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The map label for this gene is adk [H]

Identifier: 59711400

GI number: 59711400

Start: 867800

End: 868444

Strand: Direct

Name: adk [H]

Synonym: VF_0793

Alternate gene names: 59711400

Gene position: 867800-868444 (Clockwise)

Preceding gene: 59711399

Following gene: 59711401

Centisome position: 29.95

GC content: 43.1

Gene sequence:

>645_bases
ATGCGTATCATCCTTTTAGGTGCACCAGGTGCGGGTAAAGGTACTCAAGCTCAGTTCATCATGGATAAATATGGTATTCC
ACAAATCTCTACAGGTGACATGCTACGTGCTGCAATCAAAGCTGGCACTGAGCTTGGTAAACAAGCAAAATCTGTAATTG
ATGCTGGTCAACTTGTATCTGATGAGATCATCCTTGGTCTTGTTAAAGAGCGTATTGCTCAAGAAGATTGCGCTAAAGGT
TTCCTACTAGATGGTTTCCCTCGTACAATTCCTCAAGCTGATGGCCTAAAAGAGAACGGTGTATCTATCGATTACGTTCT
TGAGTTTGACGTTGCTGACGAAGTTATCGTTGAGCGTATGTCTGGTCGTCGTGCTCACCTTCCTTCAGGTCGTACTTACC
ACGTAGTGTACAACCCACCAAAAGAAGAAGGTAAAGACGACGAAACTGGCGAACCTCTTGTTATCCGTGAAGATGATAAG
CCTGAGACAGTACTTGCTCGTTTAGGTATCTACCATGAGCAAACTGCACCGCTTATCGCTTACTACAACAAAGAAGCTGA
AGCAGGCAACACTAAGTACCTTAAATTTGATGGTACTAAATTAGTTGCTGAAGTAAGTGCTGAAATCGAAAAAGCACTAG
CGTAA

Upstream 100 bases:

>100_bases
TAGAAATAAAACTTATACCTAAGTTTATAAATATAGGTTAGGTAACTTTTATTTGTAAGGTTTGGTATAAATTCCAAGAT
TATTTTTTAAGGGGAAAACA

Downstream 100 bases:

>100_bases
TCTTACGTAGTCAGTAATTTATTGCTATATTGAAGCGGCCTTTTATAGGTCGCTTTTTTTATGGAAAATAAATAGGTAAT
TGACAGTGAATAATAAAAAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMDKYGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKG
FLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDK
PETVLARLGIYHEQTAPLIAYYNKEAEAGNTKYLKFDGTKLVAEVSAEIEKALA

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMDKYGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKG
FLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDK
PETVLARLGIYHEQTAPLIAYYNKEAEAGNTKYLKFDGTKLVAEVSAEIEKALA
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMDKYGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKG
FLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDK
PETVLARLGIYHEQTAPLIAYYNKEAEAGNTKYLKFDGTKLVAEVSAEIEKALA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=48.4042553191489, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=48.4042553191489, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=44.8648648648649, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=43.4065934065934, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=43.4065934065934, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=43.4065934065934, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=43.4065934065934, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=32.2404371584699, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=29.1208791208791, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=28.8770053475936, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144899, Length=187, Percent_Identity=28.8770053475936, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=31.1627906976744, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=26.6187050359712, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=74.6478873239437, Blast_Score=332, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=43.5779816513761, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=33.8028169014084, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=35.1648351648352, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=30.1075268817204, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=186, Percent_Identity=29.0322580645161, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=189, Percent_Identity=47.6190476190476, Blast_Score=191, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=43.298969072165, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=214, Percent_Identity=29.9065420560748, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=43.6018957345972, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17737899, Length=185, Percent_Identity=47.027027027027, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24645822, Length=185, Percent_Identity=47.027027027027, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=30.939226519337, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=30.939226519337, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=29.5774647887324, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=29.5774647887324, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23317; Mature: 23317

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMDKYGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVS
CEEEEEECCCCCCCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHH
SGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLARLGIYHEQTAPLIA
CCCEEECCCCCEEEEEECCCHHCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEE
YYNKEAEAGNTKYLKFDGTKLVAEVSAEIEKALA
EECCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMDKYGIPQISTGDMLRAAIKAGTELGKQAKSVIDAGQLVS
CEEEEEECCCCCCCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKENGVSIDYVLEFDVADEVIVERM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHH
SGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLARLGIYHEQTAPLIA
CCCEEECCCCCEEEEEECCCHHCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEE
YYNKEAEAGNTKYLKFDGTKLVAEVSAEIEKALA
EECCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA