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The map label for this gene is menA [H]

Identifier: 57234787

GI number: 57234787

Start: 380475

End: 381395

Strand: Direct

Name: menA [H]

Synonym: DET0401

Alternate gene names: 57234787

Gene position: 380475-381395 (Clockwise)

Preceding gene: 57234788

Following gene: 57234786

Centisome position: 25.89

GC content: 49.4

Gene sequence:

>921_bases
TTGAAAGCGCTTACTAGCGAACGTCCGGATTTTCAGGACTGGATACAGGCTGCCCGTCTCAAGTTCCTGCCCCAGGGTGT
AATGCCGGTGGTAATAGCCGGCGCTTTGGCTTTTTCTGAAGATACCTTTGACGTAGTCAACTTTGTAGTGGCCTTTTCAG
CCGCTGCCGCTGTTCAGATTGGCCTTACCATGTTTAATGACACCCTTGATTATGTTTATGGCACTGATTGCAAACATGCT
GATGCCAAAAACCCTTTTTCCGGCGGGAGCGGGGTTTTTACCTGTGGGGTTATAAAGCCCCGCCAGTCCCTCCTGGTTAT
CTTCTCTCTGTATTTCTTCGCCCTGCTGTGTGCCATTTATATGGCGCTGGATATGGGCTGGGGGGTTATGTGGATTGCCG
TTATCGGGGCGGCTATTTCCATACTCTATTCTGCTAAACCCATGCGTCTGGCTTACCATGGCCTGGGTGAGCTGATGATG
CTTATCGGTTACGGGCCGGTGCTGACAGCCTGGGGGTATTTTGTGCATACCGGTATGGTTAACCGGGATGTGCTGCTGAT
AGGTGTTATACCGGGTTTGTGCATGTGGGCAATGATACTTATAAATGAGATACCTGATTATCAGGAAGACCGGGCCGCCG
GTAAACGTAACCTGACTTATCGCCTGGGGCCTAAAAATGCCAAAAATCTTTTCAGTATCTCTTTGGCAGGCCTTTACACC
TATATACTGGCACTTGTATTTACCGGGGTGATGCCCCCGCTTTCAGCCATATCCTTAGGCGGTATCCCTCTGGCAGTTAT
GGCTGTCAGGATTGCCCACCGCTATTATAATGACCCCATAAAGGTAGCCATGGCCAATAAATTGATGGTCATAATATATT
CGGTCACAACTGCTACGGTGGCCATAGGGATGTTGACATAA

Upstream 100 bases:

>100_bases
GCCCGTACAGACTTCTTTTTGCTTGAGGATTTTACCCGTTTCCACAAGGAAAATGGTAAAATAGGTACCAAGGTTTCTGA
AGAGGTTTTGAAGAAAGTTC

Downstream 100 bases:

>100_bases
TGGTAGCCCCCAGTTTTTTTGAAAAAGTTGCCCCGGTATACGAATTTTTAACCCGTATGTTTATGCTGGGTACATTTGAA
AGTGCCCGTGACAGAATGCT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase, putative

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKALTSERPDFQDWIQAARLKFLPQGVMPVVIAGALAFSEDTFDVVNFVVAFSAAAAVQIGLTMFNDTLDYVYGTDCKHA
DAKNPFSGGSGVFTCGVIKPRQSLLVIFSLYFFALLCAIYMALDMGWGVMWIAVIGAAISILYSAKPMRLAYHGLGELMM
LIGYGPVLTAWGYFVHTGMVNRDVLLIGVIPGLCMWAMILINEIPDYQEDRAAGKRNLTYRLGPKNAKNLFSISLAGLYT
YILALVFTGVMPPLSAISLGGIPLAVMAVRIAHRYYNDPIKVAMANKLMVIIYSVTTATVAIGMLT

Sequences:

>Translated_306_residues
MKALTSERPDFQDWIQAARLKFLPQGVMPVVIAGALAFSEDTFDVVNFVVAFSAAAAVQIGLTMFNDTLDYVYGTDCKHA
DAKNPFSGGSGVFTCGVIKPRQSLLVIFSLYFFALLCAIYMALDMGWGVMWIAVIGAAISILYSAKPMRLAYHGLGELMM
LIGYGPVLTAWGYFVHTGMVNRDVLLIGVIPGLCMWAMILINEIPDYQEDRAAGKRNLTYRLGPKNAKNLFSISLAGLYT
YILALVFTGVMPPLSAISLGGIPLAVMAVRIAHRYYNDPIKVAMANKLMVIIYSVTTATVAIGMLT
>Mature_306_residues
MKALTSERPDFQDWIQAARLKFLPQGVMPVVIAGALAFSEDTFDVVNFVVAFSAAAAVQIGLTMFNDTLDYVYGTDCKHA
DAKNPFSGGSGVFTCGVIKPRQSLLVIFSLYFFALLCAIYMALDMGWGVMWIAVIGAAISILYSAKPMRLAYHGLGELMM
LIGYGPVLTAWGYFVHTGMVNRDVLLIGVIPGLCMWAMILINEIPDYQEDRAAGKRNLTYRLGPKNAKNLFSISLAGLYT
YILALVFTGVMPPLSAISLGGIPLAVMAVRIAHRYYNDPIKVAMANKLMVIIYSVTTATVAIGMLT

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=233, Percent_Identity=29.1845493562232, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33310; Mature: 33310

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTSERPDFQDWIQAARLKFLPQGVMPVVIAGALAFSEDTFDVVNFVVAFSAAAAVQI
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLTMFNDTLDYVYGTDCKHADAKNPFSGGSGVFTCGVIKPRQSLLVIFSLYFFALLCAIY
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
MALDMGWGVMWIAVIGAAISILYSAKPMRLAYHGLGELMMLIGYGPVLTAWGYFVHTGMV
HHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
NRDVLLIGVIPGLCMWAMILINEIPDYQEDRAAGKRNLTYRLGPKNAKNLFSISLAGLYT
CCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
YILALVFTGVMPPLSAISLGGIPLAVMAVRIAHRYYNDPIKVAMANKLMVIIYSVTTATV
HHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHHHH
AIGMLT
HHHCCC
>Mature Secondary Structure
MKALTSERPDFQDWIQAARLKFLPQGVMPVVIAGALAFSEDTFDVVNFVVAFSAAAAVQI
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLTMFNDTLDYVYGTDCKHADAKNPFSGGSGVFTCGVIKPRQSLLVIFSLYFFALLCAIY
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
MALDMGWGVMWIAVIGAAISILYSAKPMRLAYHGLGELMMLIGYGPVLTAWGYFVHTGMV
HHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
NRDVLLIGVIPGLCMWAMILINEIPDYQEDRAAGKRNLTYRLGPKNAKNLFSISLAGLYT
CCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
YILALVFTGVMPPLSAISLGGIPLAVMAVRIAHRYYNDPIKVAMANKLMVIIYSVTTATV
HHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHHHH
AIGMLT
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]