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The map label for this gene is tsaA [H]

Identifier: 58617078

GI number: 58617078

Start: 579288

End: 579905

Strand: Reverse

Name: tsaA [H]

Synonym: ERGA_CDS_03510

Alternate gene names: 58617078

Gene position: 579905-579288 (Counterclockwise)

Preceding gene: 58617080

Following gene: 58617077

Centisome position: 38.66

GC content: 32.04

Gene sequence:

>618_bases
ATGAATCTCATCACAAAACAAGCTATTGATTTCACAGCAAAAGCTGTAATGCCAGATGATAAAATTTGCGAATTCAATTT
AAAGCAATACATTAGTGGCAAGTATGCTATCTTAGTTTTTTACCCACGAGACTTTACTTTTGTATGCCCTACAGAAATCA
TATCCTTACATAACAGAATACCACAATTTATAGAGAAAAATACTGAAATTATAGGAATCAGTACAGATTCAGAGTTTTGT
CATAGTCATTGGCGTAACATTAGTGTAAATAAAGGTGGAATTGATAAAATTAGCTTTCCATTGATCGCAGATGACTCACA
TTCAATATCTAATAATTACGGGGTGTTATACAATAACAGCATTGCACTAAGAGCAACATTTATTATAGATGACCACTTTA
TTGTAAGACATCAATCAATTAATGATTTACCTATTGGAAGAAATGTAGACGAATTGCTAAGAATTATAGATGCAATAAAA
CATCACCAAATACATGGAGAAGTATGTCCTGCTGGATGGATAAAGGGAGATCCAGCAATGGAAGCTTCTCAACATGGCAT
CGAGGACTATTTAAAATCACATATAGATAATCTTGAAAAAAGTATTATGGACAAATAA

Upstream 100 bases:

>100_bases
CTTAATTGTAAAAATATAATAAAATATAATTACAAAACTATTTAATTGTAGTATTTAGTATTTTATGATCATTGCTCATT
TTAACTAACTAGGTAATTCT

Downstream 100 bases:

>100_bases
ATGACACAAATATATAAAACTCAAGTTTTAATTTTAGGATCTGGAGCAGCAGGATGTACTGCTGCTATATATGCTGCGCG
TGCAAATTTACAACCCATAT

Product: putative peroxiredoxin (26 kDa antigen)

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MNLITKQAIDFTAKAVMPDDKICEFNLKQYISGKYAILVFYPRDFTFVCPTEIISLHNRIPQFIEKNTEIIGISTDSEFC
HSHWRNISVNKGGIDKISFPLIADDSHSISNNYGVLYNNSIALRATFIIDDHFIVRHQSINDLPIGRNVDELLRIIDAIK
HHQIHGEVCPAGWIKGDPAMEASQHGIEDYLKSHIDNLEKSIMDK

Sequences:

>Translated_205_residues
MNLITKQAIDFTAKAVMPDDKICEFNLKQYISGKYAILVFYPRDFTFVCPTEIISLHNRIPQFIEKNTEIIGISTDSEFC
HSHWRNISVNKGGIDKISFPLIADDSHSISNNYGVLYNNSIALRATFIIDDHFIVRHQSINDLPIGRNVDELLRIIDAIK
HHQIHGEVCPAGWIKGDPAMEASQHGIEDYLKSHIDNLEKSIMDK
>Mature_205_residues
MNLITKQAIDFTAKAVMPDDKICEFNLKQYISGKYAILVFYPRDFTFVCPTEIISLHNRIPQFIEKNTEIIGISTDSEFC
HSHWRNISVNKGGIDKISFPLIADDSHSISNNYGVLYNNSIALRATFIIDDHFIVRHQSINDLPIGRNVDELLRIIDAIK
HHQIHGEVCPAGWIKGDPAMEASQHGIEDYLKSHIDNLEKSIMDK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=188, Percent_Identity=43.6170212765958, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI32455266, Length=188, Percent_Identity=43.6170212765958, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI32455264, Length=188, Percent_Identity=43.6170212765958, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI32189392, Length=192, Percent_Identity=44.2708333333333, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI5453549, Length=183, Percent_Identity=46.448087431694, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI5802974, Length=190, Percent_Identity=39.4736842105263, Blast_Score=158, Evalue=3e-39,
Organism=Homo sapiens, GI32483377, Length=189, Percent_Identity=39.6825396825397, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI33188454, Length=81, Percent_Identity=50.6172839506173, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4758638, Length=161, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786822, Length=153, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI32565831, Length=193, Percent_Identity=44.0414507772021, Blast_Score=166, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI193204376, Length=193, Percent_Identity=44.0414507772021, Blast_Score=166, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17554494, Length=164, Percent_Identity=40.8536585365854, Blast_Score=142, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI25153706, Length=163, Percent_Identity=26.9938650306748, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=191, Percent_Identity=41.3612565445026, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320661, Length=191, Percent_Identity=38.7434554973822, Blast_Score=145, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319407, Length=168, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24656348, Length=175, Percent_Identity=47.4285714285714, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI17864676, Length=175, Percent_Identity=47.4285714285714, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI17738015, Length=171, Percent_Identity=48.5380116959064, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17157991, Length=194, Percent_Identity=41.2371134020619, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24641739, Length=194, Percent_Identity=41.2371134020619, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21357347, Length=193, Percent_Identity=40.4145077720207, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24581278, Length=177, Percent_Identity=29.9435028248588, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17975518, Length=163, Percent_Identity=28.8343558282209, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24652436, Length=163, Percent_Identity=28.8343558282209, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24652434, Length=163, Percent_Identity=28.8343558282209, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 23349; Mature: 23349

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLITKQAIDFTAKAVMPDDKICEFNLKQYISGKYAILVFYPRDFTFVCPTEIISLHNRI
CCCCHHHHHHHHHHCCCCCCCCEEECHHHHCCCCEEEEEEECCCCEEECHHHHHHHHHHH
PQFIEKNTEIIGISTDSEFCHSHWRNISVNKGGIDKISFPLIADDSHSISNNYGVLYNNS
HHHHHCCCEEEEEECCHHHHHHHCCEECCCCCCCCEEECEEEECCCCCCCCCCCEEECCC
IALRATFIIDDHFIVRHQSINDLPIGRNVDELLRIIDAIKHHQIHGEVCPAGWIKGDPAM
EEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EASQHGIEDYLKSHIDNLEKSIMDK
HHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLITKQAIDFTAKAVMPDDKICEFNLKQYISGKYAILVFYPRDFTFVCPTEIISLHNRI
CCCCHHHHHHHHHHCCCCCCCCEEECHHHHCCCCEEEEEEECCCCEEECHHHHHHHHHHH
PQFIEKNTEIIGISTDSEFCHSHWRNISVNKGGIDKISFPLIADDSHSISNNYGVLYNNS
HHHHHCCCEEEEEECCHHHHHHHCCEECCCCCCCCEEECEEEECCCCCCCCCCCEEECCC
IALRATFIIDDHFIVRHQSINDLPIGRNVDELLRIIDAIKHHQIHGEVCPAGWIKGDPAM
EEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EASQHGIEDYLKSHIDNLEKSIMDK
HHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]