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The map label for this gene is yrkA [H]

Identifier: 57237188

GI number: 57237188

Start: 177400

End: 178686

Strand: Direct

Name: yrkA [H]

Synonym: CJE0176

Alternate gene names: 57237188

Gene position: 177400-178686 (Clockwise)

Preceding gene: 57237187

Following gene: 57237199

Centisome position: 9.98

GC content: 32.09

Gene sequence:

>1287_bases
ATGGTTGTTGTTGCACTTGCTCTAGTGTTTTTAAATGGTTTTTTTGTTTTGTCTGAATTTAGTATTGTTAAAGTACGTCG
TTCCAAGCTTGAAGAGATGGTAAAAGAAAAAAAAGCTGGTGCCAAGAAAGCTTTGGAGGTTACTTCAAGACTTGATACTT
ATCTTAGTGCTTGTCAATTAGGAATCACTTTAAGTTCTCTAGCTCTTGGTTGGATAGGTGAGCCTGCTATTGCAAAAATG
CTAGAAATTCCGCTTATTAATCTTGGTTTTAGCACTGTTATTATCCATACTATGGCTTTCATTATTGCTTTTAGCATTAT
TACTCTTTTACATGTGGTTTTAGGAGAACTTGTGCCAAAAAGTATAGCTATTGCAGTTGCAGATAAAGCGGTTTTATTTA
TAGCTAGACCGCTTCATTGGTTTTGGATGCTCTTTTTGCCTTGTATTAAAATTTTCGATTTTTTAGCAGCTATAAGTTTG
AAACTTTTTGGAATAAAACCTGCTAAAGAAAGCGAGCTAACTCATAGCGAAGAAGAAATTAAAATCATAGCAAGTGAGAG
TCAAAAAGGTGGAGTTTTAGATGAATTTGAAACAGAGATCATACGCAATGCTGTTGATTTTTCAGATACTGTTGCTAAAG
AGATTATGACTCCTAGAAAAGATATGATTTGTCTAAATAAACAAAAAAGTTACGAAGAAAATATGCAAATCATTTGTGAG
CATAAACATACTCGCTTTCCTTATATTGATGGTTCTAAAGATACTATTTTAGGTATGATACACATACGAGATATAATACA
AAATGAATTAAACCATAAAAGTCAAAATTTAGATACTTTTGTTAAACCTTTGATTTTGGTTCCTGAAAATATCAGCATTT
CAAAAGTACTTGTAATGATGAATAAAGAACTCTCTCATACTGCATTAGTAGTTGATGAGTATGGTGGAACTGCTGGAATT
TTAACCATGGAAGATATCATGGAAGAAATTATTGGCGAAATTAAAAGCGAGCATGAAGAAGACAGCTATAAAAAACTTGC
TGAAAATATCTATGAATTTCAAGGACGATGCGATATAGAAACTGTTGAAGAAATGCTTGTAATAAACTATGATGAGGATT
TAGAACAAGTTACTATAGGTGGTTATGTATTTAATCTTTTAGGACGCTTGCCTATGGTAGGAGATCGCATTGAAGATGAA
CTTTGTTACTATGAAGTTAAAAAAATGGATGGGAATTCTATAGAGCGTGTTAAGGTGGTTAAAAAAACAAATAAAGATGA
AGAATAA

Upstream 100 bases:

>100_bases
ATAATATTTTATTTCTTAAGGAGCTTCATTGGACCCCAGTCAGGTTTTGGATTTAAACCAAACTTCTACAGCATCTTTTG
ATGCAGGATATTCTATACTT

Downstream 100 bases:

>100_bases
GCCTCTTTAGGCTTTATTTCTTTTTGTAAATTTGGTTTTTAATTTCTATACACTCAAAACCTTTTTCATCTAGTGTAACT
ACGCGTAAATATCCACCATC

Product: transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MVVVALALVFLNGFFVLSEFSIVKVRRSKLEEMVKEKKAGAKKALEVTSRLDTYLSACQLGITLSSLALGWIGEPAIAKM
LEIPLINLGFSTVIIHTMAFIIAFSIITLLHVVLGELVPKSIAIAVADKAVLFIARPLHWFWMLFLPCIKIFDFLAAISL
KLFGIKPAKESELTHSEEEIKIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKSYEENMQIICE
HKHTRFPYIDGSKDTILGMIHIRDIIQNELNHKSQNLDTFVKPLILVPENISISKVLVMMNKELSHTALVVDEYGGTAGI
LTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDE
LCYYEVKKMDGNSIERVKVVKKTNKDEE

Sequences:

>Translated_428_residues
MVVVALALVFLNGFFVLSEFSIVKVRRSKLEEMVKEKKAGAKKALEVTSRLDTYLSACQLGITLSSLALGWIGEPAIAKM
LEIPLINLGFSTVIIHTMAFIIAFSIITLLHVVLGELVPKSIAIAVADKAVLFIARPLHWFWMLFLPCIKIFDFLAAISL
KLFGIKPAKESELTHSEEEIKIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKSYEENMQIICE
HKHTRFPYIDGSKDTILGMIHIRDIIQNELNHKSQNLDTFVKPLILVPENISISKVLVMMNKELSHTALVVDEYGGTAGI
LTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDE
LCYYEVKKMDGNSIERVKVVKKTNKDEE
>Mature_428_residues
MVVVALALVFLNGFFVLSEFSIVKVRRSKLEEMVKEKKAGAKKALEVTSRLDTYLSACQLGITLSSLALGWIGEPAIAKM
LEIPLINLGFSTVIIHTMAFIIAFSIITLLHVVLGELVPKSIAIAVADKAVLFIARPLHWFWMLFLPCIKIFDFLAAISL
KLFGIKPAKESELTHSEEEIKIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKSYEENMQIICE
HKHTRFPYIDGSKDTILGMIHIRDIIQNELNHKSQNLDTFVKPLILVPENISISKVLVMMNKELSHTALVVDEYGGTAGI
LTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDE
LCYYEVKKMDGNSIERVKVVKKTNKDEE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=386, Percent_Identity=39.8963730569948, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1790664, Length=427, Percent_Identity=23.1850117096019, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1786879, Length=257, Percent_Identity=28.0155642023346, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI145693175, Length=431, Percent_Identity=22.5058004640371, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082033, Length=237, Percent_Identity=25.7383966244726, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788119, Length=239, Percent_Identity=21.3389121338912, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48412; Mature: 48412

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVVALALVFLNGFFVLSEFSIVKVRRSKLEEMVKEKKAGAKKALEVTSRLDTYLSACQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GITLSSLALGWIGEPAIAKMLEIPLINLGFSTVIIHTMAFIIAFSIITLLHVVLGELVPK
HHHHHHHHHHCCCCHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SIAIAVADKAVLFIARPLHWFWMLFLPCIKIFDFLAAISLKLFGIKPAKESELTHSEEEI
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHE
KIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKSYEENMQIICE
EEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHEEECCCCCHHHHHHEEEC
HKHTRFPYIDGSKDTILGMIHIRDIIQNELNHKSQNLDTFVKPLILVPENISISKVLVMM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCCHHHHHHHH
NKELSHTALVVDEYGGTAGILTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIE
CCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
TVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDELCYYEVKKMDGNSIERVKVV
HHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
KKTNKDEE
HHCCCCCC
>Mature Secondary Structure
MVVVALALVFLNGFFVLSEFSIVKVRRSKLEEMVKEKKAGAKKALEVTSRLDTYLSACQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GITLSSLALGWIGEPAIAKMLEIPLINLGFSTVIIHTMAFIIAFSIITLLHVVLGELVPK
HHHHHHHHHHCCCCHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SIAIAVADKAVLFIARPLHWFWMLFLPCIKIFDFLAAISLKLFGIKPAKESELTHSEEEI
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHE
KIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKSYEENMQIICE
EEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHEEECCCCCHHHHHHEEEC
HKHTRFPYIDGSKDTILGMIHIRDIIQNELNHKSQNLDTFVKPLILVPENISISKVLVMM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCCHHHHHHHH
NKELSHTALVVDEYGGTAGILTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIE
CCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
TVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDELCYYEVKKMDGNSIERVKVV
HHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
KKTNKDEE
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]