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The map label for this gene is nuoG [C]

Identifier: 57235003

GI number: 57235003

Start: 143111

End: 144832

Strand: Direct

Name: nuoG [C]

Synonym: DET0147

Alternate gene names: 57235003

Gene position: 143111-144832 (Clockwise)

Preceding gene: 57235004

Following gene: 57235002

Centisome position: 9.74

GC content: 53.19

Gene sequence:

>1722_bases
ATGGTTACGCTAAATATTGACAACAAGCAGATAAGCGTACCTGAAGGTACGACTATTATGCAGGCCGCCAAGCAGGCCAA
TATCAATATCCCCCACCTGTGTTATTTTGAAGGCCTGAAAAGTTACAGCGGCTGCCGGGTATGTGTGGTGGAAATAGAGG
GTGAACCCCGTCTGGCTACGTCCTGCTCACGCAAGGTAGCCGAAGGCATGAAGGTTAATACCCATTCCGCCAGAGTACGC
CGCGCCCGCCGCACCATACTTGAAATCCTGCTGGCCAATCACCCGCAGGACTGTTTTAACTGTGAGCGCAACCAGAACTG
TGATTTGCTGCGTCTGGCGTTTGAATGCGGAGTTAAAAAGCTGCGCTTTGAAGAAAGCGAAAAGCGGGTGCTGCCTATAG
ACAGTACCAGCCCCAGTATTATCCGTGACCCCAATAAATGTATTGCCTGCGGCCGGTGTGTCCGCGTCTGCCACGATATA
CAAACAGTCAATGCCATCGGTTTTATAAATAAAGGCCCGGATACCATGGTGGCAACCTCCATGGACAGGGGTATGGGCAA
TGTTGCCTGTGCCAACTGCGGCCAGTGCATACTGGTCTGCCCGGTGGGTGCTATCAAGGAACGCTCGGCGGTGGATGCTG
TCTGGGCGGCTATAGCAGACCCCACTAAACACGTGGTTGTTCAGGAAGCTCCTTCGGTCAGGGTTTCTCTGGGCGAAGAG
CTGGGCTTGCCGGCAGGTACGCTGGTTGCCAAAAAGATGTATGCCGCTTTAAGGCGTCTGGGTTTTGACGCCGTATTTGA
TACCAACTTTACCGCTGACCTGACCATTATGGAAGAGGGTTCGGAACTGGTGGAACGGGTTAAGGACGGCGGGGTGCTTC
CCCAGATAACCTCCTGCTGCCCCGGCTGGGTCAAGTTTATGGAGCATTATTATCCTGAACTTGCGCCCAACGTTTCCTCC
GCCAAGTCCCCCCAGCAAATGTTCGGGGCGGTCTGCAAGACCTATTATGCCGAAAAATCCGGCATAGACCCCAAGGATAT
TATCAATGTTTCGGTCATGCCCTGTACGGCCAAGAAATTTGAGTGCCAGCGTCCCGAAATGAATGACAGCGGCTTTAAAG
ACGTGGATTATGTCTTGACTACCCGTGAGCTGGCCCGGATGATAAAAGAAGCCGGACTGGATTTTGCTTCACTGGACGAA
GAGCCTGCCGAAGACTTGCTGGGTCTTTATACCGGTGCCGCCACTATCTTCGGGGCTACCGGCGGTGTTATGGAAGCGGC
TATCCGCAGTGCCTACACCCTGATAACCGGGCGCGAACTGGAAAACCTGGATATAGAACCGGTGCGCGGTCTGGAAGGCA
TTAAGACCGCCAGCGTTAATATTGACGGGTTAGAGGTTAAAGTAGCGGTGGCTCACGGGCTGGGAAATGCCCGTCACCTG
CTGGATGAGATAAAAGAGGGTGTTTCGCCCTACCACTTTATAGAAATCATGGCCTGTCCCGGCGGTTGTGTCGGCGGCGG
CGGCCAGCCAATACGCTTTGATTCCACTCTCAAGAAAAAGCGCGGCGAAGCCCTTTACGAAGAAGACAGAAACATGGCCA
AGAGGTGTTCCCACCACAACCCGTCAGTAGAGAAGATATATAAAGACTATCTGGAGAAGCCGCTGGGCAAGCGTTCTCAC
AAACTGCTGCATACCGAATATACCAGTCGCCCGGTAGTTTAA

Upstream 100 bases:

>100_bases
CTTCCTGCGGTCTGGGACAGGTAGCCTTAAATGTGGCTGCCAGTGCCATTCGCAACTTCAAGGGTGAATTCTTGGCGCAG
GTGCGTAAGGAGGAAGGCGT

Downstream 100 bases:

>100_bases
GGGCAAGTAATAAAAACAATACGCGGGAGGAACAAAATAGATGTTCAATATCCAGAGTATCAGCCTTAGGAAAGAGCTTG
TTATTGCTTTTTTAGTTATG

Product: [Fe] hydrogenase, large subunit HymC, putative

Products: NA

Alternate protein names: CpI; Fe-only hydrogenase; [Fe] hydrogenase [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MVTLNIDNKQISVPEGTTIMQAAKQANINIPHLCYFEGLKSYSGCRVCVVEIEGEPRLATSCSRKVAEGMKVNTHSARVR
RARRTILEILLANHPQDCFNCERNQNCDLLRLAFECGVKKLRFEESEKRVLPIDSTSPSIIRDPNKCIACGRCVRVCHDI
QTVNAIGFINKGPDTMVATSMDRGMGNVACANCGQCILVCPVGAIKERSAVDAVWAAIADPTKHVVVQEAPSVRVSLGEE
LGLPAGTLVAKKMYAALRRLGFDAVFDTNFTADLTIMEEGSELVERVKDGGVLPQITSCCPGWVKFMEHYYPELAPNVSS
AKSPQQMFGAVCKTYYAEKSGIDPKDIINVSVMPCTAKKFECQRPEMNDSGFKDVDYVLTTRELARMIKEAGLDFASLDE
EPAEDLLGLYTGAATIFGATGGVMEAAIRSAYTLITGRELENLDIEPVRGLEGIKTASVNIDGLEVKVAVAHGLGNARHL
LDEIKEGVSPYHFIEIMACPGGCVGGGGQPIRFDSTLKKKRGEALYEEDRNMAKRCSHHNPSVEKIYKDYLEKPLGKRSH
KLLHTEYTSRPVV

Sequences:

>Translated_573_residues
MVTLNIDNKQISVPEGTTIMQAAKQANINIPHLCYFEGLKSYSGCRVCVVEIEGEPRLATSCSRKVAEGMKVNTHSARVR
RARRTILEILLANHPQDCFNCERNQNCDLLRLAFECGVKKLRFEESEKRVLPIDSTSPSIIRDPNKCIACGRCVRVCHDI
QTVNAIGFINKGPDTMVATSMDRGMGNVACANCGQCILVCPVGAIKERSAVDAVWAAIADPTKHVVVQEAPSVRVSLGEE
LGLPAGTLVAKKMYAALRRLGFDAVFDTNFTADLTIMEEGSELVERVKDGGVLPQITSCCPGWVKFMEHYYPELAPNVSS
AKSPQQMFGAVCKTYYAEKSGIDPKDIINVSVMPCTAKKFECQRPEMNDSGFKDVDYVLTTRELARMIKEAGLDFASLDE
EPAEDLLGLYTGAATIFGATGGVMEAAIRSAYTLITGRELENLDIEPVRGLEGIKTASVNIDGLEVKVAVAHGLGNARHL
LDEIKEGVSPYHFIEIMACPGGCVGGGGQPIRFDSTLKKKRGEALYEEDRNMAKRCSHHNPSVEKIYKDYLEKPLGKRSH
KLLHTEYTSRPVV
>Mature_573_residues
MVTLNIDNKQISVPEGTTIMQAAKQANINIPHLCYFEGLKSYSGCRVCVVEIEGEPRLATSCSRKVAEGMKVNTHSARVR
RARRTILEILLANHPQDCFNCERNQNCDLLRLAFECGVKKLRFEESEKRVLPIDSTSPSIIRDPNKCIACGRCVRVCHDI
QTVNAIGFINKGPDTMVATSMDRGMGNVACANCGQCILVCPVGAIKERSAVDAVWAAIADPTKHVVVQEAPSVRVSLGEE
LGLPAGTLVAKKMYAALRRLGFDAVFDTNFTADLTIMEEGSELVERVKDGGVLPQITSCCPGWVKFMEHYYPELAPNVSS
AKSPQQMFGAVCKTYYAEKSGIDPKDIINVSVMPCTAKKFECQRPEMNDSGFKDVDYVLTTRELARMIKEAGLDFASLDE
EPAEDLLGLYTGAATIFGATGGVMEAAIRSAYTLITGRELENLDIEPVRGLEGIKTASVNIDGLEVKVAVAHGLGNARHL
LDEIKEGVSPYHFIEIMACPGGCVGGGGQPIRFDSTLKKKRGEALYEEDRNMAKRCSHHNPSVEKIYKDYLEKPLGKRSH
KLLHTEYTSRPVV

Specific function: Ndh-1 Shuttles Electrons From NADH, Via Fmn And Iron- Sulfur (Fe-S) Centers, To Quinones In The Respiratory Chain. The Immediate Electron Acceptor For The Enzyme In This Species Is Believed To Be Ubiquinone. Couples The Redox Reaction To Proton Translocat

COG id: COG4624

COG function: function code R; Iron only hydrogenase large subunit, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI11968051, Length=399, Percent_Identity=30.0751879699248, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI6912524, Length=373, Percent_Identity=29.2225201072386, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI84452151, Length=373, Percent_Identity=29.2225201072386, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI134284357, Length=373, Percent_Identity=29.2225201072386, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI14165461, Length=414, Percent_Identity=28.2608695652174, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI33519475, Length=209, Percent_Identity=33.0143540669856, Blast_Score=134, Evalue=3e-31,
Organism=Escherichia coli, GI145693161, Length=216, Percent_Identity=26.3888888888889, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32566231, Length=248, Percent_Identity=31.8548387096774, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17565758, Length=248, Percent_Identity=31.8548387096774, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193209088, Length=243, Percent_Identity=31.2757201646091, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71995015, Length=403, Percent_Identity=29.7766749379653, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324089, Length=391, Percent_Identity=27.3657289002558, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI116007464, Length=343, Percent_Identity=29.7376093294461, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI116007468, Length=343, Percent_Identity=29.7376093294461, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI116007470, Length=343, Percent_Identity=29.7376093294461, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI116007466, Length=343, Percent_Identity=29.7376093294461, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24640559, Length=206, Percent_Identity=33.495145631068, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640557, Length=206, Percent_Identity=33.495145631068, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI116007462, Length=297, Percent_Identity=29.96632996633, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR009016
- InterPro:   IPR004108
- InterPro:   IPR003149
- InterPro:   IPR013352
- InterPro:   IPR001041 [H]

Pfam domain/function: PF02906 Fe_hyd_lg_C; PF02256 Fe_hyd_SSU [H]

EC number: =1.12.7.2 [H]

Molecular weight: Translated: 62798; Mature: 62798

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLNIDNKQISVPEGTTIMQAAKQANINIPHLCYFEGLKSYSGCRVCVVEIEGEPRLAT
CEEEEECCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHH
SCSRKVAEGMKVNTHSARVRRARRTILEILLANHPQDCFNCERNQNCDLLRLAFECGVKK
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHCHHH
LRFEESEKRVLPIDSTSPSIIRDPNKCIACGRCVRVCHDIQTVNAIGFINKGPDTMVATS
HCCCCCCCEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEH
MDRGMGNVACANCGQCILVCPVGAIKERSAVDAVWAAIADPTKHVVVQEAPSVRVSLGEE
HHCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCHH
LGLPAGTLVAKKMYAALRRLGFDAVFDTNFTADLTIMEEGSELVERVKDGGVLPQITSCC
HCCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCHHHHHHHHCCCCCCHHHHCC
PGWVKFMEHYYPELAPNVSSAKSPQQMFGAVCKTYYAEKSGIDPKDIINVSVMPCTAKKF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCCCCC
ECQRPEMNDSGFKDVDYVLTTRELARMIKEAGLDFASLDEEPAEDLLGLYTGAATIFGAT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCC
GGVMEAAIRSAYTLITGRELENLDIEPVRGLEGIKTASVNIDGLEVKVAVAHGLGNARHL
CHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEECCCCHHHHH
LDEIKEGVSPYHFIEIMACPGGCVGGGGQPIRFDSTLKKKRGEALYEEDRNMAKRCSHHN
HHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEECHHHHHHHCCHHHHHHHHHHHHHCCCC
PSVEKIYKDYLEKPLGKRSHKLLHTEYTSRPVV
CCHHHHHHHHHHCCCCHHHHHEEEECCCCCCCC
>Mature Secondary Structure
MVTLNIDNKQISVPEGTTIMQAAKQANINIPHLCYFEGLKSYSGCRVCVVEIEGEPRLAT
CEEEEECCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHH
SCSRKVAEGMKVNTHSARVRRARRTILEILLANHPQDCFNCERNQNCDLLRLAFECGVKK
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHCHHH
LRFEESEKRVLPIDSTSPSIIRDPNKCIACGRCVRVCHDIQTVNAIGFINKGPDTMVATS
HCCCCCCCEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEH
MDRGMGNVACANCGQCILVCPVGAIKERSAVDAVWAAIADPTKHVVVQEAPSVRVSLGEE
HHCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCHH
LGLPAGTLVAKKMYAALRRLGFDAVFDTNFTADLTIMEEGSELVERVKDGGVLPQITSCC
HCCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCHHHHHHHHCCCCCCHHHHCC
PGWVKFMEHYYPELAPNVSSAKSPQQMFGAVCKTYYAEKSGIDPKDIINVSVMPCTAKKF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCCCCC
ECQRPEMNDSGFKDVDYVLTTRELARMIKEAGLDFASLDEEPAEDLLGLYTGAATIFGAT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCC
GGVMEAAIRSAYTLITGRELENLDIEPVRGLEGIKTASVNIDGLEVKVAVAHGLGNARHL
CHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEECCCCHHHHH
LDEIKEGVSPYHFIEIMACPGGCVGGGGQPIRFDSTLKKKRGEALYEEDRNMAKRCSHHN
HHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEECHHHHHHHCCHHHHHHHHHHHHHCCCC
PSVEKIYKDYLEKPLGKRSHKLLHTEYTSRPVV
CCHHHHHHHHHHCCCCHHHHHEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1911757; 9836629; 10529166 [H]