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The map label for this gene is tkt [H]

Identifier: 57238656

GI number: 57238656

Start: 1710488

End: 1712386

Strand: Direct

Name: tkt [H]

Synonym: CJE1817

Alternate gene names: 57238656

Gene position: 1710488-1712386 (Clockwise)

Preceding gene: 57238655

Following gene: 57238657

Centisome position: 96.21

GC content: 35.91

Gene sequence:

>1899_bases
ATGGACATTCAAATTTTACAAGAACAGGCAAATACTCTAAGATTTTTAAGTGCCGATATGGTGCAAAAAGCAAACTCAGG
ACACCCAGGTGCACCTTTGGGTTTAGCAGATATTTTAAGTGTTTTAAGTTATCATTTAAAACACAATCCTAAAAATCCCA
CTTGGCTAAACCGCGATAGACTTGTATTTTCAGGCGGACATGCAAGTGCTTTGCTTTATAGTTTTTTACATTTAAGCGGC
TATGATTTAAGCCTAGAAGATCTTAAAAATTTCCGCCAACTTCATTCTAAAACCCCAGGACACCCTGAAATTTCAACTCT
TGGAGTAGAAATCGCTACAGGCCCTTTAGGACAAGGCGTTGCCAATGCTGTAGGCTTTGCTATGGCAGCAAAAAAAGCAC
AAAATTTGCTAGGCAGTGATTTAATCGATCATAAAATTTATTGTCTTTGCGGAGATGGGGATTTACAAGAAGGCATTTCT
TATGAAGCTTGTTCTTTAGCAGGACTTCACAAACTTGATAACTTCATACTTATTTATGATAGCAACAATATCTCCATAGA
AGGCGATGTAGGTTTAGCCTTTAACGAAAATGTAAAAATGCGTTTTGAAGCACAAGGATTTGAAGTTTTAAGTATAAATG
GACACGATTATGAAGAAATCAATAAAGCCTTAGAACAAGCTAAAAAATCCACAAAACCTTGTCTTATCATCGCAAAAACA
ACTATAGCAAAGGGTGCAGGAGAGCTTGAAGGCAGTCATAAAAGCCATGGCGCACCTTTGGGTGAAGAAGTGATTAAAAA
AGCCAAAGAACAAGCAGGTTTTGATCCAAATATCAGTTTTCATATCCCACAAGCAAGCAAAATCCGCTTTGAAAGTGCTG
TAGAACTTGGGGATTTAGAAGAAGCAAAATGGAAAGATAAGCTTGAAAAAAGTGCTAAAAAAGAACTTTTAGAAAGGCTA
TTAAATCCTGATTTTAACAAGATAGCTTATCCTGATTTTAAAGGAAAAGATCTTGCTACAAGAGATAGTAATGGTGAAAT
TTTAAATGTTTTAGCTAAAAATTTAGAAGGATTTTTAGGTGGAAGTGCAGACTTAGGCCCTTCAAACAAAACAGAACTTC
ACGGCATGGGAGACTTTGTAGAAGGTAAAAATATCCATTTTGGTATCAGAGAACACGCTATGGCAGCGATTAACAATGCT
TTTGCAAGATATGGAATTTTCTTACCATTTTCGGCAACTTTTTTCATCTTTAGCGAGTACTTAAAACCTGCCGCAAGAAT
AGCAGCTCTAATGAAAATCAAACATTTTTTCATTTTCACACACGATAGCATAGGCGTGGGCGAAGATGGACCAACACACC
AACCTATAGAACAACTTAGCACTTTTAGAGCTATGCCAAATTTTTTAACCTTTAGACCTGCTGATGGGGTGGAAAATGTC
AAAGCTTGGCAAATAGCCCTAAATGCTGATATTCCGAGTGCTTTTGTGCTTTCACGCCAAAAACTCAAAGCTCTAAATGA
ACCTGTTTTTGGAGATGTAAAAAATGGAGCGTATTTACTCAAAGAAAGCAAAGAGGCTAAATTTACACTTTTAGCAAGTG
GAAGTGAAGTTTGGCTTTGTTTAGAAAGTGCAAACGAACTTGAAAAACAAGGTTTTGCTTGTAATGTTGTTTCCATGCCT
TGTTTTGAACTTTTTGAAAAACAAGATAAAGCTTATCAAGAAAGATTGTTAAAAGGTGAAGTTATAGGTGTTGAAGCAGC
GCATTCTAATGAACTTTATAAATTTTGCCATAAAGTGTATGGCATAGAAAGTTTTGGAGAAAGTGGCAAAGACAAAGATG
TGTTTGAACACTTTGGATTTAGCGTTTCAAAGCTTGTAAATTTTATCCTTAGCAAATAA

Upstream 100 bases:

>100_bases
AAATCTTCTTAATGAATGCGAACAAGACTTAGAAAAACTTAATGAAAAACTCGCGCAAATGATACAAAATTTAATAATTC
AATACTTATAAAGGCAAAAA

Downstream 100 bases:

>100_bases
AATGAATACAAATTTCAAATTTCAAAATAACACTCTTTTTATCTTTGGAATTTGGGATAAAACAAGCATTTATAAGTTAA
AAATAAAAGATTTTTTAGCT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MDIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDRLVFSGGHASALLYSFLHLSG
YDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGVANAVGFAMAAKKAQNLLGSDLIDHKIYCLCGDGDLQEGIS
YEACSLAGLHKLDNFILIYDSNNISIEGDVGLAFNENVKMRFEAQGFEVLSINGHDYEEINKALEQAKKSTKPCLIIAKT
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLEEAKWKDKLEKSAKKELLERL
LNPDFNKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLGGSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNA
FARYGIFLPFSATFFIFSEYLKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKEAKFTLLASGSEVWLCLESANELEKQGFACNVVSMP
CFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVYGIESFGESGKDKDVFEHFGFSVSKLVNFILSK

Sequences:

>Translated_632_residues
MDIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDRLVFSGGHASALLYSFLHLSG
YDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGVANAVGFAMAAKKAQNLLGSDLIDHKIYCLCGDGDLQEGIS
YEACSLAGLHKLDNFILIYDSNNISIEGDVGLAFNENVKMRFEAQGFEVLSINGHDYEEINKALEQAKKSTKPCLIIAKT
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLEEAKWKDKLEKSAKKELLERL
LNPDFNKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLGGSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNA
FARYGIFLPFSATFFIFSEYLKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKEAKFTLLASGSEVWLCLESANELEKQGFACNVVSMP
CFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVYGIESFGESGKDKDVFEHFGFSVSKLVNFILSK
>Mature_632_residues
MDIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDRLVFSGGHASALLYSFLHLSG
YDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGVANAVGFAMAAKKAQNLLGSDLIDHKIYCLCGDGDLQEGIS
YEACSLAGLHKLDNFILIYDSNNISIEGDVGLAFNENVKMRFEAQGFEVLSINGHDYEEINKALEQAKKSTKPCLIIAKT
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLEEAKWKDKLEKSAKKELLERL
LNPDFNKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLGGSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNA
FARYGIFLPFSATFFIFSEYLKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKEAKFTLLASGSEVWLCLESANELEKQGFACNVVSMP
CFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVYGIESFGESGKDKDVFEHFGFSVSKLVNFILSK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=591, Percent_Identity=28.4263959390863, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4507521, Length=591, Percent_Identity=28.4263959390863, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI133778974, Length=645, Percent_Identity=26.046511627907, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI225637459, Length=650, Percent_Identity=24.3076923076923, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI225637463, Length=540, Percent_Identity=24.8148148148148, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI225637461, Length=540, Percent_Identity=24.8148148148148, Blast_Score=132, Evalue=1e-30,
Organism=Escherichia coli, GI48994911, Length=654, Percent_Identity=44.954128440367, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1788808, Length=651, Percent_Identity=43.778801843318, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17539652, Length=594, Percent_Identity=29.6296296296296, Blast_Score=208, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6325331, Length=642, Percent_Identity=44.8598130841121, Blast_Score=483, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6319593, Length=642, Percent_Identity=40.9657320872274, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=26.2672811059908, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=26.2672811059908, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24666278, Length=598, Percent_Identity=27.257525083612, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24645119, Length=615, Percent_Identity=25.6910569105691, Blast_Score=170, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 69589; Mature: 69589

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCC
LVFSGGHASALLYSFLHLSGYDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGV
EEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHH
ANAVGFAMAAKKAQNLLGSDLIDHKIYCLCGDGDLQEGISYEACSLAGLHKLDNFILIYD
HHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCHHHCCCCCHHHHHHHHHCCCEEEEEE
SNNISIEGDVGLAFNENVKMRFEAQGFEVLSINGHDYEEINKALEQAKKSTKPCLIIAKT
CCCEEEECCEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEC
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLE
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHCCHHHHCCCCCCH
EAKWKDKLEKSAKKELLERLLNPDFNKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNAFARYGIFLPFSATFFIFSEY
CCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCEEECHHHHHHHHHHH
LKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
HHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKEAKFTLLASGSEVWLC
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCEEEEE
LESANELEKQGFACNVVSMPCFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVY
ECCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
GIESFGESGKDKDVFEHFGFSVSKLVNFILSK
CHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MDIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCC
LVFSGGHASALLYSFLHLSGYDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGV
EEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHH
ANAVGFAMAAKKAQNLLGSDLIDHKIYCLCGDGDLQEGISYEACSLAGLHKLDNFILIYD
HHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCHHHCCCCCHHHHHHHHHCCCEEEEEE
SNNISIEGDVGLAFNENVKMRFEAQGFEVLSINGHDYEEINKALEQAKKSTKPCLIIAKT
CCCEEEECCEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEC
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLE
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHCCHHHHCCCCCCH
EAKWKDKLEKSAKKELLERLLNPDFNKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNAFARYGIFLPFSATFFIFSEY
CCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCEEECHHHHHHHHHHH
LKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
HHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKEAKFTLLASGSEVWLC
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCEEEEE
LESANELEKQGFACNVVSMPCFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVY
ECCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
GIESFGESGKDKDVFEHFGFSVSKLVNFILSK
CHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]