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The map label for this gene is pgm [H]

Identifier: 59711423

GI number: 59711423

Start: 894447

End: 896093

Strand: Direct

Name: pgm [H]

Synonym: VF_0816

Alternate gene names: 59711423

Gene position: 894447-896093 (Clockwise)

Preceding gene: 59711422

Following gene: 59711424

Centisome position: 30.87

GC content: 40.38

Gene sequence:

>1647_bases
ATGGCTATACATCCTCGTGCTGGGCAGAAAGCTCAGCAAGAAGATTTACACAATATCCCATCATTAGTTGCTAATTATTT
CTTATTAGAACCGAACCCAACAAATGTTGATCAGCAAGTGCAATTTGGTACTTCTGGCCACCGTGGTACGGCAGATAAAG
CGACGTTTAACCAACATCATATTTGGGCGATAGCTCAAGCTGTGGCTGACGTACGTAAAGAAAATGGCGTAACGGGTCCA
TTATTTTTAGGTAAAGATACCCACGCGCTATCTGAACCTGCATTCACATCTGCTATTGAAGTACTTGTTGCTAATGGCGT
TGAAGTGATCATTCAAGAAAATAATGGCTACACACCAACTCCTGGTATCTCGCATGCAATCTTAACGCACAATGTTAAGT
GTGAAGATAAAGCGGATGGCATTGTGATAACTCCTTCTCATAACCCACCTCAAGATGGCGGTATTAAATATAATCCTGTT
CATGGTGGTCCTGCCGAGGGTGAGCTGACGACGGCAATTGAAAATCGTGCAAATCAATTAATTGCAAATGAATTAAAAGA
TGTTAAACGTGTATCAATTACTGAAGCGATGTCATCTGATTTAGTAAAGCAAATGGATTTAGTGCAGCCTTATATTGATG
ACTTAAAAAATGTTATTAATATTGAAGCGATTCAAAAAGCAAACCTAAAATTAGGTGTTGATCCATTAGGTGGTTCTGGT
ATTGAGTACTGGCGTCAAATTGGCCAAGCTTTTGATCTTGATTTAACGTTGGTGAGTGAAGCGATTGATCCTTCATTCCA
GTTTATGTCACTAGATAAAGATGGTGTAGTTCGAATGGACTGCTCGTCTCCTTATGCAATGGCTGGTCTATTATCATTAA
AAGATGAATATGACCTAGCGTTTGGTAATGATCCTGATTATGACCGTCATGGTATCGTAACGCCATCGGGCTTAATGAAT
CCAAATCACTACTTAGCGGTATGTATTGATTATCTATACCGTCATCGTCCAGAGTGGAAACCTGAAGTTGCTGTTGGTAA
AACATTAGTATCTTCTGCAATTATCGATAAAGTAGTTGCTGATCTTGGCCGTGATTTGTGTGAAGTGCCTGTAGGCTTTA
AGTGGTTTGTAGATGGCTTATATGCAGGCTCTTTAGGCTTTGGTGGTGAAGAAAGTGCAGGTGCTTCTTTCTTACGTTTT
GATGGTACGCCTTGGTCAACTGATAAAGATGGTATTCTTTTGTGTCTTCTTGCGGCTGAAATCACAGCTGTTACCGGTAT
GAATCCACAAGAATACTACAACAAACTGGCTGCTCAGCATGGCGAATCTAGCTACAATCGTATTCAAGCGGTTGCTAACA
AAGCGCAAAAAGCCGTGCTAAGTAAGTTATCACCAGAAATGGTTTCAGCAACAATGCTTGCTGGTGATGAGATCACTGCT
CGTTTAACACATGCTCCTGGTAACGGTGCAGCAATTGGTGGATTAAAAGTAACAACTGAAAATGGTTGGTTTGCTGCTCG
TCCATCAGGCACAGAAGAGATCTATAAGATTTACTGTGAAAGTTTTAAAGGTGCTGATCACTTAGCACTGATTGAACAAG
AAGCTCAAGAAATTGTAAGTAACGTGTTTAAAGAAGCCGGTTTATAA

Upstream 100 bases:

>100_bases
GCGAATGGGCTTCCAACATGATTTAACAGAAAAAGTGTGTGCGGCGATCTAATTTTTTGAGTCATAACTCAAATCATAAT
TTGTCACAAGGAATCGTCAA

Downstream 100 bases:

>100_bases
TTTTTTAAGTAATACAAATTAAGCAGCGCATGTCGCTGCTTTTTTTTGATAAGAAGGTCATGACATGAATAATTTTCAGT
TAGAACAATTATTAAACTCA

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAIHPRAGQKAQQEDLHNIPSLVANYFLLEPNPTNVDQQVQFGTSGHRGTADKATFNQHHIWAIAQAVADVRKENGVTGP
LFLGKDTHALSEPAFTSAIEVLVANGVEVIIQENNGYTPTPGISHAILTHNVKCEDKADGIVITPSHNPPQDGGIKYNPV
HGGPAEGELTTAIENRANQLIANELKDVKRVSITEAMSSDLVKQMDLVQPYIDDLKNVINIEAIQKANLKLGVDPLGGSG
IEYWRQIGQAFDLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLSLKDEYDLAFGNDPDYDRHGIVTPSGLMN
PNHYLAVCIDYLYRHRPEWKPEVAVGKTLVSSAIIDKVVADLGRDLCEVPVGFKWFVDGLYAGSLGFGGEESAGASFLRF
DGTPWSTDKDGILLCLLAAEITAVTGMNPQEYYNKLAAQHGESSYNRIQAVANKAQKAVLSKLSPEMVSATMLAGDEITA
RLTHAPGNGAAIGGLKVTTENGWFAARPSGTEEIYKIYCESFKGADHLALIEQEAQEIVSNVFKEAGL

Sequences:

>Translated_548_residues
MAIHPRAGQKAQQEDLHNIPSLVANYFLLEPNPTNVDQQVQFGTSGHRGTADKATFNQHHIWAIAQAVADVRKENGVTGP
LFLGKDTHALSEPAFTSAIEVLVANGVEVIIQENNGYTPTPGISHAILTHNVKCEDKADGIVITPSHNPPQDGGIKYNPV
HGGPAEGELTTAIENRANQLIANELKDVKRVSITEAMSSDLVKQMDLVQPYIDDLKNVINIEAIQKANLKLGVDPLGGSG
IEYWRQIGQAFDLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLSLKDEYDLAFGNDPDYDRHGIVTPSGLMN
PNHYLAVCIDYLYRHRPEWKPEVAVGKTLVSSAIIDKVVADLGRDLCEVPVGFKWFVDGLYAGSLGFGGEESAGASFLRF
DGTPWSTDKDGILLCLLAAEITAVTGMNPQEYYNKLAAQHGESSYNRIQAVANKAQKAVLSKLSPEMVSATMLAGDEITA
RLTHAPGNGAAIGGLKVTTENGWFAARPSGTEEIYKIYCESFKGADHLALIEQEAQEIVSNVFKEAGL
>Mature_547_residues
AIHPRAGQKAQQEDLHNIPSLVANYFLLEPNPTNVDQQVQFGTSGHRGTADKATFNQHHIWAIAQAVADVRKENGVTGPL
FLGKDTHALSEPAFTSAIEVLVANGVEVIIQENNGYTPTPGISHAILTHNVKCEDKADGIVITPSHNPPQDGGIKYNPVH
GGPAEGELTTAIENRANQLIANELKDVKRVSITEAMSSDLVKQMDLVQPYIDDLKNVINIEAIQKANLKLGVDPLGGSGI
EYWRQIGQAFDLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLSLKDEYDLAFGNDPDYDRHGIVTPSGLMNP
NHYLAVCIDYLYRHRPEWKPEVAVGKTLVSSAIIDKVVADLGRDLCEVPVGFKWFVDGLYAGSLGFGGEESAGASFLRFD
GTPWSTDKDGILLCLLAAEITAVTGMNPQEYYNKLAAQHGESSYNRIQAVANKAQKAVLSKLSPEMVSATMLAGDEITAR
LTHAPGNGAAIGGLKVTTENGWFAARPSGTEEIYKIYCESFKGADHLALIEQEAQEIVSNVFKEAGL

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI133922562, Length=408, Percent_Identity=25.2450980392157, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI290463102, Length=434, Percent_Identity=24.1935483870968, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI21361621, Length=443, Percent_Identity=23.9277652370203, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786904, Length=546, Percent_Identity=69.4139194139194, Blast_Score=793, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535441, Length=439, Percent_Identity=27.7904328018223, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323752, Length=574, Percent_Identity=25.7839721254355, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322722, Length=501, Percent_Identity=26.3473053892216, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17864244, Length=430, Percent_Identity=26.046511627907, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 59283; Mature: 59152

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHPRAGQKAQQEDLHNIPSLVANYFLLEPNPTNVDQQVQFGTSGHRGTADKATFNQHH
CCCCCCCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCHHEEECCCCCCCCCCCCCCCCHH
IWAIAQAVADVRKENGVTGPLFLGKDTHALSEPAFTSAIEVLVANGVEVIIQENNGYTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCC
PGISHAILTHNVKCEDKADGIVITPSHNPPQDGGIKYNPVHGGPAEGELTTAIENRANQL
CCCCCHHHCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
IANELKDVKRVSITEAMSSDLVKQMDLVQPYIDDLKNVINIEAIQKANLKLGVDPLGGSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCH
IEYWRQIGQAFDLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLSLKDEYDLA
HHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCEE
FGNDPDYDRHGIVTPSGLMNPNHYLAVCIDYLYRHRPEWKPEVAVGKTLVSSAIIDKVVA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DLGRDLCEVPVGFKWFVDGLYAGSLGFGGEESAGASFLRFDGTPWSTDKDGILLCLLAAE
HHCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHH
ITAVTGMNPQEYYNKLAAQHGESSYNRIQAVANKAQKAVLSKLSPEMVSATMLAGDEITA
HHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEE
RLTHAPGNGAAIGGLKVTTENGWFAARPSGTEEIYKIYCESFKGADHLALIEQEAQEIVS
EEEECCCCCEEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
NVFKEAGL
HHHHHCCC
>Mature Secondary Structure 
AIHPRAGQKAQQEDLHNIPSLVANYFLLEPNPTNVDQQVQFGTSGHRGTADKATFNQHH
CCCCCCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCHHEEECCCCCCCCCCCCCCCCHH
IWAIAQAVADVRKENGVTGPLFLGKDTHALSEPAFTSAIEVLVANGVEVIIQENNGYTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCC
PGISHAILTHNVKCEDKADGIVITPSHNPPQDGGIKYNPVHGGPAEGELTTAIENRANQL
CCCCCHHHCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
IANELKDVKRVSITEAMSSDLVKQMDLVQPYIDDLKNVINIEAIQKANLKLGVDPLGGSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCH
IEYWRQIGQAFDLDLTLVSEAIDPSFQFMSLDKDGVVRMDCSSPYAMAGLLSLKDEYDLA
HHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCEE
FGNDPDYDRHGIVTPSGLMNPNHYLAVCIDYLYRHRPEWKPEVAVGKTLVSSAIIDKVVA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DLGRDLCEVPVGFKWFVDGLYAGSLGFGGEESAGASFLRFDGTPWSTDKDGILLCLLAAE
HHCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHH
ITAVTGMNPQEYYNKLAAQHGESSYNRIQAVANKAQKAVLSKLSPEMVSATMLAGDEITA
HHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEE
RLTHAPGNGAAIGGLKVTTENGWFAARPSGTEEIYKIYCESFKGADHLALIEQEAQEIVS
EEEECCCCCEEECCEEEEECCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
NVFKEAGL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]