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The map label for this gene is obgE

Identifier: 57233686

GI number: 57233686

Start: 1924

End: 3198

Strand: Direct

Name: obgE

Synonym: DET0002

Alternate gene names: 57233686

Gene position: 1924-3198 (Clockwise)

Preceding gene: 57233687

Following gene: 57233677

Centisome position: 0.13

GC content: 53.02

Gene sequence:

>1275_bases
ATGTTTGACAGAGTGGAAATACGGATTAAGTCCGGAGACGGCGGCAGCGGCAAGGTTAGTTTCCGCCGCGAAAAATTTGT
GCCTTACGGCGGGCCGGACGGGGGTGACGGCGGGGACGGGGGCAATGTATATCTGGAAGCTGATTCCGGGCTTTACAGCC
TTTTAAATTTTAAACATAAACGGGTGCATAAGGCGGCCAACGGCGAGAACGGTATGGGCAGCCGCTGTACCGGCCACAAC
GGGGCTGACCTGGTGATAAAAGTGCCGGTGGGTACGGTTGCTACTATTGTGGAAGAAAACGGCCAGAAACGGGTTCTGGC
TGATTTGGCCGCTGACGGAGACCGTACCCTGGTAGCCCGCGGCGGGCAGGGCGGACTGGGCAATACCCACTTTGTTTCGT
CCACCAACCAGGCCCCCATGCTGGCTCAGAAAGGCCAGCCGGGCGGCGAATATGAGCTGATACTGGAACTGAAACTGATT
GCCGATGTGGCTATTATCGGCTATCCGAATGTGGGCAAATCTTCGCTGCTTTCACTGCTTACCGCGGCCAAACCCAGGGT
GGCTAATTACCCGTTTACTACTCTTTCGCCGGTAATGGGGGTGGTGGAAAGGACAGAGGGTACATTTGTTATGGCGGAAG
TACCCGGTCTTATTGAAGACGCCCATCTGGGCAGGGGGCTGGGGCATGACTTTTTACGCCATATTTCCCGTACCCGTATG
GTTATCCATTTGCTGGACGGGACTTCGGATAACCCCATAGATGATATGATAAAGGTCAACAGCGAGCTGTACCTTTATGA
CGCCTCTTTGTCGGAACGCCCCCAGGTGGTGGCGGTAAACAAAATAGATGACGAACTGGTGCAGCTTAGACGTGAAGAGC
TGACCGAGACTTTTAAAGAAGCCGGGCTGGAGGTATTTTTTATTTCAGCTCTGACGGGCGAAGGGGTGGAGGTGCTTTTG
GATAAAGTAGCTGAAAAGCTGGCTATTCTTAAAGCGGCAGATGCACCTGAAACAGAAACTGACCAGGAAATCAAGGTATT
CCGGCCTGCCCCCAAGGGCAAAATGGGTTTCCATATAACCCGCCTGGAAGACGGCTGGCAGGTGGAAGCACCTGAAATTG
AGCGGATTATTGAGCACTCTGATATTGAAGATTTGGAGGTCAGGCGGCAGATAATGGTGCTTCTTAAACACCGGAATGTC
CAGCAGGCGTTGATAAAGGCCGGGGCAGTTATCGGCCAGAAGATTATAACCGGCAGGCTGGAATGGTATCTTTAA

Upstream 100 bases:

>100_bases
ATTATTAGTATTTCTGATATACTTAAAAATAAACCAGTTAAAGTTAATGGGATTTCGACAACTTAAGAATTAGATAACTT
TTTAGATAAGGTGTTTTTAT

Downstream 100 bases:

>100_bases
AAACAGGCATACTGGGGGGGACTTTTGACCCTATTCATACCGGCCACCTGATACTGGCAGAAGAGGTAAAAAAGAGGCTG
GGGCTGGATGAGATTATTTT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MFDRVEIRIKSGDGGSGKVSFRREKFVPYGGPDGGDGGDGGNVYLEADSGLYSLLNFKHKRVHKAANGENGMGSRCTGHN
GADLVIKVPVGTVATIVEENGQKRVLADLAADGDRTLVARGGQGGLGNTHFVSSTNQAPMLAQKGQPGGEYELILELKLI
ADVAIIGYPNVGKSSLLSLLTAAKPRVANYPFTTLSPVMGVVERTEGTFVMAEVPGLIEDAHLGRGLGHDFLRHISRTRM
VIHLLDGTSDNPIDDMIKVNSELYLYDASLSERPQVVAVNKIDDELVQLRREELTETFKEAGLEVFFISALTGEGVEVLL
DKVAEKLAILKAADAPETETDQEIKVFRPAPKGKMGFHITRLEDGWQVEAPEIERIIEHSDIEDLEVRRQIMVLLKHRNV
QQALIKAGAVIGQKIITGRLEWYL

Sequences:

>Translated_424_residues
MFDRVEIRIKSGDGGSGKVSFRREKFVPYGGPDGGDGGDGGNVYLEADSGLYSLLNFKHKRVHKAANGENGMGSRCTGHN
GADLVIKVPVGTVATIVEENGQKRVLADLAADGDRTLVARGGQGGLGNTHFVSSTNQAPMLAQKGQPGGEYELILELKLI
ADVAIIGYPNVGKSSLLSLLTAAKPRVANYPFTTLSPVMGVVERTEGTFVMAEVPGLIEDAHLGRGLGHDFLRHISRTRM
VIHLLDGTSDNPIDDMIKVNSELYLYDASLSERPQVVAVNKIDDELVQLRREELTETFKEAGLEVFFISALTGEGVEVLL
DKVAEKLAILKAADAPETETDQEIKVFRPAPKGKMGFHITRLEDGWQVEAPEIERIIEHSDIEDLEVRRQIMVLLKHRNV
QQALIKAGAVIGQKIITGRLEWYL
>Mature_424_residues
MFDRVEIRIKSGDGGSGKVSFRREKFVPYGGPDGGDGGDGGNVYLEADSGLYSLLNFKHKRVHKAANGENGMGSRCTGHN
GADLVIKVPVGTVATIVEENGQKRVLADLAADGDRTLVARGGQGGLGNTHFVSSTNQAPMLAQKGQPGGEYELILELKLI
ADVAIIGYPNVGKSSLLSLLTAAKPRVANYPFTTLSPVMGVVERTEGTFVMAEVPGLIEDAHLGRGLGHDFLRHISRTRM
VIHLLDGTSDNPIDDMIKVNSELYLYDASLSERPQVVAVNKIDDELVQLRREELTETFKEAGLEVFFISALTGEGVEVLL
DKVAEKLAILKAADAPETETDQEIKVFRPAPKGKMGFHITRLEDGWQVEAPEIERIIEHSDIEDLEVRRQIMVLLKHRNV
QQALIKAGAVIGQKIITGRLEWYL

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=320, Percent_Identity=42.5, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI111955139, Length=291, Percent_Identity=36.0824742268041, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI111955063, Length=188, Percent_Identity=35.1063829787234, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4557537, Length=88, Percent_Identity=39.7727272727273, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789574, Length=327, Percent_Identity=46.4831804281346, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=34.0579710144928, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508313, Length=329, Percent_Identity=37.0820668693009, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=304, Percent_Identity=29.2763157894737, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71981008, Length=92, Percent_Identity=36.9565217391304, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=132, Percent_Identity=40.9090909090909, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321612, Length=88, Percent_Identity=39.7727272727273, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129375, Length=323, Percent_Identity=39.6284829721362, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24585318, Length=276, Percent_Identity=39.1304347826087, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21356473, Length=91, Percent_Identity=40.6593406593407, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_DEHE1 (Q3ZAJ2)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_180757.1
- HSSP:   Q5SJ29
- ProteinModelPortal:   Q3ZAJ2
- SMR:   Q3ZAJ2
- STRING:   Q3ZAJ2
- GeneID:   3229149
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0002
- NMPDR:   fig|243164.3.peg.14
- TIGR:   DET0002
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   RNRTGAK
- ProtClustDB:   PRK12297
- BioCyc:   DETH243164:DET_0002-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 46209; Mature: 46209

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRVEIRIKSGDGGSGKVSFRREKFVPYGGPDGGDGGDGGNVYLEADSGLYSLLNFKHK
CCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHH
RVHKAANGENGMGSRCTGHNGADLVIKVPVGTVATIVEENGQKRVLADLAADGDRTLVAR
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHHCCCCEEEEHHHHCCCCEEEEEE
GGQGGLGNTHFVSSTNQAPMLAQKGQPGGEYELILELKLIADVAIIGYPNVGKSSLLSLL
CCCCCCCCCEEECCCCCCCCHHCCCCCCCCEEEEEEEEEEHEEEEEECCCCCHHHHHHHH
TAAKPRVANYPFTTLSPVMGVVERTEGTFVMAEVPGLIEDAHLGRGLGHDFLRHISRTRM
HHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHEE
VIHLLDGTSDNPIDDMIKVNSELYLYDASLSERPQVVAVNKIDDELVQLRREELTETFKE
EEEEECCCCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
AGLEVFFISALTGEGVEVLLDKVAEKLAILKAADAPETETDQEIKVFRPAPKGKMGFHIT
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEE
RLEDGWQVEAPEIERIIEHSDIEDLEVRRQIMVLLKHRNVQQALIKAGAVIGQKIITGRL
EECCCCEECCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCEE
EWYL
EECC
>Mature Secondary Structure
MFDRVEIRIKSGDGGSGKVSFRREKFVPYGGPDGGDGGDGGNVYLEADSGLYSLLNFKHK
CCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHH
RVHKAANGENGMGSRCTGHNGADLVIKVPVGTVATIVEENGQKRVLADLAADGDRTLVAR
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHHCCCCEEEEHHHHCCCCEEEEEE
GGQGGLGNTHFVSSTNQAPMLAQKGQPGGEYELILELKLIADVAIIGYPNVGKSSLLSLL
CCCCCCCCCEEECCCCCCCCHHCCCCCCCCEEEEEEEEEEHEEEEEECCCCCHHHHHHHH
TAAKPRVANYPFTTLSPVMGVVERTEGTFVMAEVPGLIEDAHLGRGLGHDFLRHISRTRM
HHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHEE
VIHLLDGTSDNPIDDMIKVNSELYLYDASLSERPQVVAVNKIDDELVQLRREELTETFKE
EEEEECCCCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
AGLEVFFISALTGEGVEVLLDKVAEKLAILKAADAPETETDQEIKVFRPAPKGKMGFHIT
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEE
RLEDGWQVEAPEIERIIEHSDIEDLEVRRQIMVLLKHRNVQQALIKAGAVIGQKIITGRL
EECCCCEECCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCEE
EWYL
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA