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The map label for this gene is gmk

Identifier: 58617426

GI number: 58617426

Start: 1110291

End: 1110920

Strand: Reverse

Name: gmk

Synonym: ERGA_CDS_06990

Alternate gene names: 58617426

Gene position: 1110920-1110291 (Counterclockwise)

Preceding gene: 58617432

Following gene: 58617425

Centisome position: 74.07

GC content: 30.16

Gene sequence:

>630_bases
GTGAATAATAATCTAAAAAGCAGGGGAATAATGTTAGTTATGTCTTCTCCTTCTGGAGGGGGTAAAACTACTATATCGCA
GTTGTTGGTTAATGAATTACAGGGTGAGATTATTAGGTCAGTTTCTGTTACTACTCGTGAACCTAGAAATGAGGAAGTAG
AAGGTAAAGATTATTTTTTTGTTACTGAGGATGAATTTCATCATTTATGTAATACAAATCAAATGTTGGAATATGCTAAG
GTCTTTGGAAATTATTATGGTATTCCTCGTAGATTTGTAATGGATAATATAAATAATGGTATTAGCATATTGTTTAGTAT
AGATTGGCAAGGTGCATTTAAATTAATTGATATTATGAGTGAGCATGTGGTTAGTGTTTTTATATTACCTCCATCTATGG
AAGAGCTAAAAAGACGCCTATATAATAGAAGTGGTGAGAGTGATATGATTAACCAAAGATTAAAAGAAGCTGCTTTTGAG
ATCAGTCACTGTTATCGTTATAATTATATTATCGTTAATCATAATATTGAAGAAAGTGTACAACAAATAAAAAGTATTTT
TATTGCGGAGAAATTGAAAACACATCGTAAAATGTTTCTTGAGCAGGTTGTGAAGAGTTATTATATATAA

Upstream 100 bases:

>100_bases
AAGGTTAGCAATAGTTTTTTTTAAATAATTTATAGTCTGCTGTATTATTATATGAAATAACGTTGGTTATCTAAAAACAT
GTTTTATTGGGAAATATGCG

Downstream 100 bases:

>100_bases
TTGTGAAAATTGTAATATTATTTACTTATTGAAGTAAGATAAGTATTTTGTGGATTATTTATCATGTAATATAAATAGTT
ACTGTAGAATTTTTAAGGTA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNNNLKSRGIMLVMSSPSGGGKTTISQLLVNELQGEIIRSVSVTTREPRNEEVEGKDYFFVTEDEFHHLCNTNQMLEYAK
VFGNYYGIPRRFVMDNINNGISILFSIDWQGAFKLIDIMSEHVVSVFILPPSMEELKRRLYNRSGESDMINQRLKEAAFE
ISHCYRYNYIIVNHNIEESVQQIKSIFIAEKLKTHRKMFLEQVVKSYYI

Sequences:

>Translated_209_residues
MNNNLKSRGIMLVMSSPSGGGKTTISQLLVNELQGEIIRSVSVTTREPRNEEVEGKDYFFVTEDEFHHLCNTNQMLEYAK
VFGNYYGIPRRFVMDNINNGISILFSIDWQGAFKLIDIMSEHVVSVFILPPSMEELKRRLYNRSGESDMINQRLKEAAFE
ISHCYRYNYIIVNHNIEESVQQIKSIFIAEKLKTHRKMFLEQVVKSYYI
>Mature_209_residues
MNNNLKSRGIMLVMSSPSGGGKTTISQLLVNELQGEIIRSVSVTTREPRNEEVEGKDYFFVTEDEFHHLCNTNQMLEYAK
VFGNYYGIPRRFVMDNINNGISILFSIDWQGAFKLIDIMSEHVVSVFILPPSMEELKRRLYNRSGESDMINQRLKEAAFE
ISHCYRYNYIIVNHNIEESVQQIKSIFIAEKLKTHRKMFLEQVVKSYYI

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=30.7291666666667, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=30.7291666666667, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI226874831, Length=192, Percent_Identity=30.7291666666667, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1790080, Length=193, Percent_Identity=40.9326424870466, Blast_Score=154, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI193203132, Length=193, Percent_Identity=30.5699481865285, Blast_Score=93, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17508835, Length=193, Percent_Identity=30.5699481865285, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=37.7049180327869, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356141, Length=192, Percent_Identity=30.2083333333333, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_EHRRG (Q5FFZ9)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196625.1
- HSSP:   P60546
- ProteinModelPortal:   Q5FFZ9
- SMR:   Q5FFZ9
- STRING:   Q5FFZ9
- GeneID:   3268753
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_06990
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   ERUM302409:ERGA_CDS_06990-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24376; Mature: 24376

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNLKSRGIMLVMSSPSGGGKTTISQLLVNELQGEIIRSVSVTTREPRNEEVEGKDYFF
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VTEDEFHHLCNTNQMLEYAKVFGNYYGIPRRFVMDNINNGISILFSIDWQGAFKLIDIMS
EEHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHH
EHVVSVFILPPSMEELKRRLYNRSGESDMINQRLKEAAFEISHCYRYNYIIVNHNIEESV
HHHEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHH
QQIKSIFIAEKLKTHRKMFLEQVVKSYYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNNLKSRGIMLVMSSPSGGGKTTISQLLVNELQGEIIRSVSVTTREPRNEEVEGKDYFF
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VTEDEFHHLCNTNQMLEYAKVFGNYYGIPRRFVMDNINNGISILFSIDWQGAFKLIDIMS
EEHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHH
EHVVSVFILPPSMEELKRRLYNRSGESDMINQRLKEAAFEISHCYRYNYIIVNHNIEESV
HHHEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHH
QQIKSIFIAEKLKTHRKMFLEQVVKSYYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA