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The map label for this gene is mnhA1 [H]

Identifier: 57234361

GI number: 57234361

Start: 787934

End: 789880

Strand: Direct

Name: mnhA1 [H]

Synonym: DET0860

Alternate gene names: 57234361

Gene position: 787934-789880 (Clockwise)

Preceding gene: 57234362

Following gene: 57234360

Centisome position: 53.61

GC content: 47.25

Gene sequence:

>1947_bases
TTGGCCAGTAGTCTTATTGCTATAGCCGTTCTCTTCCCATTTACCGCCGGCTTGGTTTGCCTTTTTCTGAAAAATACCCT
TCTCCGGTCCGGGCTGGTTGCTCTGTCAGCTATTGTACTCATCTGCAGTTCCATTTTGCTGTTTTCCCAGGGAAATTTGC
CCATTGAATACAGCCCCGCCCACCAGTGGGACAGTGTTATTCTGGTGCTGGATTATGCTTTGCTGGTATTTTTCCTGTTT
GTGGGTGTGAAAGATATCCTTAAAAACGGCTGGAGTGCCAGAGGTGTTTTAACCTCCGGGCTGGTGCTTTCCCAGATAAT
TCTCCTGGGCCTGTTTGAGTTTGTCTGGGCACCCTCCGTACCGCTTGCGTCCGAACCGGCTTTCTTTATTGACCAGCTTT
CGATAATAATGTGCCTCATTATTTCCATTATCGGTTCGCTTATACTTCTTTACGCCATCAAATACATGAAAGACCATGAG
CATCACCAGCACCTAAGCGTCACCCGCCAGCCCCGTTTCTTCTTCTTTATGACCATACTGCTGGGTGCTATGAACGGCAT
TGTCTTTTCTGATAACCTCCTCTGGATATACTTTTTCTGGGAAATAACCACTTTATGCTGCTTTGCCCTGATTGGCCATG
AACAAACCAAGGAAGCCATCAACAATGCTTTTAGGGCTTTGTGGATGAATCTGATAGGCGGTCTGGGATTTGTACTGGCT
ATTATTTATGTCTTTACAAATTATGACAGTATTTCCCTGCAGGCTCTTATAACTAACCCGGCCGTAGCCATGGCGCCACT
CTTCTTCCTGTTTATGGCGGCTTTTACCAAATCAGCCCAGGTGCCGTTTCAGGGCTGGCTTCTGGGGGCAATGGTGGCAC
CCGTACCTGTTTCCGCCCTGCTTCATTCCTCCACTATGGTAAAAGCGGGTATTTACCTTTCTATCCGGCTGGCACCGGCT
ATTACTGATACATCTTTAGCTACGTTAATTGCCCTGTTCGGGGCATTTACTTTTATGGTTACCGCCATTATGGCCATCAG
CCAGCGTGAATCCAAGAAAGTTTTAGCCTACTCCACCATCTCAAACCTGGGGCTTATTATTATGTGTGTGGGTATAAATA
CCCCTTTGGCAATTACTGCTGCCATTGTGCTCACCATTTTTCATGCCATATCAAAAGCCTTGCTCTTTATGTGCGTGGGT
GTCATAGACCACTCTTTGGGCAGCCGTGATATTGAAAACATGGAGGGGCTGGTACGCCGTTACCCTTTAATTGCCGGTAT
AACTATAGCCGGTATTCTCTCCATGATGCTGGTGCCTTTCGGTATGCTGCTGGGCAAATGGGCGGCTATAGAGGCCACTT
CAGCTATGTCCGGGTTTATCTCACCCCTGGTGTTCCTGCTGCTGATTATAGGCTCGGCAGCTACTACCGTTTTCTGGGTA
AAATGGCTGGGCCGCTTTTTCAGCGTAACGCCGGGTATAGAAAAAATACGTTTTGAGCGTTTTTCATTTTTATACCACGC
CCCTTTGATTGTACTGCTGGCTTTTGCCGGAGTGTTCAGTATAGGGGTGATACCCTTCTATGAAAGCTTTATTTTACCGG
CGGTAACTGCTTTCTATCCGAATGCCATTGACACTTCAAACGGATTTTTCGGCAGTGCGGCCGGGTTATTTACTGTGTGG
CCGCTGTTTATCCTGCTGGCCATAGCCATTATACTGGTGCCGGTTTTATTTAAGCCTAAAACCAAAAACCTCAGCACTGC
CTATATGTGCGGTGAAAATGTCAGCACCTCAGCGGACAGTTTTTATTCGGTGGCTGACGGTGAAACTAAACTAAAGCTGG
GGTCTATGTATCTTGACACCCAGTTTGCCAACCCCCATCTGGATACCGGGCTAAAAATAGCTGGCCTTTTGATACTGGTT
AGTATGCTGGTAGTGGTGCTGATATGA

Upstream 100 bases:

>100_bases
CAATACCGCCACTTAAGCTACTTTTGGGTATTCTATTGTCTTTTGCATACGTATGTCTTTATGCCCGGGGTAGACATTAC
TAAAAAAGGAAGATTAGATT

Downstream 100 bases:

>100_bases
ATGAATGGTTGCTGGTTGCCTTAGCTCTGGTTTTACCCCCGGTACTGGGCAGTTTGCTCCGCGGTCTTGACCGCATACTG
ACAGCCCGAATGCAGGGCAG

Product: hydrogenase, EchA subunit, putative

Products: NA

Alternate protein names: Mnh complex subunit A1 [H]

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MASSLIAIAVLFPFTAGLVCLFLKNTLLRSGLVALSAIVLICSSILLFSQGNLPIEYSPAHQWDSVILVLDYALLVFFLF
VGVKDILKNGWSARGVLTSGLVLSQIILLGLFEFVWAPSVPLASEPAFFIDQLSIIMCLIISIIGSLILLYAIKYMKDHE
HHQHLSVTRQPRFFFFMTILLGAMNGIVFSDNLLWIYFFWEITTLCCFALIGHEQTKEAINNAFRALWMNLIGGLGFVLA
IIYVFTNYDSISLQALITNPAVAMAPLFFLFMAAFTKSAQVPFQGWLLGAMVAPVPVSALLHSSTMVKAGIYLSIRLAPA
ITDTSLATLIALFGAFTFMVTAIMAISQRESKKVLAYSTISNLGLIIMCVGINTPLAITAAIVLTIFHAISKALLFMCVG
VIDHSLGSRDIENMEGLVRRYPLIAGITIAGILSMMLVPFGMLLGKWAAIEATSAMSGFISPLVFLLLIIGSAATTVFWV
KWLGRFFSVTPGIEKIRFERFSFLYHAPLIVLLAFAGVFSIGVIPFYESFILPAVTAFYPNAIDTSNGFFGSAAGLFTVW
PLFILLAIAIILVPVLFKPKTKNLSTAYMCGENVSTSADSFYSVADGETKLKLGSMYLDTQFANPHLDTGLKIAGLLILV
SMLVVVLI

Sequences:

>Translated_648_residues
MASSLIAIAVLFPFTAGLVCLFLKNTLLRSGLVALSAIVLICSSILLFSQGNLPIEYSPAHQWDSVILVLDYALLVFFLF
VGVKDILKNGWSARGVLTSGLVLSQIILLGLFEFVWAPSVPLASEPAFFIDQLSIIMCLIISIIGSLILLYAIKYMKDHE
HHQHLSVTRQPRFFFFMTILLGAMNGIVFSDNLLWIYFFWEITTLCCFALIGHEQTKEAINNAFRALWMNLIGGLGFVLA
IIYVFTNYDSISLQALITNPAVAMAPLFFLFMAAFTKSAQVPFQGWLLGAMVAPVPVSALLHSSTMVKAGIYLSIRLAPA
ITDTSLATLIALFGAFTFMVTAIMAISQRESKKVLAYSTISNLGLIIMCVGINTPLAITAAIVLTIFHAISKALLFMCVG
VIDHSLGSRDIENMEGLVRRYPLIAGITIAGILSMMLVPFGMLLGKWAAIEATSAMSGFISPLVFLLLIIGSAATTVFWV
KWLGRFFSVTPGIEKIRFERFSFLYHAPLIVLLAFAGVFSIGVIPFYESFILPAVTAFYPNAIDTSNGFFGSAAGLFTVW
PLFILLAIAIILVPVLFKPKTKNLSTAYMCGENVSTSADSFYSVADGETKLKLGSMYLDTQFANPHLDTGLKIAGLLILV
SMLVVVLI
>Mature_647_residues
ASSLIAIAVLFPFTAGLVCLFLKNTLLRSGLVALSAIVLICSSILLFSQGNLPIEYSPAHQWDSVILVLDYALLVFFLFV
GVKDILKNGWSARGVLTSGLVLSQIILLGLFEFVWAPSVPLASEPAFFIDQLSIIMCLIISIIGSLILLYAIKYMKDHEH
HQHLSVTRQPRFFFFMTILLGAMNGIVFSDNLLWIYFFWEITTLCCFALIGHEQTKEAINNAFRALWMNLIGGLGFVLAI
IYVFTNYDSISLQALITNPAVAMAPLFFLFMAAFTKSAQVPFQGWLLGAMVAPVPVSALLHSSTMVKAGIYLSIRLAPAI
TDTSLATLIALFGAFTFMVTAIMAISQRESKKVLAYSTISNLGLIIMCVGINTPLAITAAIVLTIFHAISKALLFMCVGV
IDHSLGSRDIENMEGLVRRYPLIAGITIAGILSMMLVPFGMLLGKWAAIEATSAMSGFISPLVFLLLIIGSAATTVFWVK
WLGRFFSVTPGIEKIRFERFSFLYHAPLIVLLAFAGVFSIGVIPFYESFILPAVTAFYPNAIDTSNGFFGSAAGLFTVWP
LFILLAIAIILVPVLFKPKTKNLSTAYMCGENVSTSADSFYSVADGETKLKLGSMYLDTQFANPHLDTGLKIAGLLILVS
MLVVVLI

Specific function: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion [H]

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=273, Percent_Identity=38.4615384615385, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1788829, Length=376, Percent_Identity=31.9148936170213, Blast_Score=166, Evalue=6e-42,
Organism=Escherichia coli, GI1788614, Length=433, Percent_Identity=29.7921478060046, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788831, Length=342, Percent_Identity=28.3625730994152, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788827, Length=330, Percent_Identity=27.5757575757576, Blast_Score=106, Evalue=6e-24,
Organism=Escherichia coli, GI1788613, Length=326, Percent_Identity=24.2331288343558, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI2367154, Length=503, Percent_Identity=23.2604373757455, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005663
- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 70672; Mature: 70540

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSLIAIAVLFPFTAGLVCLFLKNTLLRSGLVALSAIVLICSSILLFSQGNLPIEYSPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
HQWDSVILVLDYALLVFFLFVGVKDILKNGWSARGVLTSGLVLSQIILLGLFEFVWAPSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PLASEPAFFIDQLSIIMCLIISIIGSLILLYAIKYMKDHEHHQHLSVTRQPRFFFFMTIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHH
LGAMNGIVFSDNLLWIYFFWEITTLCCFALIGHEQTKEAINNAFRALWMNLIGGLGFVLA
HHHHCCEEEECCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIYVFTNYDSISLQALITNPAVAMAPLFFLFMAAFTKSAQVPFQGWLLGAMVAPVPVSAL
HHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHH
LHSSTMVKAGIYLSIRLAPAITDTSLATLIALFGAFTFMVTAIMAISQRESKKVLAYSTI
HHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHH
SNLGLIIMCVGINTPLAITAAIVLTIFHAISKALLFMCVGVIDHSLGSRDIENMEGLVRR
HCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
YPLIAGITIAGILSMMLVPFGMLLGKWAAIEATSAMSGFISPLVFLLLIIGSAATTVFWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWLGRFFSVTPGIEKIRFERFSFLYHAPLIVLLAFAGVFSIGVIPFYESFILPAVTAFYP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NAIDTSNGFFGSAAGLFTVWPLFILLAIAIILVPVLFKPKTKNLSTAYMCGENVSTSADS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHH
FYSVADGETKLKLGSMYLDTQFANPHLDTGLKIAGLLILVSMLVVVLI
HEEECCCCCEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
ASSLIAIAVLFPFTAGLVCLFLKNTLLRSGLVALSAIVLICSSILLFSQGNLPIEYSPA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
HQWDSVILVLDYALLVFFLFVGVKDILKNGWSARGVLTSGLVLSQIILLGLFEFVWAPSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PLASEPAFFIDQLSIIMCLIISIIGSLILLYAIKYMKDHEHHQHLSVTRQPRFFFFMTIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHH
LGAMNGIVFSDNLLWIYFFWEITTLCCFALIGHEQTKEAINNAFRALWMNLIGGLGFVLA
HHHHCCEEEECCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIYVFTNYDSISLQALITNPAVAMAPLFFLFMAAFTKSAQVPFQGWLLGAMVAPVPVSAL
HHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHH
LHSSTMVKAGIYLSIRLAPAITDTSLATLIALFGAFTFMVTAIMAISQRESKKVLAYSTI
HHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHH
SNLGLIIMCVGINTPLAITAAIVLTIFHAISKALLFMCVGVIDHSLGSRDIENMEGLVRR
HCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
YPLIAGITIAGILSMMLVPFGMLLGKWAAIEATSAMSGFISPLVFLLLIIGSAATTVFWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWLGRFFSVTPGIEKIRFERFSFLYHAPLIVLLAFAGVFSIGVIPFYESFILPAVTAFYP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NAIDTSNGFFGSAAGLFTVWPLFILLAIAIILVPVLFKPKTKNLSTAYMCGENVSTSADS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHH
FYSVADGETKLKLGSMYLDTQFANPHLDTGLKIAGLLILVSMLVVVLI
HEEECCCCCEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA