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The map label for this gene is hemH

Identifier: 59711401

GI number: 59711401

Start: 868530

End: 869498

Strand: Direct

Name: hemH

Synonym: VF_0794

Alternate gene names: 59711401

Gene position: 868530-869498 (Clockwise)

Preceding gene: 59711400

Following gene: 59711402

Centisome position: 29.97

GC content: 38.49

Gene sequence:

>969_bases
GTGAATAATAAAAAGACAGGGGTGTTGCTGGTTAATCTTGGAACACCAACAGCGCCAACAGCTGCTGCGGTAAAACAATT
TTTATCAGAATTTTTACATGATAAGCGAGTGGTGGATATGAATCGCTTCATATGGTGCCCATTGCTTCATGGTGTCATTC
TTCCTATACGCGCTCCGAAAGTTGCTAAGTTGTATGAAAGCGTTTGGATGGAAGAGGGATCTCCATTATTAGTGTATTCA
CAACGACAGGTAAAAGCATTAGAAGCACGCCTTTCTATGCCTGTAGCTTTAGGAATGACTTATGGTGAACCAAGAATTAA
ATCTGGTATTGAGTCATTAGAACAACAAGGCTGTGATGAGATAATTATTTTACCTTTGTATCCGCAATACTCTCGTACTA
CAACTGCAGCTGTTTTTGATCAAATTGCAAAACAATACAAAACGACACCTGTACTACCCAATTTCACCATGATTCATAAT
TACCATGATCACCCTTTGTACATTAAAGCACTTGCAAACTCCGTCCGTCAGTCGTGGGAACGGAATGGAAAGGGGGATTA
TGTTCTTTGCTCATACCACGGCATTCCACAACGTTTTGTTGATAATGGCGATATTTATGCAGCGCATTGTGAAAGAACAA
CCGAATTATTAGCACAAGAGCTAGGGTTAACTTCTGAACAAATTGGTATGAGTTATCAATCTCGTTTCGGGCGTGAAGAG
TGGTTAAAACCATACACTTCTGAAACATTAAAAGCGCTTGCGCCAAAAGGAATTAAATCACTAGACATTATTAGCCCTGC
TTTTTCGTCTGATTGCCTAGAGACGTTAGAAGAACTTTCTGAAGAGTGTAAAGAGATTTTCATGGAGTCTGGTGGTCAAA
AATACACCTTTATTCCGTGTTTAAATGATGATGAATTACACATTGAAATGATGGCAGATATTGTTAGTAGCAAAATTTTT
AATAAATAA

Upstream 100 bases:

>100_bases
AAAGCACTAGCGTAATCTTACGTAGTCAGTAATTTATTGCTATATTGAAGCGGCCTTTTATAGGTCGCTTTTTTTATGGA
AAATAAATAGGTAATTGACA

Downstream 100 bases:

>100_bases
CGGTTATTTTAAGAAAAAAATCGTTAATAAGGGTTGAAAAGTACTACTTATTCCCCAATTTCTCATTAAAGATTATCAAC
AAGTGTAGTGAGCCTCGACA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MNNKKTGVLLVNLGTPTAPTAAAVKQFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPKVAKLYESVWMEEGSPLLVYS
QRQVKALEARLSMPVALGMTYGEPRIKSGIESLEQQGCDEIIILPLYPQYSRTTTAAVFDQIAKQYKTTPVLPNFTMIHN
YHDHPLYIKALANSVRQSWERNGKGDYVLCSYHGIPQRFVDNGDIYAAHCERTTELLAQELGLTSEQIGMSYQSRFGREE
WLKPYTSETLKALAPKGIKSLDIISPAFSSDCLETLEELSEECKEIFMESGGQKYTFIPCLNDDELHIEMMADIVSSKIF
NK

Sequences:

>Translated_322_residues
MNNKKTGVLLVNLGTPTAPTAAAVKQFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPKVAKLYESVWMEEGSPLLVYS
QRQVKALEARLSMPVALGMTYGEPRIKSGIESLEQQGCDEIIILPLYPQYSRTTTAAVFDQIAKQYKTTPVLPNFTMIHN
YHDHPLYIKALANSVRQSWERNGKGDYVLCSYHGIPQRFVDNGDIYAAHCERTTELLAQELGLTSEQIGMSYQSRFGREE
WLKPYTSETLKALAPKGIKSLDIISPAFSSDCLETLEELSEECKEIFMESGGQKYTFIPCLNDDELHIEMMADIVSSKIF
NK
>Mature_322_residues
MNNKKTGVLLVNLGTPTAPTAAAVKQFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPKVAKLYESVWMEEGSPLLVYS
QRQVKALEARLSMPVALGMTYGEPRIKSGIESLEQQGCDEIIILPLYPQYSRTTTAAVFDQIAKQYKTTPVLPNFTMIHN
YHDHPLYIKALANSVRQSWERNGKGDYVLCSYHGIPQRFVDNGDIYAAHCERTTELLAQELGLTSEQIGMSYQSRFGREE
WLKPYTSETLKALAPKGIKSLDIISPAFSSDCLETLEELSEECKEIFMESGGQKYTFIPCLNDDELHIEMMADIVSSKIF
NK

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=26.8882175226586, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=26.8882175226586, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=53.4591194968553, Blast_Score=355, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6324750, Length=329, Percent_Identity=24.6200607902736, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=27.2727272727273, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=27.2030651340996, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=28.8235294117647, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_VIBF1 (Q5E6Q7)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204177.1
- ProteinModelPortal:   Q5E6Q7
- SMR:   Q5E6Q7
- STRING:   Q5E6Q7
- GeneID:   3278373
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0794
- NMPDR:   fig|312309.3.peg.567
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   GLPERHL
- PhylomeDB:   Q5E6Q7
- ProtClustDB:   PRK00035
- BioCyc:   VFIS312309:VF0794-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36406; Mature: 36406

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKKTGVLLVNLGTPTAPTAAAVKQFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPK
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHEECCCCCH
VAKLYESVWMEEGSPLLVYSQRQVKALEARLSMPVALGMTYGEPRIKSGIESLEQQGCDE
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCE
IIILPLYPQYSRTTTAAVFDQIAKQYKTTPVLPNFTMIHNYHDHPLYIKALANSVRQSWE
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
RNGKGDYVLCSYHGIPQRFVDNGDIYAAHCERTTELLAQELGLTSEQIGMSYQSRFGREE
HCCCCCEEEEEECCCCHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHCCHHHHHCCHHH
WLKPYTSETLKALAPKGIKSLDIISPAFSSDCLETLEELSEECKEIFMESGGQKYTFIPC
HCCCHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LNDDELHIEMMADIVSSKIFNK
CCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNKKTGVLLVNLGTPTAPTAAAVKQFLSEFLHDKRVVDMNRFIWCPLLHGVILPIRAPK
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHEECCCCCH
VAKLYESVWMEEGSPLLVYSQRQVKALEARLSMPVALGMTYGEPRIKSGIESLEQQGCDE
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCE
IIILPLYPQYSRTTTAAVFDQIAKQYKTTPVLPNFTMIHNYHDHPLYIKALANSVRQSWE
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
RNGKGDYVLCSYHGIPQRFVDNGDIYAAHCERTTELLAQELGLTSEQIGMSYQSRFGREE
HCCCCCEEEEEECCCCHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHCCHHHHHCCHHH
WLKPYTSETLKALAPKGIKSLDIISPAFSSDCLETLEELSEECKEIFMESGGQKYTFIPC
HCCCHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LNDDELHIEMMADIVSSKIFNK
CCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA