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The map label for this gene is metA

Identifier: 57236911

GI number: 57236911

Start: 1771852

End: 1772733

Strand: Reverse

Name: metA

Synonym: CJE1894

Alternate gene names: 57236911

Gene position: 1772733-1771852 (Counterclockwise)

Preceding gene: 57236912

Following gene: 57236909

Centisome position: 99.71

GC content: 31.18

Gene sequence:

>882_bases
ATGCCACTGATTATTCCAGAAAATATACCCGCTTATGAGCTTTTAAAAGAGCATGCTTTTATCATGGGATTAAGGAGAGC
AAAGCATCAAGATATCAGGCCGCAAGAAATTTTGATTGTCAATCTTATGCCAAAAAAAATTGAAACAGAAAATCAAATTC
TAAGCTTACTTGCAAATTCTCCTTTGCAAGTAAATATCACACTTTTAGCCACGACTAGCTATGTGGGTAAAAATACTCCT
TTTACTCATTTGGAAAAATTTTACAAGGGTCTTGAAGAGGTTAAAAAACATAAATTTGACGGTGCTATCGTTACGGGAGC
TCCTGTGGAACAAATGGATTTTGAAAAGGTTGCTTACTGGGAAGAATTGCTAGAAATTTTTGATTTTTTAAAGCAAAATG
TAACAAGTTCTATGTATATTTGTTGGGGTGCCATGGCTGCTTTAAAATACTTTTATGGTGTGGATAAAATCTCTTTAGAT
AAGAAAATTTTTGGAGTCTATAAGCATGATAAAGTTTCGCCTGATCTGCTTTTAACAAATTTAGATGAAAAGGTTTTAAT
GCCTCATTCAAGACATTCTAGCATGGATGAAGAGCAAATTTTAGCACTACAAAAACAAGGGAAATTAAAAATTTTGCTTA
GAAATAAAAAAATCGGTTCGGCTTTATTAAGAGATGAAAAGAATATTTTTATTTTAGGGCATTTGGAATATTTTAAAGAG
ACTTTACATCAAGAATATGTAAGAGATAATTTCATACAAAAAGCTAAAAATTATTATGATAAAAAGGGCAATATAAAATA
CAATTGGCGTTCAAATGCAAATACCATTTTTGCAAATTGGCTCAATTATGATGTGTATCAAAGCACACCTTTTGTGCTTT
GA

Upstream 100 bases:

>100_bases
AAGCTATAGAAAGTTAAAAGTGTGTTTGCATTGAGTGGAATGAGATAAAAATTCCATCATGCTTTATCATAAATAAGGTT
TATTAAATAAAGGAGAAAAA

Downstream 100 bases:

>100_bases
TGATTTAAACTCTTGTAGTAGGTGTATCGTGATATACGCTTACTGCACCTTTGATATCGCTTAAAATCGCGCAAGCTGCT
TCATTGGCACTTCCCATCGC

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPLIIPENIPAYELLKEHAFIMGLRRAKHQDIRPQEILIVNLMPKKIETENQILSLLANSPLQVNITLLATTSYVGKNTP
FTHLEKFYKGLEEVKKHKFDGAIVTGAPVEQMDFEKVAYWEELLEIFDFLKQNVTSSMYICWGAMAALKYFYGVDKISLD
KKIFGVYKHDKVSPDLLLTNLDEKVLMPHSRHSSMDEEQILALQKQGKLKILLRNKKIGSALLRDEKNIFILGHLEYFKE
TLHQEYVRDNFIQKAKNYYDKKGNIKYNWRSNANTIFANWLNYDVYQSTPFVL

Sequences:

>Translated_293_residues
MPLIIPENIPAYELLKEHAFIMGLRRAKHQDIRPQEILIVNLMPKKIETENQILSLLANSPLQVNITLLATTSYVGKNTP
FTHLEKFYKGLEEVKKHKFDGAIVTGAPVEQMDFEKVAYWEELLEIFDFLKQNVTSSMYICWGAMAALKYFYGVDKISLD
KKIFGVYKHDKVSPDLLLTNLDEKVLMPHSRHSSMDEEQILALQKQGKLKILLRNKKIGSALLRDEKNIFILGHLEYFKE
TLHQEYVRDNFIQKAKNYYDKKGNIKYNWRSNANTIFANWLNYDVYQSTPFVL
>Mature_292_residues
PLIIPENIPAYELLKEHAFIMGLRRAKHQDIRPQEILIVNLMPKKIETENQILSLLANSPLQVNITLLATTSYVGKNTPF
THLEKFYKGLEEVKKHKFDGAIVTGAPVEQMDFEKVAYWEELLEIFDFLKQNVTSSMYICWGAMAALKYFYGVDKISLDK
KIFGVYKHDKVSPDLLLTNLDEKVLMPHSRHSSMDEEQILALQKQGKLKILLRNKKIGSALLRDEKNIFILGHLEYFKET
LHQEYVRDNFIQKAKNYYDKKGNIKYNWRSNANTIFANWLNYDVYQSTPFVL

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=307, Percent_Identity=42.0195439739414, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_CAMJE (Q9PLV2)

Other databases:

- EMBL:   AL111168
- PIR:   B81271
- RefSeq:   YP_002345092.1
- ProteinModelPortal:   Q9PLV2
- SMR:   Q9PLV2
- IntAct:   Q9PLV2
- GeneID:   906001
- GenomeReviews:   AL111168_GR
- KEGG:   cje:Cj1726c
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q9PLV2
- ProtClustDB:   PRK05368
- BioCyc:   CJEJ192222:CJ1726C-MONOMER
- BRENDA:   2.3.1.46
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 34194; Mature: 34063

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: ACT_SITE 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIIPENIPAYELLKEHAFIMGLRRAKHQDIRPQEILIVNLMPKKIETENQILSLLANS
CCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHCHHHHHHHHHCCC
PLQVNITLLATTSYVGKNTPFTHLEKFYKGLEEVKKHKFDGAIVTGAPVEQMDFEKVAYW
CEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
EELLEIFDFLKQNVTSSMYICWGAMAALKYFYGVDKISLDKKIFGVYKHDKVSPDLLLTN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHEECCCCCCCCCCEEEC
LDEKVLMPHSRHSSMDEEQILALQKQGKLKILLRNKKIGSALLRDEKNIFILGHLEYFKE
CCHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCEEEEECHHHHHH
TLHQEYVRDNFIQKAKNYYDKKGNIKYNWRSNANTIFANWLNYDVYQSTPFVL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHCCCCCCC
>Mature Secondary Structure 
PLIIPENIPAYELLKEHAFIMGLRRAKHQDIRPQEILIVNLMPKKIETENQILSLLANS
CEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHCHHHHHHHHHCCC
PLQVNITLLATTSYVGKNTPFTHLEKFYKGLEEVKKHKFDGAIVTGAPVEQMDFEKVAYW
CEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
EELLEIFDFLKQNVTSSMYICWGAMAALKYFYGVDKISLDKKIFGVYKHDKVSPDLLLTN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHEECCCCCCCCCCEEEC
LDEKVLMPHSRHSSMDEEQILALQKQGKLKILLRNKKIGSALLRDEKNIFILGHLEYFKE
CCHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCEEEEECHHHHHH
TLHQEYVRDNFIQKAKNYYDKKGNIKYNWRSNANTIFANWLNYDVYQSTPFVL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204