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The map label for this gene is pepA

Identifier: 58617387

GI number: 58617387

Start: 1039142

End: 1040644

Strand: Reverse

Name: pepA

Synonym: ERGA_CDS_06600

Alternate gene names: 58617387

Gene position: 1040644-1039142 (Counterclockwise)

Preceding gene: 58617389

Following gene: 58617386

Centisome position: 69.38

GC content: 34.4

Gene sequence:

>1503_bases
ATGATAAATGTATCATTTTTAGGTTTAATGTCTGGAATATCTGTATTATTAAAGACCACGGTAATAGTTGTAGGTATTTT
TGAAGGAAGTAATCATTTAGAGGATAATGGTGCTTTAGAAGGTTATAATGATAAAATCATGGAAATAGTAAATGGTTATC
AATCTTTTGATGGTAAGTTTGCTGAGGTATTACCTATTATTGGGTTAGAGAAAGATTTTCCTGTTGTGGTAGTTATTGGA
CTGGGTAAATCTGAGGATTTTGATGAAAATAAAGCTTTAAAAGTTGGTGGTGTAATATATTCTGAACTTAATAGAATGAA
AGTACCAGATGCATCAATTGTTATTAATACTGATAGTAATGTAAGTGCTAATATTGGTTATGGAGCACTTTTACGTAGTT
TTAAATTTGATAAATATTTCGTAGAGAAAAAAGATAAAAATTCAGTTTATTTGAATAAGTTGGTTCTATTCTCAAAGAAT
GATCCACAAGAGGTTACTGCTTTGTTTAATGATTTAAAAGCTGAAGGTGAGTCAATATTCTTAGCTCGTTCTTTTGTTTC
AGAACCTCCGAATATTTTATATCCAGAAACGTATGCTCAGATGATATATGAAGAATTAAGTAAGGTTGGTGTAACAGTTG
AAGTCTTTGATGAAGATTACATGAAAGCAAATCAAATGATGGCACTTCTTGGAGTAGGTCAGGGTAGTGCTAAAAAATCT
CGACTTGTAGTTATGAAATGGAATGGAGGTGATGAATCAGAAAGTCCTATTGCGTTTGTTGGAAAAGGTGTAACTTTTGA
TACTGGTGGAATATCCTTAAAACCTTCAAAGGGTATGTGGGATATGAAATATGATATGGCAGGTTCTGCTTCTGTTGTTG
GAATTATGCGTACTCTTGCTGCAAGGAAGGCAAAAGTTAATGCTGTTGGAGTAGTTGGATTAGTTGAAAATTCAGTGGAT
GGGAATGCGCAAAGACCTAGTGATGTTGTTATTTCAATGTCTGGACAAACAATTGAGGTGTTAAATACTGATGCAGAGGG
GAGGTTGGTTTTAGCTGATGCGTTATGGTATACTCAAGAGATGTTTACTCCTAAATTAATGGTGGATTTAGCAACATTAA
CTGGTGCAGTAGTGGTTGCTTTAGGTAATAATCAGTATGCTGGGCTTTTTTCAAATGATGATGCTATTGCAAATCAGTTG
ATTGTAGCTGGGAATGAATCTGGTGAAAAATTATGGCGGTTACCTTTAGATGAAGCCTATGATAAACTTATAGATTCATC
AATTGCTGATATGCAGAATATTTCAACAAAAGGATATGGGGCTGATAGTATTACTGCAGCACAGTTCTTACAAAGATTTG
TTAATGGTGTTCCTTGGGTGCATTTGGATATTGCTGGTATGGCATGGGATTATGAAGGCACTGAGATATGTCCTAAGGGT
GCAACTGGTTTTGGGGTAAGGCTATTAAATAGATTTGTATCAAAGTACTACGAGTCTCATTAG

Upstream 100 bases:

>100_bases
ATCAAGGTTAGGTAATCAAGTGAGTTAAAATTTTCCTTGAAAAGCTTTGAAAAAAGACTAGAGTAAACATATAGTTGAAT
TATACCAATGAAGGGTAGTC

Downstream 100 bases:

>100_bases
TTGTTTCTTCTTCATTTATAGTTTAAGTAAAGTAATGTATCTTGATTTCTATGTTACTCAATTTAAGTTTATATAGTAGG
CTGATTTTTTGGTATTGTGA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MINVSFLGLMSGISVLLKTTVIVVGIFEGSNHLEDNGALEGYNDKIMEIVNGYQSFDGKFAEVLPIIGLEKDFPVVVVIG
LGKSEDFDENKALKVGGVIYSELNRMKVPDASIVINTDSNVSANIGYGALLRSFKFDKYFVEKKDKNSVYLNKLVLFSKN
DPQEVTALFNDLKAEGESIFLARSFVSEPPNILYPETYAQMIYEELSKVGVTVEVFDEDYMKANQMMALLGVGQGSAKKS
RLVVMKWNGGDESESPIAFVGKGVTFDTGGISLKPSKGMWDMKYDMAGSASVVGIMRTLAARKAKVNAVGVVGLVENSVD
GNAQRPSDVVISMSGQTIEVLNTDAEGRLVLADALWYTQEMFTPKLMVDLATLTGAVVVALGNNQYAGLFSNDDAIANQL
IVAGNESGEKLWRLPLDEAYDKLIDSSIADMQNISTKGYGADSITAAQFLQRFVNGVPWVHLDIAGMAWDYEGTEICPKG
ATGFGVRLLNRFVSKYYESH

Sequences:

>Translated_500_residues
MINVSFLGLMSGISVLLKTTVIVVGIFEGSNHLEDNGALEGYNDKIMEIVNGYQSFDGKFAEVLPIIGLEKDFPVVVVIG
LGKSEDFDENKALKVGGVIYSELNRMKVPDASIVINTDSNVSANIGYGALLRSFKFDKYFVEKKDKNSVYLNKLVLFSKN
DPQEVTALFNDLKAEGESIFLARSFVSEPPNILYPETYAQMIYEELSKVGVTVEVFDEDYMKANQMMALLGVGQGSAKKS
RLVVMKWNGGDESESPIAFVGKGVTFDTGGISLKPSKGMWDMKYDMAGSASVVGIMRTLAARKAKVNAVGVVGLVENSVD
GNAQRPSDVVISMSGQTIEVLNTDAEGRLVLADALWYTQEMFTPKLMVDLATLTGAVVVALGNNQYAGLFSNDDAIANQL
IVAGNESGEKLWRLPLDEAYDKLIDSSIADMQNISTKGYGADSITAAQFLQRFVNGVPWVHLDIAGMAWDYEGTEICPKG
ATGFGVRLLNRFVSKYYESH
>Mature_500_residues
MINVSFLGLMSGISVLLKTTVIVVGIFEGSNHLEDNGALEGYNDKIMEIVNGYQSFDGKFAEVLPIIGLEKDFPVVVVIG
LGKSEDFDENKALKVGGVIYSELNRMKVPDASIVINTDSNVSANIGYGALLRSFKFDKYFVEKKDKNSVYLNKLVLFSKN
DPQEVTALFNDLKAEGESIFLARSFVSEPPNILYPETYAQMIYEELSKVGVTVEVFDEDYMKANQMMALLGVGQGSAKKS
RLVVMKWNGGDESESPIAFVGKGVTFDTGGISLKPSKGMWDMKYDMAGSASVVGIMRTLAARKAKVNAVGVVGLVENSVD
GNAQRPSDVVISMSGQTIEVLNTDAEGRLVLADALWYTQEMFTPKLMVDLATLTGAVVVALGNNQYAGLFSNDDAIANQL
IVAGNESGEKLWRLPLDEAYDKLIDSSIADMQNISTKGYGADSITAAQFLQRFVNGVPWVHLDIAGMAWDYEGTEICPKG
ATGFGVRLLNRFVSKYYESH

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=485, Percent_Identity=33.1958762886598, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI47155554, Length=369, Percent_Identity=32.520325203252, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790710, Length=503, Percent_Identity=37.5745526838966, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=35.423197492163, Blast_Score=181, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=333, Percent_Identity=33.9339339339339, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=358, Percent_Identity=29.3296089385475, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355725, Length=448, Percent_Identity=32.5892857142857, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24661038, Length=445, Percent_Identity=32.8089887640449, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129969, Length=462, Percent_Identity=29.8701298701299, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24662227, Length=340, Percent_Identity=33.2352941176471, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161077148, Length=434, Percent_Identity=29.0322580645161, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20130057, Length=434, Percent_Identity=29.0322580645161, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI19922386, Length=461, Percent_Identity=29.5010845986985, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129963, Length=419, Percent_Identity=30.5489260143198, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21355645, Length=341, Percent_Identity=31.9648093841642, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24662223, Length=341, Percent_Identity=31.9648093841642, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21357381, Length=346, Percent_Identity=32.0809248554913, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221379063, Length=346, Percent_Identity=32.0809248554913, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221379062, Length=346, Percent_Identity=32.0809248554913, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646701, Length=258, Percent_Identity=26.7441860465116, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24646703, Length=258, Percent_Identity=26.7441860465116, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21358201, Length=258, Percent_Identity=26.7441860465116, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_EHRRG (Q5FFZ5)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196586.1
- HSSP:   P68767
- ProteinModelPortal:   Q5FFZ5
- SMR:   Q5FFZ5
- STRING:   Q5FFZ5
- MEROPS:   M17.003
- GeneID:   3268656
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_06600
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   NMHLMRY
- ProtClustDB:   PRK00913
- BioCyc:   ERUM302409:ERGA_CDS_06600-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54436; Mature: 54436

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 274-274 ACT_SITE 348-348

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVSFLGLMSGISVLLKTTVIVVGIFEGSNHLEDNGALEGYNDKIMEIVNGYQSFDGKF
CEEEHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCH
AEVLPIIGLEKDFPVVVVIGLGKSEDFDENKALKVGGVIYSELNRMKVPDASIVINTDSN
HHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEECHHHHHHHHCCCCCCCEEEEECCCC
VSANIGYGALLRSFKFDKYFVEKKDKNSVYLNKLVLFSKNDPQEVTALFNDLKAEGESIF
CEECCCHHHHHHHHCCCHHEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
LARSFVSEPPNILYPETYAQMIYEELSKVGVTVEVFDEDYMKANQMMALLGVGQGSAKKS
EEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHEEEEEECCCCCCCCC
RLVVMKWNGGDESESPIAFVGKGVTFDTGGISLKPSKGMWDMKYDMAGSASVVGIMRTLA
EEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCCCEEEECCCCCHHHHHHHHHHH
ARKAKVNAVGVVGLVENSVDGNAQRPSDVVISMSGQTIEVLNTDAEGRLVLADALWYTQE
HHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCCCEEEEHHHHHHHH
MFTPKLMVDLATLTGAVVVALGNNQYAGLFSNDDAIANQLIVAGNESGEKLWRLPLDEAY
HCCHHHHHHHHHHCCEEEEEECCCEEEEEECCCHHHHCEEEEECCCCCCEEEECCHHHHH
DKLIDSSIADMQNISTKGYGADSITAAQFLQRFVNGVPWVHLDIAGMAWDYEGTEICPKG
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEECCCC
ATGFGVRLLNRFVSKYYESH
CCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINVSFLGLMSGISVLLKTTVIVVGIFEGSNHLEDNGALEGYNDKIMEIVNGYQSFDGKF
CEEEHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCH
AEVLPIIGLEKDFPVVVVIGLGKSEDFDENKALKVGGVIYSELNRMKVPDASIVINTDSN
HHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEECHHHHHHHHCCCCCCCEEEEECCCC
VSANIGYGALLRSFKFDKYFVEKKDKNSVYLNKLVLFSKNDPQEVTALFNDLKAEGESIF
CEECCCHHHHHHHHCCCHHEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
LARSFVSEPPNILYPETYAQMIYEELSKVGVTVEVFDEDYMKANQMMALLGVGQGSAKKS
EEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHEEEEEECCCCCCCCC
RLVVMKWNGGDESESPIAFVGKGVTFDTGGISLKPSKGMWDMKYDMAGSASVVGIMRTLA
EEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCCCEEEECCCCCHHHHHHHHHHH
ARKAKVNAVGVVGLVENSVDGNAQRPSDVVISMSGQTIEVLNTDAEGRLVLADALWYTQE
HHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCCCEEEEHHHHHHHH
MFTPKLMVDLATLTGAVVVALGNNQYAGLFSNDDAIANQLIVAGNESGEKLWRLPLDEAY
HCCHHHHHHHHHHCCEEEEEECCCEEEEEECCCHHHHCEEEEECCCCCCEEEECCHHHHH
DKLIDSSIADMQNISTKGYGADSITAAQFLQRFVNGVPWVHLDIAGMAWDYEGTEICPKG
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEECCCC
ATGFGVRLLNRFVSKYYESH
CCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA