAGCGTA
AAGATGCGATTATTATTGCTTCAGTTTCTGCAATATATGGCTTAGGTGATCCAAAAGCCTATTTGAGTATGATACTGCAC
TTACGCCGTGGTGACATTATTAATCAAAGAGACATGTTGCGTCGTTTAGCCGAATTGCAATATAAGCGTAATGACATGGC
TTTTGAACGAGGCACATTTCGAGTTCGTGGAGAAGTATTGGATATTTTCCCAGCAGAGTCTGAACATGAAGCCATTCGTA
TTGAAATGTTTGATGATGAAGTTGAGCGTATTAGTAAATTTGATCCACTAACAGGATCAATCATAACGAAAGATATGCCA
CGTTGTACTATCTACCCTAAAACGCACTATGTAACCCCTCGTGAGCAGGTCTTAGATGCGATCGAAAAGATCAAAGTTGA
TCTTGCTATTAGACAAAAAGAATTGCTAGAAAATAACAAGCTTGTTGAAGAACAACGTATCACTCAACGGACTCAATTTG
ATATTGAAATGATGAACGAATTGGGTTTTTGCTCAGGTATAGAAAACTATTCACGTTATTTGAGTGGACGTCCGGAAGGT
GAAGCACCACCAACCTTGTTTGATTATTTACCACAAGATGGCCTATTAATTATCGATGAATCTCATATAACCGTTTCTCA
AATTGGTGCTATGTATAAGGGTGACCGCTCACGTAAAGAGAATTTAGTTGAGTATGGATTCAGATTACCGTCAGCTTTGG
ATAATCGTCCGCTACGATTTGAAGAATTTGAAGCATTAGCGCCTCAGACTATTTATGTCTCAGCCACACCGGGTAAATAT
GAGATTGAAAAGTCAGATGGTGAAATTGCAGAGCAAGTAGTACGTCCAACTGGATTATTAGACCCTGTAATTGAAGTTCG
CCCAGTAGCAACACAAGTTGATGATTTATTATCTGAGATCCGTATACGAACTAAAAATAATGAACGAGTATTAGTGACAA
CACTGACGAAGCGTATGGCTGAAGACTTAACGGAATATCTTGATGAGCATGGCGTAAAAGTTCGTTATTTACACTCAGAT
ATTGATACGGTTGAGCGTGTCGAAATTATACGTGATTTACGCTTAGGTGAGTTTGATGTCCTTGTTGGTATTAACTTACT
TCGAGAAGGTCTAGACATGCCTGAGGTTTCATTGGTTGCGATTTTAGATGCAGATAAAGAAGGATTTTTACGTTCTGAAC
GTTCGCTAATTCAAACGATTGGTCGCGCTGCTCGTAACTTAGAGGGTAAAGCCATTCTTTACGCTGATAAGATCACAGGT
TCAATGGAAAAAGCCATTGGTGAAACAGAAAGACGCAGAGAGAAGCAACAATTACACAATGAAACGTTAGGTATTGTTCC
ACAAGCGCTTAAGAAAGACGTTGCCGATATTCTTGAATTGGGTGATATGACTAAAAATAAACGTAAAGTTGTTGCACCTA
AGATTAAGTTATCGGAAGTTGCAGAAGAAGGCGCTAGTTACAGTGCGATGTCGCCACAGCAGTTAGAAAAGGCGATTCAG
AAGCTAGAAAGTAAGATGTATCAACATGCGAAAGACTTGGAATTTGAACAAGCGGCACAAGTTCGAGATGAGATTGATAA
TTTAAGAAAACAATTTATAGTGAATAGTTAG

Upstream 100 bases:

>100_bases
TGGGGAAAACTTTTCTTATTTAAGAGTTTCTATAAAAAAGGGAAGGGATTTGATAGGGTAGTGTCTTATAAAAATAAGTA
GGAAAGTGGAGCAGTATAAA

Downstream 100 bases:

>100_bases
TTATTGATTTTATAGCAGAAAAAAAGAAGCCAACCGCAATATCCCGGTTGGCTTTATTGTTCATGTGAAAGTAAATTTCA
CTAACAACGTCAGTTGGCTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MSSAYELVSNYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAHSGRPTIIMAHNKTLAAQLYGEMKAF
FPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIEQMRLSATKALLERKDAIIIASVSAIYGLGDPKAYLSMILH
LRRGDIINQRDMLRRLAELQYKRNDMAFERGTFRVRGEVLDIFPAESEHEAIRIEMFDDEVERISKFDPLTGSIITKDMP
RCTIYPKTHYVTPREQVLDAIEKIKVDLAIRQKELLENNKLVEEQRITQRTQFDIEMMNELGFCSGIENYSRYLSGRPEG
EAPPTLFDYLPQDGLLIIDESHITVSQIGAMYKGDRSRKENLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGKY
EIEKSDGEIAEQVVRPTGLLDPVIEVRPVATQVDDLLSEIRIRTKNNERVLVTTLTKRMAEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGKAILYADKITG
SMEKAIGETERRREKQQLHNETLGIVPQALKKDVADILELGDMTKNKRKVVAPKIKLSEVAEEGASYSAMSPQQLEKAIQ
KLESKMYQHAKDLEFEQAAQVRDEIDNLRKQFIVNS

Sequences:

>Translated_676_residues
MSSAYELVSNYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAHSGRPTIIMAHNKTLAAQLYGEMKAF
FPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIEQMRLSATKALLERKDAIIIASVSAIYGLGDPKAYLSMILH
LRRGDIINQRDMLRRLAELQYKRNDMAFERGTFRVRGEVLDIFPAESEHEAIRIEMFDDEVERISKFDPLTGSIITKDMP
RCTIYPKTHYVTPREQVLDAIEKIKVDLAIRQKELLENNKLVEEQRITQRTQFDIEMMNELGFCSGIENYSRYLSGRPEG
EAPPTLFDYLPQDGLLIIDESHITVSQIGAMYKGDRSRKENLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGKY
EIEKSDGEIAEQVVRPTGLLDPVIEVRPVATQVDDLLSEIRIRTKNNERVLVTTLTKRMAEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGKAILYADKITG
SMEKAIGETERRREKQQLHNETLGIVPQALKKDVADILELGDMTKNKRKVVAPKIKLSEVAEEGASYSAMSPQQLEKAIQ
KLESKMYQHAKDLEFEQAAQVRDEIDNLRKQFIVNS
>Mature_675_residues
SSAYELVSNYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAHSGRPTIIMAHNKTLAAQLYGEMKAFF
PNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIEQMRLSATKALLERKDAIIIASVSAIYGLGDPKAYLSMILHL
RRGDIINQRDMLRRLAELQYKRNDMAFERGTFRVRGEVLDIFPAESEHEAIRIEMFDDEVERISKFDPLTGSIITKDMPR
CTIYPKTHYVTPREQVLDAIEKIKVDLAIRQKELLENNKLVEEQRITQRTQFDIEMMNELGFCSGIENYSRYLSGRPEGE
APPTLFDYLPQDGLLIIDESHITVSQIGAMYKGDRSRKENLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGKYE
IEKSDGEIAEQVVRPTGLLDPVIEVRPVATQVDDLLSEIRIRTKNNERVLVTTLTKRMAEDLTEYLDEHGVKVRYLHSDI
DTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGKAILYADKITGS
MEKAIGETERRREKQQLHNETLGIVPQALKKDVADILELGDMTKNKRKVVAPKIKLSEVAEEGASYSAMSPQQLEKAIQK
LESKMYQHAKDLEFEQAAQVRDEIDNLRKQFIVNS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=677, Percent_Identity=74.7415066469719, Blast_Score=1019, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76772; Mature: 76640

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAYELVSNYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAHSGRPT
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHEEECCCCCEEEHHHHHHCCCCCE
IIMAHNKTLAAQLYGEMKAFFPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIE
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHH
QMRLSATKALLERKDAIIIASVSAIYGLGDPKAYLSMILHLRRGDIINQRDMLRRLAELQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YKRNDMAFERGTFRVRGEVLDIFPAESEHEAIRIEMFDDEVERISKFDPLTGSIITKDMP
HHHCCHHHHCCCEEEECCEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHCCCCC
RCTIYPKTHYVTPREQVLDAIEKIKVDLAIRQKELLENNKLVEEQRITQRTQFDIEMMNE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRPEGEAPPTLFDYLPQDGLLIIDESHITVSQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCEEHHHHHHHHCCCCHHHH
NLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGKYEIEKSDGEIAEQVVRPTGLL
HHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHCCCCCC
DPVIEVRPVATQVDDLLSEIRIRTKNNERVLVTTLTKRMAEDLTEYLDEHGVKVRYLHSD
CCHHHHHHHHHHHHHHHHHHEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLEGKAILYADKITGSMEKAIGETERRREKQQLHNETLGIVPQALKKDVADILEL
HHHHHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GDMTKNKRKVVAPKIKLSEVAEEGASYSAMSPQQLEKAIQKLESKMYQHAKDLEFEQAAQ
HCCCCCCCEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VRDEIDNLRKQFIVNS
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSAYELVSNYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAHSGRPT
CCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHEEECCCCCEEEHHHHHHCCCCCE
IIMAHNKTLAAQLYGEMKAFFPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIE
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHH
QMRLSATKALLERKDAIIIASVSAIYGLGDPKAYLSMILHLRRGDIINQRDMLRRLAELQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YKRNDMAFERGTFRVRGEVLDIFPAESEHEAIRIEMFDDEVERISKFDPLTGSIITKDMP
HHHCCHHHHCCCEEEECCEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHCCCCC
RCTIYPKTHYVTPREQVLDAIEKIKVDLAIRQKELLENNKLVEEQRITQRTQFDIEMMNE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRPEGEAPPTLFDYLPQDGLLIIDESHITVSQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCEEHHHHHHHHCCCCHHHH
NLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGKYEIEKSDGEIAEQVVRPTGLL
HHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHCCCCCC
DPVIEVRPVATQVDDLLSEIRIRTKNNERVLVTTLTKRMAEDLTEYLDEHGVKVRYLHSD
CCHHHHHHHHHHHHHHHHHHEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLEGKAILYADKITGSMEKAIGETERRREKQQLHNETLGIVPQALKKDVADILEL
HHHHHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GDMTKNKRKVVAPKIKLSEVAEEGASYSAMSPQQLEKAIQKLESKMYQHAKDLEFEQAAQ
HCCCCCCCEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VRDEIDNLRKQFIVNS
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA