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The map label for this gene is ndhD1 [H]

Identifier: 57234290

GI number: 57234290

Start: 852516

End: 854009

Strand: Direct

Name: ndhD1 [H]

Synonym: DET0932

Alternate gene names: 57234290

Gene position: 852516-854009 (Clockwise)

Preceding gene: 57234291

Following gene: 57234289

Centisome position: 58.01

GC content: 49.06

Gene sequence:

>1494_bases
ATGAGCATACCATACTTAACACTAATAACTTTCCTGCCCGCAGCGGGAGCTATCTTGATGGCTCTGTGGCCGCGTTTGTC
CGGGCGGGCAATAAAAATCAGCTCACTGCTGCTCACTCTTGTGCCGCTGGTGCTCTCACTAGTGGTCTTTGCCGGATTTG
ACCGGAGTAGTTCCATGGCCGGGGTTATACAGTTTGAAGAAAATCTCCCCTGGATATCCCTTTTAAACGCTAACTACCAC
CTTGGCGTTGACGGTTTAAGTTTGCCTTTCCTGGTTCTGACTACTTTACTGGGTGTTCTGGCGGTACTTATCAGCTGGAA
AGTAGACCTCAGGATAAAAGAGTTTTTTGTCTGGCTGCTTATACTCCAAACCAGCATTACAGGCGTATTTGTCTCTCTTG
ATTTGCTGCTCTTCTTTATCTTCTGGGAGCTGGAACTGATACCCATGTATTTCCTGATTTCAATCTGGGGTGCCGGGCGT
AAAGAGTATTCGGCTCTTAAATACGTCCTTTACACCCTGTTTGGCGGTGCGTTTATACTGGCCGGTATCCTGATACTTTT
CTTTGCCACCGGCAGTCTGGATATAGCGTCTCTGGCATCTACGGACCTAAATAATTTCCTGCGTCCGGCCATGATGGTGC
TTACTTTCTTTATGTTTTTTATCGGTTTTGCCATCAAGCTTCCGGCTTTCCCCTTCCACACCTGGCTGCCGGATGCCCAT
ACAGACGCACCTACCGCCGCCAGTGTTATTCTGGCAGGTACGTTGCTTAAAATGGGCGGCTATGCCATGCTCAGGTTAAA
CGTGGCCATGTTCCCTGACGTCTGCCGTGACTGGGCGCCTTTGATACTGACTATTGCGGTCATAAACGTAATTTACGGTG
CCGCTATCACCCTTAAACAAACAGATATCAAAAGGCTTATTGCCTACAGTTCGGTAAGCCACATGGGTTTTGTACTGCTG
GGTATATTTACCCTGGGTGAAATCTCCATGAACGGTGCGGTTCTGCAAATGTTCAGCCACGGTATAATCACCGGTCTGCT
CTTTGCCATAACCGGTGTAGTTATGCACAATACCCACGAACGGGATATTAACAAGCTGGGCGGTCTGGCAAAACAGATGC
CCCGCACAGCTATCATATTTATACTGGCCGGTCTGGGGGCGATGGCTGTGCCGGCTACCAGCGGGTTTATCGCCGAAGTC
AGCGTATTTTTAGGTTCATTCCAGAGTTCGGTAGTCCCCGGCGGGCAGGTATTTACCATGCTCTGCCTTTTGGGTTTGGT
ACTGGCAGCTGCCTATATACTCTGGACAGTCCAGAGGGTATTTTTGGGCCCCGGACTGGAAAAATTCCAGATGGTAAAAG
ATGCCGATAAAACCGAAATAGTTTTTTCACTGGTATTTTTAGTGGTAATGTTCGGGGTTGGCCTTTATCCCCAGATTATA
GTAGATGTGATTCAAACCGGAGTGGCCCCGCTGGCGGCCGTTTTCGGCGGATAG

Upstream 100 bases:

>100_bases
CAAAGCCCAGACCGGGCAGCTCCAATCATACGGAATTTATCTTGCCGCCGGGGTGGTTGTACTGGTGATGGCGGCTCTTA
TTATCTGGTAAGGGGGGAGT

Downstream 100 bases:

>100_bases
AGGCAGATGGATTTGTTTATGCCTGAAATAATAATACTGATAACAGCCATTTTGGTTATAATAACTGACCTCTTTCTGAC
TAAAAGCAAGAGGTATCTGG

Product: proton-translocating NADH-quinone oxidoreductase, M subunit

Products: NAD+; ubiquinol [C]

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSIPYLTLITFLPAAGAILMALWPRLSGRAIKISSLLLTLVPLVLSLVVFAGFDRSSSMAGVIQFEENLPWISLLNANYH
LGVDGLSLPFLVLTTLLGVLAVLISWKVDLRIKEFFVWLLILQTSITGVFVSLDLLLFFIFWELELIPMYFLISIWGAGR
KEYSALKYVLYTLFGGAFILAGILILFFATGSLDIASLASTDLNNFLRPAMMVLTFFMFFIGFAIKLPAFPFHTWLPDAH
TDAPTAASVILAGTLLKMGGYAMLRLNVAMFPDVCRDWAPLILTIAVINVIYGAAITLKQTDIKRLIAYSSVSHMGFVLL
GIFTLGEISMNGAVLQMFSHGIITGLLFAITGVVMHNTHERDINKLGGLAKQMPRTAIIFILAGLGAMAVPATSGFIAEV
SVFLGSFQSSVVPGGQVFTMLCLLGLVLAAAYILWTVQRVFLGPGLEKFQMVKDADKTEIVFSLVFLVVMFGVGLYPQII
VDVIQTGVAPLAAVFGG

Sequences:

>Translated_497_residues
MSIPYLTLITFLPAAGAILMALWPRLSGRAIKISSLLLTLVPLVLSLVVFAGFDRSSSMAGVIQFEENLPWISLLNANYH
LGVDGLSLPFLVLTTLLGVLAVLISWKVDLRIKEFFVWLLILQTSITGVFVSLDLLLFFIFWELELIPMYFLISIWGAGR
KEYSALKYVLYTLFGGAFILAGILILFFATGSLDIASLASTDLNNFLRPAMMVLTFFMFFIGFAIKLPAFPFHTWLPDAH
TDAPTAASVILAGTLLKMGGYAMLRLNVAMFPDVCRDWAPLILTIAVINVIYGAAITLKQTDIKRLIAYSSVSHMGFVLL
GIFTLGEISMNGAVLQMFSHGIITGLLFAITGVVMHNTHERDINKLGGLAKQMPRTAIIFILAGLGAMAVPATSGFIAEV
SVFLGSFQSSVVPGGQVFTMLCLLGLVLAAAYILWTVQRVFLGPGLEKFQMVKDADKTEIVFSLVFLVVMFGVGLYPQII
VDVIQTGVAPLAAVFGG
>Mature_496_residues
SIPYLTLITFLPAAGAILMALWPRLSGRAIKISSLLLTLVPLVLSLVVFAGFDRSSSMAGVIQFEENLPWISLLNANYHL
GVDGLSLPFLVLTTLLGVLAVLISWKVDLRIKEFFVWLLILQTSITGVFVSLDLLLFFIFWELELIPMYFLISIWGAGRK
EYSALKYVLYTLFGGAFILAGILILFFATGSLDIASLASTDLNNFLRPAMMVLTFFMFFIGFAIKLPAFPFHTWLPDAHT
DAPTAASVILAGTLLKMGGYAMLRLNVAMFPDVCRDWAPLILTIAVINVIYGAAITLKQTDIKRLIAYSSVSHMGFVLLG
IFTLGEISMNGAVLQMFSHGIITGLLFAITGVVMHNTHERDINKLGGLAKQMPRTAIIFILAGLGAMAVPATSGFIAEVS
VFLGSFQSSVVPGGQVFTMLCLLGLVLAAAYILWTVQRVFLGPGLEKFQMVKDADKTEIVFSLVFLVVMFGVGLYPQIIV
DVIQTGVAPLAAVFGG

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=374, Percent_Identity=32.620320855615, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI251831117, Length=318, Percent_Identity=28.3018867924528, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788613, Length=519, Percent_Identity=37.7649325626204, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1788827, Length=292, Percent_Identity=29.1095890410959, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788831, Length=288, Percent_Identity=31.9444444444444, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788614, Length=383, Percent_Identity=27.4151436031332, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788829, Length=306, Percent_Identity=25.8169934640523, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI145693160, Length=329, Percent_Identity=25.531914893617, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI2367154, Length=347, Percent_Identity=23.6311239193084, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.99.5 [C]

Molecular weight: Translated: 54031; Mature: 53900

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPYLTLITFLPAAGAILMALWPRLSGRAIKISSLLLTLVPLVLSLVVFAGFDRSSSMA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
GVIQFEENLPWISLLNANYHLGVDGLSLPFLVLTTLLGVLAVLISWKVDLRIKEFFVWLL
EEEEECCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILQTSITGVFVSLDLLLFFIFWELELIPMYFLISIWGAGRKEYSALKYVLYTLFGGAFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGILILFFATGSLDIASLASTDLNNFLRPAMMVLTFFMFFIGFAIKLPAFPFHTWLPDAH
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC
TDAPTAASVILAGTLLKMGGYAMLRLNVAMFPDVCRDWAPLILTIAVINVIYGAAITLKQ
CCCCHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEH
TDIKRLIAYSSVSHMGFVLLGIFTLGEISMNGAVLQMFSHGIITGLLFAITGVVMHNTHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
RDINKLGGLAKQMPRTAIIFILAGLGAMAVPATSGFIAEVSVFLGSFQSSVVPGGQVFTM
HHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
LCLLGLVLAAAYILWTVQRVFLGPGLEKFQMVKDADKTEIVFSLVFLVVMFGVGLYPQII
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHH
VDVIQTGVAPLAAVFGG
HHHHHHCHHHHHHHHCC
>Mature Secondary Structure 
SIPYLTLITFLPAAGAILMALWPRLSGRAIKISSLLLTLVPLVLSLVVFAGFDRSSSMA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
GVIQFEENLPWISLLNANYHLGVDGLSLPFLVLTTLLGVLAVLISWKVDLRIKEFFVWLL
EEEEECCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILQTSITGVFVSLDLLLFFIFWELELIPMYFLISIWGAGRKEYSALKYVLYTLFGGAFIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGILILFFATGSLDIASLASTDLNNFLRPAMMVLTFFMFFIGFAIKLPAFPFHTWLPDAH
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC
TDAPTAASVILAGTLLKMGGYAMLRLNVAMFPDVCRDWAPLILTIAVINVIYGAAITLKQ
CCCCHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEH
TDIKRLIAYSSVSHMGFVLLGIFTLGEISMNGAVLQMFSHGIITGLLFAITGVVMHNTHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
RDINKLGGLAKQMPRTAIIFILAGLGAMAVPATSGFIAEVSVFLGSFQSSVVPGGQVFTM
HHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
LCLLGLVLAAAYILWTVQRVFLGPGLEKFQMVKDADKTEIVFSLVFLVVMFGVGLYPQII
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHH
VDVIQTGVAPLAAVFGG
HHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Iron [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; ubiquinone [C]

Specific reaction: NADH + ubiquinone = NAD+ + ubiquinol [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA