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The map label for this gene is apaH

Identifier: 59710892

GI number: 59710892

Start: 289516

End: 290331

Strand: Reverse

Name: apaH

Synonym: VF_0285

Alternate gene names: 59710892

Gene position: 290331-289516 (Counterclockwise)

Preceding gene: 59710893

Following gene: 59710884

Centisome position: 10.02

GC content: 40.93

Gene sequence:

>816_bases
ATGGCAACTTACTTCGTTGGTGATATTCAAGGCTGTTTAGATGAACTGCTTTTATTATTAGAACGCGTTGAGTTTAATCG
AGAAAAAGATCAACTTTGGTTAACTGGAGATTTAGTTGCAAGAGGACCTAAATCATTAGAGACCTTGCGCTTTGTAAAAT
CATTAGGTAACGCTGCCGTCACTATCCTGGGTAACCATGATCTCCACCTACTTGCAGTATCTCAAGGCATTTCTCGCGTT
AAAGAAAAAGATAAAACCGCTCCTATTTTCACCGCGCCAGACAGTGAAGAACTGCTTACTTGGTTACGCCATCAACCATT
ACTAGCTGTTCATTCTGAATATGACATCGTAATGACTCACGCAGGCATTTCACCTCAATGGAATATGGCTACAGCAATAG
ACTGCGCCCGTGAAGTTGAATCTGTATTACTCTCTGATAAATGGGTTTTGCTATTAGAAAACATGTATGAAAACTACCCT
GATACATGGGATGTCACATTATCTGGCATAGATCGTTATCGCTATATCATTAATGCCTTTACTCGCATGCGTTTTTGCCA
CTTAGATGGACGCTTGGATATGGAATGCAAGCTACCTCCTCAAGATATTAATAGTGATGAGCTCGTACCTTGGTTTGAGT
TAGAAAATCGTCTTCCCCTTTCTCACAAAGTGATTTTTGGTCATTGGGCGGCATTGATGGGTCATGACGGAAATAACGTA
ATAGCACTCGATACAGGCTGTGTATGGGGGGAATATATGACGATGTATCGTGTTGATGATGGGAAGTATTTTACGCAGAA
GGCGATAGAACAGTAA

Upstream 100 bases:

>100_bases
GTTAGATGCAAATCATAGTGCAGAGTAAGCATTAACTGATTTCAATTGAGGTGACCTTATGGTCACCTTTTTTATATTTA
TCATATTTTGAGAGAATGGT

Downstream 100 bases:

>100_bases
CGAAAAGAAAGAAACGAAAAACGAGGACGCTACGCTCGAGGGACGAGGAAGAGTAGAAACTAGGAGCTATACGCTTCGCT
AGCTAGAAACTATAAGAACA

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MATYFVGDIQGCLDELLLLLERVEFNREKDQLWLTGDLVARGPKSLETLRFVKSLGNAAVTILGNHDLHLLAVSQGISRV
KEKDKTAPIFTAPDSEELLTWLRHQPLLAVHSEYDIVMTHAGISPQWNMATAIDCAREVESVLLSDKWVLLLENMYENYP
DTWDVTLSGIDRYRYIINAFTRMRFCHLDGRLDMECKLPPQDINSDELVPWFELENRLPLSHKVIFGHWAALMGHDGNNV
IALDTGCVWGEYMTMYRVDDGKYFTQKAIEQ

Sequences:

>Translated_271_residues
MATYFVGDIQGCLDELLLLLERVEFNREKDQLWLTGDLVARGPKSLETLRFVKSLGNAAVTILGNHDLHLLAVSQGISRV
KEKDKTAPIFTAPDSEELLTWLRHQPLLAVHSEYDIVMTHAGISPQWNMATAIDCAREVESVLLSDKWVLLLENMYENYP
DTWDVTLSGIDRYRYIINAFTRMRFCHLDGRLDMECKLPPQDINSDELVPWFELENRLPLSHKVIFGHWAALMGHDGNNV
IALDTGCVWGEYMTMYRVDDGKYFTQKAIEQ
>Mature_270_residues
ATYFVGDIQGCLDELLLLLERVEFNREKDQLWLTGDLVARGPKSLETLRFVKSLGNAAVTILGNHDLHLLAVSQGISRVK
EKDKTAPIFTAPDSEELLTWLRHQPLLAVHSEYDIVMTHAGISPQWNMATAIDCAREVESVLLSDKWVLLLENMYENYPD
TWDVTLSGIDRYRYIINAFTRMRFCHLDGRLDMECKLPPQDINSDELVPWFELENRLPLSHKVIFGHWAALMGHDGNNVI
ALDTGCVWGEYMTMYRVDDGKYFTQKAIEQ

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=269, Percent_Identity=52.7881040892193, Blast_Score=296, Evalue=8e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_VIBF1 (Q5E866)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_203668.1
- ProteinModelPortal:   Q5E866
- SMR:   Q5E866
- STRING:   Q5E866
- GeneID:   3277259
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0285
- NMPDR:   fig|312309.3.peg.285
- eggNOG:   COG0639
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- PhylomeDB:   Q5E866
- ProtClustDB:   PRK00166
- BioCyc:   VFIS312309:VF0285-MONOMER
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 31075; Mature: 30944

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATYFVGDIQGCLDELLLLLERVEFNREKDQLWLTGDLVARGPKSLETLRFVKSLGNAAV
CCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCEEE
TILGNHDLHLLAVSQGISRVKEKDKTAPIFTAPDSEELLTWLRHQPLLAVHSEYDIVMTH
EEEECCCEEEEEHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCEEEEECCCEEEEEE
AGISPQWNMATAIDCAREVESVLLSDKWVLLLENMYENYPDTWDVTLSGIDRYRYIINAF
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
TRMRFCHLDGRLDMECKLPPQDINSDELVPWFELENRLPLSHKVIFGHWAALMGHDGNNV
HHHHEEECCCCCCEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCE
IALDTGCVWGEYMTMYRVDDGKYFTQKAIEQ
EEEECCCCCCCEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
ATYFVGDIQGCLDELLLLLERVEFNREKDQLWLTGDLVARGPKSLETLRFVKSLGNAAV
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCEEE
TILGNHDLHLLAVSQGISRVKEKDKTAPIFTAPDSEELLTWLRHQPLLAVHSEYDIVMTH
EEEECCCEEEEEHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCEEEEECCCEEEEEE
AGISPQWNMATAIDCAREVESVLLSDKWVLLLENMYENYPDTWDVTLSGIDRYRYIINAF
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
TRMRFCHLDGRLDMECKLPPQDINSDELVPWFELENRLPLSHKVIFGHWAALMGHDGNNV
HHHHEEECCCCCCEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCE
IALDTGCVWGEYMTMYRVDDGKYFTQKAIEQ
EEEECCCCCCCEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA