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The map label for this gene is virB11 [H]

Identifier: 58616741

GI number: 58616741

Start: 14613

End: 15611

Strand: Reverse

Name: virB11 [H]

Synonym: ERGA_CDS_00140

Alternate gene names: 58616741

Gene position: 15611-14613 (Counterclockwise)

Preceding gene: 58616742

Following gene: 58616740

Centisome position: 1.04

GC content: 33.83

Gene sequence:

>999_bases
ATGACAACAAGTTATGCAGCTTTAAATACATATCTTGAACCATTACAGGCTATCTTTCAGGAAGAAGGAGTAAATGAAAT
ATCTATAAACCAAGAGTGTGAGGTGTGGATAGAAAATCGAGGAAATATACGTTGTGAATCTATACCAGTTCTCAATCTAT
CACACCTAAAAGCATTAGGAAGATTAATTGCCCAGGCTACAGAACAAAAAATAAGTGAGGAAAATCCCCTATTATCAGCA
ACATTACCTAATGGCTATCGTATACAGATAGTTTTTCCTCCAGCATGTGAAGCAACTGCAGTTGCTATGTCAATAAGGAA
ACCATCAGCTATGCAGCTTTCCTTAGATGACTATGAAAAAATGGGAGCATTTGACCAAGCCATAACAGAAAATCAACAGA
ATACCGTAGATATTGAACTCAATAAATTATTAAAACAAAAAAAAATCAAAGACTTTTTAGAGTATGCAATATTACATAAG
AAAAACATAATAATAAGTGGTGGTACATCAACGGGAAAAACAACTTTTACTAATGCGGCATTACGTACCATACCAAAGGA
TGAAAGGTTAATTACAGTAGAGGATGCAAGAGAAATTGTTTTAAATAATCATCCAAATCGAGTACATCTTATAACATCCA
AAGGAGGGCAAGGTAGAGCTAAAGTAAGTATTCAAGATCTAATAGAAGCATGCTTAAGGTTACGTCCAGATAGAATAATA
GTTGGAGAGCTACGTGGAGCAGAAGCTTTTAGTTTCCTAAGAGCAATTAATACAGGACACCCTGGATCAATATCTACTCT
ACATGCTGATACACCAATGATGGCTCTTGAACAATTAAAACTTATGGTTATGCAAGCAGGTCTTGGTATTCCTCCTGATC
AAATTATCAATTATATAACCAATATAGTTGATATTGTAATACAATTAAAACGTGGATCATCTGGTGTAAGATATGTATCA
GAAATACTGTTCACTAAATCTTTACAGAAAAATGATTAA

Upstream 100 bases:

>100_bases
CTCTACTAAAAGTGTTTGTTAATAAAGATATTGTGTTTCCCAAAGAAGCAGTACGTGGAATAAATGTAGTAAATTAATAT
AGTTTTTTTAGAAGGTTTAT

Downstream 100 bases:

>100_bases
ATTAAATAAACAAATTTTATATATGTAAGTTATTAGTGTTATGGATAGTACAAGCGCAAATCATATTCGCAATATTTTAT
TTCTATTTCTAGGTGCATTC

Product: type IV secretion system ATPase VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTTSYAALNTYLEPLQAIFQEEGVNEISINQECEVWIENRGNIRCESIPVLNLSHLKALGRLIAQATEQKISEENPLLSA
TLPNGYRIQIVFPPACEATAVAMSIRKPSAMQLSLDDYEKMGAFDQAITENQQNTVDIELNKLLKQKKIKDFLEYAILHK
KNIIISGGTSTGKTTFTNAALRTIPKDERLITVEDAREIVLNNHPNRVHLITSKGGQGRAKVSIQDLIEACLRLRPDRII
VGELRGAEAFSFLRAINTGHPGSISTLHADTPMMALEQLKLMVMQAGLGIPPDQIINYITNIVDIVIQLKRGSSGVRYVS
EILFTKSLQKND

Sequences:

>Translated_332_residues
MTTSYAALNTYLEPLQAIFQEEGVNEISINQECEVWIENRGNIRCESIPVLNLSHLKALGRLIAQATEQKISEENPLLSA
TLPNGYRIQIVFPPACEATAVAMSIRKPSAMQLSLDDYEKMGAFDQAITENQQNTVDIELNKLLKQKKIKDFLEYAILHK
KNIIISGGTSTGKTTFTNAALRTIPKDERLITVEDAREIVLNNHPNRVHLITSKGGQGRAKVSIQDLIEACLRLRPDRII
VGELRGAEAFSFLRAINTGHPGSISTLHADTPMMALEQLKLMVMQAGLGIPPDQIINYITNIVDIVIQLKRGSSGVRYVS
EILFTKSLQKND
>Mature_331_residues
TTSYAALNTYLEPLQAIFQEEGVNEISINQECEVWIENRGNIRCESIPVLNLSHLKALGRLIAQATEQKISEENPLLSAT
LPNGYRIQIVFPPACEATAVAMSIRKPSAMQLSLDDYEKMGAFDQAITENQQNTVDIELNKLLKQKKIKDFLEYAILHKK
NIIISGGTSTGKTTFTNAALRTIPKDERLITVEDAREIVLNNHPNRVHLITSKGGQGRAKVSIQDLIEACLRLRPDRIIV
GELRGAEAFSFLRAINTGHPGSISTLHADTPMMALEQLKLMVMQAGLGIPPDQIINYITNIVDIVIQLKRGSSGVRYVSE
ILFTKSLQKND

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36860; Mature: 36729

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSYAALNTYLEPLQAIFQEEGVNEISINQECEVWIENRGNIRCESIPVLNLSHLKALG
CCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCEEECCCCCCCHHHHHHHH
RLIAQATEQKISEENPLLSATLPNGYRIQIVFPPACEATAVAMSIRKPSAMQLSLDDYEK
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCHHHHHHCCCCCCCEEEEHHHHHH
MGAFDQAITENQQNTVDIELNKLLKQKKIKDFLEYAILHKKNIIISGGTSTGKTTFTNAA
HCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEHHHHH
LRTIPKDERLITVEDAREIVLNNHPNRVHLITSKGGQGRAKVSIQDLIEACLRLRPDRII
HHCCCCCCCEEECCCHHHHHCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHCCCCEEE
VGELRGAEAFSFLRAINTGHPGSISTLHADTPMMALEQLKLMVMQAGLGIPPDQIINYIT
EEECCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
NIVDIVIQLKRGSSGVRYVSEILFTKSLQKND
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTSYAALNTYLEPLQAIFQEEGVNEISINQECEVWIENRGNIRCESIPVLNLSHLKALG
CCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCEEECCCCCCCHHHHHHHH
RLIAQATEQKISEENPLLSATLPNGYRIQIVFPPACEATAVAMSIRKPSAMQLSLDDYEK
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCHHHHHHCCCCCCCEEEEHHHHHH
MGAFDQAITENQQNTVDIELNKLLKQKKIKDFLEYAILHKKNIIISGGTSTGKTTFTNAA
HCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEHHHHH
LRTIPKDERLITVEDAREIVLNNHPNRVHLITSKGGQGRAKVSIQDLIEACLRLRPDRII
HHCCCCCCCEEECCCHHHHHCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHCCCCEEE
VGELRGAEAFSFLRAINTGHPGSISTLHADTPMMALEQLKLMVMQAGLGIPPDQIINYIT
EEECCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
NIVDIVIQLKRGSSGVRYVSEILFTKSLQKND
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]