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The map label for this gene is virB10 [H]

Identifier: 58616742

GI number: 58616742

Start: 15635

End: 16975

Strand: Reverse

Name: virB10 [H]

Synonym: ERGA_CDS_00150

Alternate gene names: 58616742

Gene position: 16975-15635 (Counterclockwise)

Preceding gene: 58616743

Following gene: 58616741

Centisome position: 1.13

GC content: 33.04

Gene sequence:

>1341_bases
ATGTCAGAAGAAAATTACAATAACCACAATAACATAGAACTTGAAGAAAGTGTCAATGTTGTAGGAACACATAAAGGAAA
AAAAGCTATAATAGTAGGAGCACTTGTAGTTGTATTAGGATTAACCTATTACTTTTTCTTCAACAACAAAAAAACAGATG
ATTCAACAACTACATCAAAATCATCACAAGAAGTAGACATAGAAAAATTATTAAAAGATTCTGTACCACCAGCTCAAGAG
GTTTCTCCCATGGTAAATATTCCACCTCAATTACCAGAGTTACCTCCATTAGTATCACCATCTTTACCATCACTACCAAC
TATTGAAAAACCTAAAGTATTAGAAGTACCAAAAATTGTACAAAAAGAAAAAAAAATACCAGCACCTTTACCAACCGTTG
AAACTAAATCAGAACCAGAAGTTAAGATACCCCTACCTACTCAAAATAATGTAGAAGTAGTTACACCTATTGCACCAACA
ACAACAGGATATGATAAAGAGAGAAGAACAACATCCATGCTTACCATATCAGGAGGGCAGGATTTAACAGCTGGACAAAA
CAATGAAGAAGGTACTGATCCTAATAACAAAATTGGTAATTTTGTAGATTCAGTAATGTCATTCAAACCTACATCGTCTC
CTAATGTAGTAGCAACAAAAATTAACAATTTAGAATTAACAATCTTACAAGGTAAGATAATTGATGTAGTTTTAGAAACT
GCAATTAATTCTGACCTACAAGGTACATTAAGAGGCATAGTAGCACGTGATGTTTATTCAGAAGCTGGTAACGTAGTTAT
GATACCAAAAGGATCAAGACTTATAGGTAATTATTCTTTCAATGCCAGCCCAGGAAAAACTAGAGTTCAAATATCCTGGA
ACAGAGTAATTCTACCTCACGGCGTAGATATAGCACTTGATTCTACTGGAACAGATGAACTAGGAAGACAAGGAGCATCA
GGGGTTGTTGATACCAAAGTTGGCAGCATATTAACCTCCACTATACTACTTGCAGGTGTATCGATAGCAACATCATATGT
AACTTCAAAAATTCCTGAAATAAATGATCATCCAATTATAGAGTCAAAGTCTGACGATAAAGATAAAGATAAAGACAAAG
ATAAGGATAAGGATAAAGATAAAACAAAAACCACATTACCTGTAAAAATTCTATCTAAAGCAGTAGATGATTTTTCACAG
TCTATAAAGGACATTATACAAAAGTATACAAACAATAATCCAACAGTATATGTGGACCAAGGTACTCTACTAAAAGTGTT
TGTTAATAAAGATATTGTGTTTCCCAAAGAAGCAGTACGTGGAATAAATGTAGTAAATTAA

Upstream 100 bases:

>100_bases
TAATAATAAAGGGTGTACATAAAAATTTATATATTCAATATAAGAATGAATTCATAAACATTACTAACAAGCATTTATAA
TAAAACTCATATGGTACACT

Downstream 100 bases:

>100_bases
TATAGTTTTTTTAGAAGGTTTATATGACAACAAGTTATGCAGCTTTAAATACATATCTTGAACCATTACAGGCTATCTTT
CAGGAAGAAGGAGTAAATGA

Product: VirB10 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSEENYNNHNNIELEESVNVVGTHKGKKAIIVGALVVVLGLTYYFFFNNKKTDDSTTTSKSSQEVDIEKLLKDSVPPAQE
VSPMVNIPPQLPELPPLVSPSLPSLPTIEKPKVLEVPKIVQKEKKIPAPLPTVETKSEPEVKIPLPTQNNVEVVTPIAPT
TTGYDKERRTTSMLTISGGQDLTAGQNNEEGTDPNNKIGNFVDSVMSFKPTSSPNVVATKINNLELTILQGKIIDVVLET
AINSDLQGTLRGIVARDVYSEAGNVVMIPKGSRLIGNYSFNASPGKTRVQISWNRVILPHGVDIALDSTGTDELGRQGAS
GVVDTKVGSILTSTILLAGVSIATSYVTSKIPEINDHPIIESKSDDKDKDKDKDKDKDKDKTKTTLPVKILSKAVDDFSQ
SIKDIIQKYTNNNPTVYVDQGTLLKVFVNKDIVFPKEAVRGINVVN

Sequences:

>Translated_446_residues
MSEENYNNHNNIELEESVNVVGTHKGKKAIIVGALVVVLGLTYYFFFNNKKTDDSTTTSKSSQEVDIEKLLKDSVPPAQE
VSPMVNIPPQLPELPPLVSPSLPSLPTIEKPKVLEVPKIVQKEKKIPAPLPTVETKSEPEVKIPLPTQNNVEVVTPIAPT
TTGYDKERRTTSMLTISGGQDLTAGQNNEEGTDPNNKIGNFVDSVMSFKPTSSPNVVATKINNLELTILQGKIIDVVLET
AINSDLQGTLRGIVARDVYSEAGNVVMIPKGSRLIGNYSFNASPGKTRVQISWNRVILPHGVDIALDSTGTDELGRQGAS
GVVDTKVGSILTSTILLAGVSIATSYVTSKIPEINDHPIIESKSDDKDKDKDKDKDKDKDKTKTTLPVKILSKAVDDFSQ
SIKDIIQKYTNNNPTVYVDQGTLLKVFVNKDIVFPKEAVRGINVVN
>Mature_445_residues
SEENYNNHNNIELEESVNVVGTHKGKKAIIVGALVVVLGLTYYFFFNNKKTDDSTTTSKSSQEVDIEKLLKDSVPPAQEV
SPMVNIPPQLPELPPLVSPSLPSLPTIEKPKVLEVPKIVQKEKKIPAPLPTVETKSEPEVKIPLPTQNNVEVVTPIAPTT
TGYDKERRTTSMLTISGGQDLTAGQNNEEGTDPNNKIGNFVDSVMSFKPTSSPNVVATKINNLELTILQGKIIDVVLETA
INSDLQGTLRGIVARDVYSEAGNVVMIPKGSRLIGNYSFNASPGKTRVQISWNRVILPHGVDIALDSTGTDELGRQGASG
VVDTKVGSILTSTILLAGVSIATSYVTSKIPEINDHPIIESKSDDKDKDKDKDKDKDKDKTKTTLPVKILSKAVDDFSQS
IKDIIQKYTNNNPTVYVDQGTLLKVFVNKDIVFPKEAVRGINVVN

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 48475; Mature: 48344

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEENYNNHNNIELEESVNVVGTHKGKKAIIVGALVVVLGLTYYFFFNNKKTDDSTTTSK
CCCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
SSQEVDIEKLLKDSVPPAQEVSPMVNIPPQLPELPPLVSPSLPSLPTIEKPKVLEVPKIV
CCCCCCHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
QKEKKIPAPLPTVETKSEPEVKIPLPTQNNVEVVTPIAPTTTGYDKERRTTSMLTISGGQ
HHHHCCCCCCCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEEEEECCC
DLTAGQNNEEGTDPNNKIGNFVDSVMSFKPTSSPNVVATKINNLELTILQGKIIDVVLET
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEECCHHHHHHHHH
AINSDLQGTLRGIVARDVYSEAGNVVMIPKGSRLIGNYSFNASPGKTRVQISWNRVILPH
HHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCEEEEEEECEEEECC
GVDIALDSTGTDELGRQGASGVVDTKVGSILTSTILLAGVSIATSYVTSKIPEINDHPII
CCEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ESKSDDKDKDKDKDKDKDKDKTKTTLPVKILSKAVDDFSQSIKDIIQKYTNNNPTVYVDQ
CCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GTLLKVFVNKDIVFPKEAVRGINVVN
CCEEEEEECCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
SEENYNNHNNIELEESVNVVGTHKGKKAIIVGALVVVLGLTYYFFFNNKKTDDSTTTSK
CCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
SSQEVDIEKLLKDSVPPAQEVSPMVNIPPQLPELPPLVSPSLPSLPTIEKPKVLEVPKIV
CCCCCCHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
QKEKKIPAPLPTVETKSEPEVKIPLPTQNNVEVVTPIAPTTTGYDKERRTTSMLTISGGQ
HHHHCCCCCCCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEEEEECCC
DLTAGQNNEEGTDPNNKIGNFVDSVMSFKPTSSPNVVATKINNLELTILQGKIIDVVLET
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEECCHHHHHHHHH
AINSDLQGTLRGIVARDVYSEAGNVVMIPKGSRLIGNYSFNASPGKTRVQISWNRVILPH
HHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCEEEEEEECEEEECC
GVDIALDSTGTDELGRQGASGVVDTKVGSILTSTILLAGVSIATSYVTSKIPEINDHPII
CCEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ESKSDDKDKDKDKDKDKDKDKTKTTLPVKILSKAVDDFSQSIKDIIQKYTNNNPTVYVDQ
CCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
GTLLKVFVNKDIVFPKEAVRGINVVN
CCEEEEEECCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]