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The map label for this gene is folE [H]

Identifier: 57237199

GI number: 57237199

Start: 187625

End: 188197

Strand: Direct

Name: folE [H]

Synonym: CJE0187

Alternate gene names: 57237199

Gene position: 187625-188197 (Clockwise)

Preceding gene: 57237188

Following gene: 57237200

Centisome position: 10.55

GC content: 32.46

Gene sequence:

>573_bases
TTGCAAAAAAAATTTGAAGATTGTGTTAAAACCATACTTGAAATTATAGGAGAAAATCCAAATCGTGAAGGGCTTATTAA
AACACCAAATCGTGTTTTTAAAGCTTATGAATTTCTTGCTAGTGGTTATACGCAAAATGTCAAAGACATTTTAAATGATG
CTTTATTTGAAAGCTCTAATAATGAAATGGTTTTGGTGCGTGATATAGAATTTTATAGTCTTTGCGAACATCATCTTTTA
CCTTTTTTTGGGCGTGCTCATGTAGCCTATATCCCTAATAAAAAAGTAGTAGGTTTAAGCAAAATTCCACGCCTTGTAGA
AGTGTTTGCAAGAAGACTTCAAATTCAAGAACAACTTACTGAACAAATCGCACAAGCTTTAATGGAAAATGTTGATGCAA
AAGGTGTGGGTGTAGTCATAGAAGCAAGACATATGTGTGTTGAAATGCGTGGAATACAAAAAGCTAATTCCACCACTACA
ACTTCAGCTTTACGTGGAATTTTCTTAAAAAATGAAAAAACCAGAGAGGAATTTTTTTCTCTCATAAACTCTGCTAAACA
GGTAAGATTTTAA

Upstream 100 bases:

>100_bases
AATTTTTCCTTATTACTTGCATAAAATTTTAAAGTAATTTATGATAAAATTGCAATATTACATTATTATTAAAATATAAA
AAATATTTTTGGAGAAAAAT

Downstream 100 bases:

>100_bases
TGAATCTTGAAAAACTACGCTCCAAACTTGGTAAAGAAAATTTAAGTGCTATCTTTGGAGAGATTACAAAAATTTCTGCT
ACGAGTATAGAAATTCGTGG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MQKKFEDCVKTILEIIGENPNREGLIKTPNRVFKAYEFLASGYTQNVKDILNDALFESSNNEMVLVRDIEFYSLCEHHLL
PFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLTEQIAQALMENVDAKGVGVVIEARHMCVEMRGIQKANSTTT
TSALRGIFLKNEKTREEFFSLINSAKQVRF

Sequences:

>Translated_190_residues
MQKKFEDCVKTILEIIGENPNREGLIKTPNRVFKAYEFLASGYTQNVKDILNDALFESSNNEMVLVRDIEFYSLCEHHLL
PFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLTEQIAQALMENVDAKGVGVVIEARHMCVEMRGIQKANSTTT
TSALRGIFLKNEKTREEFFSLINSAKQVRF
>Mature_190_residues
MQKKFEDCVKTILEIIGENPNREGLIKTPNRVFKAYEFLASGYTQNVKDILNDALFESSNNEMVLVRDIEFYSLCEHHLL
PFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLTEQIAQALMENVDAKGVGVVIEARHMCVEMRGIQKANSTTT
TSALRGIFLKNEKTREEFFSLINSAKQVRF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=174, Percent_Identity=54.5977011494253, Blast_Score=224, Evalue=3e-59,
Organism=Homo sapiens, GI4503949, Length=174, Percent_Identity=54.5977011494253, Blast_Score=224, Evalue=3e-59,
Organism=Homo sapiens, GI66932972, Length=132, Percent_Identity=53.7878787878788, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI66932970, Length=132, Percent_Identity=53.7878787878788, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1788476, Length=172, Percent_Identity=42.4418604651163, Blast_Score=117, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=174, Percent_Identity=55.1724137931034, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=54.3956043956044, Blast_Score=210, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24656782, Length=175, Percent_Identity=52.5714285714286, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24656791, Length=175, Percent_Identity=52.5714285714286, Blast_Score=200, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24656796, Length=175, Percent_Identity=52.5714285714286, Blast_Score=199, Evalue=7e-52,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21753; Mature: 21753

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKFEDCVKTILEIIGENPNREGLIKTPNRVFKAYEFLASGYTQNVKDILNDALFESSN
CCCHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
NEMVLVRDIEFYSLCEHHLLPFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLT
CCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHH
EQIAQALMENVDAKGVGVVIEARHMCVEMRGIQKANSTTTTSALRGIFLKNEKTREEFFS
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHH
LINSAKQVRF
HHHHHHHCCC
>Mature Secondary Structure
MQKKFEDCVKTILEIIGENPNREGLIKTPNRVFKAYEFLASGYTQNVKDILNDALFESSN
CCCHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
NEMVLVRDIEFYSLCEHHLLPFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLT
CCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHH
EQIAQALMENVDAKGVGVVIEARHMCVEMRGIQKANSTTTTSALRGIFLKNEKTREEFFS
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHH
LINSAKQVRF
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA