Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 57234734

GI number: 57234734

Start: 423507

End: 425057

Strand: Direct

Name: pccB [H]

Synonym: DET0447

Alternate gene names: 57234734

Gene position: 423507-425057 (Clockwise)

Preceding gene: 57234759

Following gene: 57234733

Centisome position: 28.82

GC content: 51.84

Gene sequence:

>1551_bases
GTGGCTGTACAGGAACAACTGGATAACCTGAACCGTCTTAAAAAACAGGCGGAAATGGGTGGCGGGGAAGCCAAGATAGA
TGCTCAGCATAAACGGGGCAAGTTAACTGCCCGTGAACGTATAGATTTGCTCTTTGACAAAGGAACATTTAACGAACTGG
GGGCTTTTGCTGCCCACCGCTGCCGTGATTTCGGGCTGGAAAAACAGCGGAATGCGGGGGATGCGGTGGTAACCGGCAGC
GGTCTGGTGAACGGACGGCTGGTTTTTGCCTACTCACAGGATTTTACTGTCCTAGGCGGCTCTATCTCCGAAGTGGTAGG
CCAGAAAGTAGCCCAGGTTATAGATATGGCTATCAGGGCGGGTGCGCCCCTTATTGCCATAAATGACTCAGGCGGTGCCC
GTATACAGGAGGGGGTTGCCAGTCTGAGCGGGGTGGGGGATATACTCCTTAGGAATACCATTGCCAGCGGGGTTATTCCC
CAGATATCGGTAGTGGTAGGCCCAAGTGCCGGGGGGGCGGTTTATGCCCCGGCTCTGACAGACTTTATCTTTGCGGTTAA
GGGCATAAGCCAGATGTATATTACCGGGCCGGATGTTATCAAAGCGGTCACCGGTGAAGATATCAGCCATGAGGCGCTGG
GGGGAGCGGAAATCCACGCTAAGAAAAGCGGGGTAGCCCATTTCCTGTGCGAAAATGAAAAGGAGTGTTTTGAGCAAATA
AGGGAGCTGATGGGTTTCCTGCCCCAGAGCAACCGCCACAAACCTCCCCGCGGCAAAAACAAGGATAATGAAGAACGCAA
AACCCGTGACCTCAGGGATATTATACCGGATAATCCCAAACGGGCTTACGATATGAAAAAAGTGATTACCGAAGTAGCGG
ACGAGAAGGAGTTTTTTGAGGTTCACAAGCATTTTGCCCAGAATATAATAGTCGGCTTTGTGAGGATGGGCGGGCAGCCT
GCGGGTATTGTCGCCCAGCAGCCTTCGCATATGGCCGGGGTTATAGATATAAATGCATCACTCAAAGCAGCCCGGTTTAT
CCGCTTTTGTGATGCATTTGAGATACCGCTGGTAAGTTTTGTAGACGTGCCGGGTTTTATGCCGGGTACAGACCAGGAGC
ACAGCGGTATTATCAAGCACGGTGCCAAGCTGATTTATGCTTATGCGGAAGCAACTGTGCCCAAGATAACGGTTATCACC
CGCAAGGCTTACGGGGGTGCGTATATTGTTATGAGCAGCAAGCACCTCAGGGGGGATATAAACTATGCCTGGCCGGCCAG
TGAAGTGGCGGTCATGGGGGCGGAAGGGGCGGTAAATATCATATCCCGCAAAGCTATAGCTGAGGCAGCTAATCCCGAAG
AAACCCGCCAGAAACTGCTTGACGAATACCGGGAACACTTTGCCAACCCCTATCAGGCGGCTCAGCTGGGCTATATAGAC
GACGTAATTGACCCGGCGGATACCAGAAGCAAAATAATAAAAGCCCTGCGCTCTCTGGAAAACAAGGTGCTGGCAAATCC
TCCTAAGAAACACGGGAATATACCTTTGTAA

Upstream 100 bases:

>100_bases
GCAGTTTGCACCTGTATCTACGTACAATGCAAACGTGAGTTAAGTTGCCCTTGGTAGTGGGCTGTGTTATCATTACGGGA
GTTTTGGGTGGAGGAAGTGC

Downstream 100 bases:

>100_bases
AGGAAGGTTGCATAAACAAAACATGGGGAAAACACTAGCAGAAAAAATACTCAGCCTGAAGTCTGGCAGTGATGCCAGCG
CCGGAGACATAGTAGTCTCC

Product: acyl CoA biotin-dependant carboxyltransferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MAVQEQLDNLNRLKKQAEMGGGEAKIDAQHKRGKLTARERIDLLFDKGTFNELGAFAAHRCRDFGLEKQRNAGDAVVTGS
GLVNGRLVFAYSQDFTVLGGSISEVVGQKVAQVIDMAIRAGAPLIAINDSGGARIQEGVASLSGVGDILLRNTIASGVIP
QISVVVGPSAGGAVYAPALTDFIFAVKGISQMYITGPDVIKAVTGEDISHEALGGAEIHAKKSGVAHFLCENEKECFEQI
RELMGFLPQSNRHKPPRGKNKDNEERKTRDLRDIIPDNPKRAYDMKKVITEVADEKEFFEVHKHFAQNIIVGFVRMGGQP
AGIVAQQPSHMAGVIDINASLKAARFIRFCDAFEIPLVSFVDVPGFMPGTDQEHSGIIKHGAKLIYAYAEATVPKITVIT
RKAYGGAYIVMSSKHLRGDINYAWPASEVAVMGAEGAVNIISRKAIAEAANPEETRQKLLDEYREHFANPYQAAQLGYID
DVIDPADTRSKIIKALRSLENKVLANPPKKHGNIPL

Sequences:

>Translated_516_residues
MAVQEQLDNLNRLKKQAEMGGGEAKIDAQHKRGKLTARERIDLLFDKGTFNELGAFAAHRCRDFGLEKQRNAGDAVVTGS
GLVNGRLVFAYSQDFTVLGGSISEVVGQKVAQVIDMAIRAGAPLIAINDSGGARIQEGVASLSGVGDILLRNTIASGVIP
QISVVVGPSAGGAVYAPALTDFIFAVKGISQMYITGPDVIKAVTGEDISHEALGGAEIHAKKSGVAHFLCENEKECFEQI
RELMGFLPQSNRHKPPRGKNKDNEERKTRDLRDIIPDNPKRAYDMKKVITEVADEKEFFEVHKHFAQNIIVGFVRMGGQP
AGIVAQQPSHMAGVIDINASLKAARFIRFCDAFEIPLVSFVDVPGFMPGTDQEHSGIIKHGAKLIYAYAEATVPKITVIT
RKAYGGAYIVMSSKHLRGDINYAWPASEVAVMGAEGAVNIISRKAIAEAANPEETRQKLLDEYREHFANPYQAAQLGYID
DVIDPADTRSKIIKALRSLENKVLANPPKKHGNIPL
>Mature_515_residues
AVQEQLDNLNRLKKQAEMGGGEAKIDAQHKRGKLTARERIDLLFDKGTFNELGAFAAHRCRDFGLEKQRNAGDAVVTGSG
LVNGRLVFAYSQDFTVLGGSISEVVGQKVAQVIDMAIRAGAPLIAINDSGGARIQEGVASLSGVGDILLRNTIASGVIPQ
ISVVVGPSAGGAVYAPALTDFIFAVKGISQMYITGPDVIKAVTGEDISHEALGGAEIHAKKSGVAHFLCENEKECFEQIR
ELMGFLPQSNRHKPPRGKNKDNEERKTRDLRDIIPDNPKRAYDMKKVITEVADEKEFFEVHKHFAQNIIVGFVRMGGQPA
GIVAQQPSHMAGVIDINASLKAARFIRFCDAFEIPLVSFVDVPGFMPGTDQEHSGIIKHGAKLIYAYAEATVPKITVITR
KAYGGAYIVMSSKHLRGDINYAWPASEVAVMGAEGAVNIISRKAIAEAANPEETRQKLLDEYREHFANPYQAAQLGYIDD
VIDPADTRSKIIKALRSLENKVLANPPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=517, Percent_Identity=55.705996131528, Blast_Score=590, Evalue=1e-168,
Organism=Homo sapiens, GI295821216, Length=537, Percent_Identity=53.6312849162011, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI11545863, Length=499, Percent_Identity=31.6633266533066, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679974, Length=340, Percent_Identity=24.7058823529412, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679977, Length=340, Percent_Identity=24.7058823529412, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679967, Length=340, Percent_Identity=24.7058823529412, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679960, Length=340, Percent_Identity=24.7058823529412, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679971, Length=340, Percent_Identity=24.7058823529412, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI134142062, Length=345, Percent_Identity=24.3478260869565, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=55.0295857988166, Blast_Score=593, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=55.0295857988166, Blast_Score=592, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17552936, Length=519, Percent_Identity=33.3333333333333, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71997163, Length=398, Percent_Identity=24.1206030150754, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24586065, Length=522, Percent_Identity=33.1417624521073, Blast_Score=241, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55985; Mature: 55854

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQEQLDNLNRLKKQAEMGGGEAKIDAQHKRGKLTARERIDLLFDKGTFNELGAFAAHR
CCHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCHHHHHHHEECCCCHHHHHHHHHHH
CRDFGLEKQRNAGDAVVTGSGLVNGRLVFAYSQDFTVLGGSISEVVGQKVAQVIDMAIRA
HHHCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHC
GAPLIAINDSGGARIQEGVASLSGVGDILLRNTIASGVIPQISVVVGPSAGGAVYAPALT
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHH
DFIFAVKGISQMYITGPDVIKAVTGEDISHEALGGAEIHAKKSGVAHFLCENEKECFEQI
HHHHHHHCCHHEEECCHHHHHHHCCCCCCHHHCCCCEEEECCCCCHHHHCCCHHHHHHHH
RELMGFLPQSNRHKPPRGKNKDNEERKTRDLRDIIPDNPKRAYDMKKVITEVADEKEFFE
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHH
VHKHFAQNIIVGFVRMGGQPAGIVAQQPSHMAGVIDINASLKAARFIRFCDAFEIPLVSF
HHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHH
VDVPGFMPGTDQEHSGIIKHGAKLIYAYAEATVPKITVITRKAYGGAYIVMSSKHLRGDI
CCCCCCCCCCCCCCCCHHHHCHHEEEEEHHCCCCEEEEEEEECCCCEEEEEECHHCCCCC
NYAWPASEVAVMGAEGAVNIISRKAIAEAANPEETRQKLLDEYREHFANPYQAAQLGYID
CCCCCCHHEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCHH
DVIDPADTRSKIIKALRSLENKVLANPPKKHGNIPL
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AVQEQLDNLNRLKKQAEMGGGEAKIDAQHKRGKLTARERIDLLFDKGTFNELGAFAAHR
CHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCHHHHHHHEECCCCHHHHHHHHHHH
CRDFGLEKQRNAGDAVVTGSGLVNGRLVFAYSQDFTVLGGSISEVVGQKVAQVIDMAIRA
HHHCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHC
GAPLIAINDSGGARIQEGVASLSGVGDILLRNTIASGVIPQISVVVGPSAGGAVYAPALT
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHH
DFIFAVKGISQMYITGPDVIKAVTGEDISHEALGGAEIHAKKSGVAHFLCENEKECFEQI
HHHHHHHCCHHEEECCHHHHHHHCCCCCCHHHCCCCEEEECCCCCHHHHCCCHHHHHHHH
RELMGFLPQSNRHKPPRGKNKDNEERKTRDLRDIIPDNPKRAYDMKKVITEVADEKEFFE
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHH
VHKHFAQNIIVGFVRMGGQPAGIVAQQPSHMAGVIDINASLKAARFIRFCDAFEIPLVSF
HHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHH
VDVPGFMPGTDQEHSGIIKHGAKLIYAYAEATVPKITVITRKAYGGAYIVMSSKHLRGDI
CCCCCCCCCCCCCCCCHHHHCHHEEEEEHHCCCCEEEEEEEECCCCEEEEEECHHCCCCC
NYAWPASEVAVMGAEGAVNIISRKAIAEAANPEETRQKLLDEYREHFANPYQAAQLGYID
CCCCCCHHEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCHH
DVIDPADTRSKIIKALRSLENKVLANPPKKHGNIPL
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]