Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 57651680

GI number: 57651680

Start: 1089797

End: 1090825

Strand: Direct

Name: purM [H]

Synonym: SACOL1080

Alternate gene names: 57651680

Gene position: 1089797-1090825 (Clockwise)

Preceding gene: 57651679

Following gene: 57651681

Centisome position: 38.79

GC content: 35.57

Gene sequence:

>1029_bases
ATGTCTAAAGCATATGAACAATCTGGTGTAAATATTCATGCTGGTTATGAAGCTGTAGAAAGAATGTCTAGTCATGTTAA
ACGTACGATGCGTAAAGAAGTTATCGGTGGTTTAGGTGGATTCGGTGCTACATTTGATTTATCACAATTAAATATGACAG
CGCCAGTTTTAGTTTCTGGAACAGACGGAGTAGGTACGAAATTAAAACTAGCTATCGACTATGGTAAACATGATTCGATA
GGTATCGATGCAGTCGCAATGTGTGTTAATGATATTTTAACGACAGGTGCAGAACCATTATATTTTTTAGATTACATTGC
TACAAACAAAGTTGTTCCTGAAGTTATTGAACAAATTGTTAAAGGTATTAGTGATGCATGTGTTGAAACGAATACTGCAC
TTATCGGTGGAGAGACTGCTGAAATGGGTGAAATGTATCACGAAGGCGAATATGATGTAGCTGGATTTGCTGTTGGAGCA
GTTGAAAAGGATGACTATGTAGATGGTTCAGAAGTGAAAGAGGGACAAGTTGTTATAGGGCTTGCGTCAAGTGGCATTCA
TTCAAATGGATACAGTTTAGTGCGCAAATTAATTAATGAATCAGGCATTGATTTGGCATCAAACTTCGATAATCGTCCAT
TTATCGATGTCTTTTTAGAACCAACTAAATTATATGTCAAACCTGTACTTGCTTTGAAAAAAGAAGTTTCTATTAAGGCA
ATGAATCATATTACTGGTGGAGGTTTTTATGAAAATATTCCACGTGCATTGCCAGCCGGATATGCTGCTAGAATTGATAC
TACATCATTTCCAACACCAAAAATATTTGATTGGTTACAACAACAAGGCAATATAGACACAAATGAAATGTATAACATTT
TTAATATGGGTATTGGCTATACGGTTATCGTTGATGAAAAAGATGTATCACGCGCTTTGAAGATTTTAGCAGAACAAAAT
GTGGAAGCCTATCAAATTGGTCATATTGTGAAAAATGAGTCAACTGCAATTGAATTGTTGGGGGTATAA

Upstream 100 bases:

>100_bases
TTATATGATTATGAAGCAAATTATAAAGCGCATTTAAGTCATCGACAAAAGCAATATATTTCTAAAAACAAACACTTTTT
TGATAGCGAGGGAAATTTAA

Downstream 100 bases:

>100_bases
CAATGGTTAAAATTGCGATTTTTGCATCAGGTTCAGGAAGTAACTTTGAAAATATAGTTGAGCATGTTGAATCAGGAAAA
CTTGAAAATATTGAAGTTAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSI
GIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGA
VEKDDYVDGSEVKEGQVVIGLASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQN
VEAYQIGHIVKNESTAIELLGV

Sequences:

>Translated_342_residues
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSI
GIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGA
VEKDDYVDGSEVKEGQVVIGLASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQN
VEAYQIGHIVKNESTAIELLGV
>Mature_341_residues
SKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSIG
IDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAV
EKDDYVDGSEVKEGQVVIGLASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKAM
NHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQNV
EAYQIGHIVKNESTAIELLGV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=45.5089820359281, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=45.5089820359281, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=45.5089820359281, Blast_Score=300, Evalue=1e-81,
Organism=Escherichia coli, GI1788845, Length=334, Percent_Identity=50.8982035928144, Blast_Score=344, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=40.4761904761905, Blast_Score=227, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=40.7079646017699, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24582400, Length=270, Percent_Identity=41.1111111111111, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37018; Mature: 36886

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSG
CCCCHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCEEEEC
TDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
KGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVKEGQVVIG
HHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
LASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
EECCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGY
HHHCCCCCHHHHCHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCE
TVIVDEKDVSRALKILAEQNVEAYQIGHIVKNESTAIELLGV
EEEECCHHHHHHHHHHHHCCCCCEEHHHEECCCCCEEEEECC
>Mature Secondary Structure 
SKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSG
CCCHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCEEEEC
TDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
KGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVKEGQVVIG
HHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
LASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
EECCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGY
HHHCCCCCHHHHCHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCE
TVIVDEKDVSRALKILAEQNVEAYQIGHIVKNESTAIELLGV
EEEECCHHHHHHHHHHHHCCCCCEEHHHEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA