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The map label for this gene is ispA [H]

Identifier: 57238655

GI number: 57238655

Start: 1709633

End: 1710478

Strand: Direct

Name: ispA [H]

Synonym: CJE1816

Alternate gene names: 57238655

Gene position: 1709633-1710478 (Clockwise)

Preceding gene: 57238654

Following gene: 57238656

Centisome position: 96.16

GC content: 32.27

Gene sequence:

>846_bases
GTGAATTTAAAAGAACTTTTTATCCATCACTTAGAAAAAAATCTACCTAAAGTTGAAAGCTTTCATCCTTTTTTTAATGA
AGCTTTAGCCCTTATGCTAAAAGCGGGAGGAAAGCATTTTCGCGCACAATTGCTTTTAAGCGTAGTACAAAGCAATAAAC
CTGAACTTTTAAATCAAGCTTTAGATGTGGCTTTAGCTTTGGAATTTATCCATACTTATTCACTCATACACGATGATTTA
CCCGCTATGGATAATGCAGACTTTAGACGAGGAATTCCAACCTTACACAAAAGCTACGATGAAACTACAGCCATCTTAGT
GGGTGATGCTTTAAATACTGAAGCTTTTTTAGTTCTAAGTCATGCTCATTTAAAAGATGAAATCAAAATCAAACTCATCA
AAACCCTTGCCTTTAATGCAGGACTTAATGGAATGGTCATAGGACAAGCTATTGATTGTTTTTTTGAAGACAAAAGACTG
AGTTTAAATGAACTTGAGTTTTTACACACACATAAAACCGCAAGATTAATCGCTGCAGCTTTAAAAATGGGTTGTGAAAT
TTGCGAACTTAACAACGAAGAAAGCAACCAAATTTACAAACTTGGTTTAAAACTAGGACTGATTTTTCAAATCAATGATG
ATATTATCGATGTAACTACAAGTCAAGAACAAAGCGGAAAGCCTACTAATAACGATATTCATAAAAATTCTTTTGTCAAT
TTGCTTGGACTTGAACAAGCCATAAAAACAAAAGAAAATCTTCTTAATGAATGCGAACAAGACTTAGAAAAACTTAATGA
AAAACTCGCGCAAATGATACAAAATTTAATAATTCAATACTTATAA

Upstream 100 bases:

>100_bases
AAAGTACTAAATTACCTTTATCAAATTTCAACAATGAACTAGGCGGAAATGCCAACTCAGGTGGCGATGGTAAATTTCAA
TTTTTCATAAGGCTTACTAA

Downstream 100 bases:

>100_bases
AGGCAAAAAATGGACATTCAAATTTTACAAGAACAGGCAAATACTCTAAGATTTTTAAGTGCCGATATGGTGCAAAAAGC
AAACTCAGGACACCCAGGTG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNLKELFIHHLEKNLPKVESFHPFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHDDL
PAMDNADFRRGIPTLHKSYDETTAILVGDALNTEAFLVLSHAHLKDEIKIKLIKTLAFNAGLNGMVIGQAIDCFFEDKRL
SLNELEFLHTHKTARLIAAALKMGCEICELNNEESNQIYKLGLKLGLIFQINDDIIDVTTSQEQSGKPTNNDIHKNSFVN
LLGLEQAIKTKENLLNECEQDLEKLNEKLAQMIQNLIIQYL

Sequences:

>Translated_281_residues
MNLKELFIHHLEKNLPKVESFHPFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHDDL
PAMDNADFRRGIPTLHKSYDETTAILVGDALNTEAFLVLSHAHLKDEIKIKLIKTLAFNAGLNGMVIGQAIDCFFEDKRL
SLNELEFLHTHKTARLIAAALKMGCEICELNNEESNQIYKLGLKLGLIFQINDDIIDVTTSQEQSGKPTNNDIHKNSFVN
LLGLEQAIKTKENLLNECEQDLEKLNEKLAQMIQNLIIQYL
>Mature_281_residues
MNLKELFIHHLEKNLPKVESFHPFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHDDL
PAMDNADFRRGIPTLHKSYDETTAILVGDALNTEAFLVLSHAHLKDEIKIKLIKTLAFNAGLNGMVIGQAIDCFFEDKRL
SLNELEFLHTHKTARLIAAALKMGCEICELNNEESNQIYKLGLKLGLIFQINDDIIDVTTSQEQSGKPTNNDIHKNSFVN
LLGLEQAIKTKENLLNECEQDLEKLNEKLAQMIQNLIIQYL

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=245, Percent_Identity=40.8163265306122, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789578, Length=216, Percent_Identity=27.3148148148148, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24651612, Length=184, Percent_Identity=30.9782608695652, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31752; Mature: 31752

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKELFIHHLEKNLPKVESFHPFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQA
CCHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
LDVALALEFIHTYSLIHDDLPAMDNADFRRGIPTLHKSYDETTAILVGDALNTEAFLVLS
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHCCCCCEEEEEECCCCCCEEEEEE
HAHLKDEIKIKLIKTLAFNAGLNGMVIGQAIDCFFEDKRLSLNELEFLHTHKTARLIAAA
HHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LKMGCEICELNNEESNQIYKLGLKLGLIFQINDDIIDVTTSQEQSGKPTNNDIHKNSFVN
HHHCCHHEECCCCCCCHHEEEHHEEEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHH
LLGLEQAIKTKENLLNECEQDLEKLNEKLAQMIQNLIIQYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLKELFIHHLEKNLPKVESFHPFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQA
CCHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
LDVALALEFIHTYSLIHDDLPAMDNADFRRGIPTLHKSYDETTAILVGDALNTEAFLVLS
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHCCCCCEEEEEECCCCCCEEEEEE
HAHLKDEIKIKLIKTLAFNAGLNGMVIGQAIDCFFEDKRLSLNELEFLHTHKTARLIAAA
HHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LKMGCEICELNNEESNQIYKLGLKLGLIFQINDDIIDVTTSQEQSGKPTNNDIHKNSFVN
HHHCCHHEECCCCCCCHHEEEHHEEEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHH
LLGLEQAIKTKENLLNECEQDLEKLNEKLAQMIQNLIIQYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]