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The map label for this gene is dnaA [H]

Identifier: 57233687

GI number: 57233687

Start: 261

End: 1598

Strand: Direct

Name: dnaA [H]

Synonym: DET0001

Alternate gene names: 57233687

Gene position: 261-1598 (Clockwise)

Preceding gene: NA

Following gene: 57233686

Centisome position: 0.02

GC content: 53.14

Gene sequence:

>1338_bases
TTGTCTGTTCGGCCTGCACAAGAACTTTGGGAAACAGCCCTGGGGGAGATTGAACTTCAGGTAAACAAGCCCAATTTCCG
CACCTGGTTTGCCAAAACTGTCGGACTTAAGTACGACGGCAGTGAGTTTATTATAGGTGTTCCCAATACTTTCGTAGCCG
AATATCTGGAGGTCAATCAGCGTTCGCTGATTGAAAAAACCCTGATAAATATTACCCACAGCCCGGTTGAGCTGGGTTTC
CAGCTTGTCCAGTCCGCTCAGGTACAGGCTGCCGCTCCCCAAACAGCCAGAGAAAAAACCGTTTCACCCTTTAACCCCCG
TTACACCTTTGAATCCTTTATAGTGGGTTCCTGCAACCGCCTGGCTCATGCCGCTTCGCTGGCCGCCACCCAGAATCCCG
GCAAGAGCTACAACCCGCTTTATATCTATGCGGCAGCCGGTTTAGGCAAGACCCATCTTTTACAGGCTATCGGCCATCTA
GCAAACTTAAACCGCCGCAAGGCCCTGTATGTCAGCGGGGAACAGTTTACCACTGACTTTATATCATCTATCCGGAACGG
CCAAACCGAAGAGTTCCGTGCCCGTTACCGGGATGTAGATTTATTGCTGCTGGATGATGTCCAGTTTATCGGCGGCAAGG
AGCAGACCGAAGAATGCCTGTTCCATACCTTTAATGACCTGCATAACTCCAACCGCCAGATAGTCATTTCAGCAGATTCA
CCCCCCAAGTCACTGCCCCAGCTGGCCGAAAGACTGCGTTCCCGTTTTGAGTGGGGGCTGACGATTGAGATTGAACCGCC
GGATGAAAAAACCCGCTTGGAGCTTTTGCAGCTTAAAGCTGAGCAGTCCGGCACCGAACTTAATATGGACACCCTGGAGT
ACCTGGCTCAGGAAGTAAAGCATAATATCCGCGAACTGGAAGGCAGCCTTAACCGGGTGCTGGCCTATGCCCGCCTGCTA
AGGGCTACCATTACCCCGGACCTGGCCGCCAGAGCCCTGTCGGATATCGGCTCACGCCCGGTCAGGGAAAACAGCCCTCT
CCGCCCCGGTAATATAATTTCAGCGGTATCCCAGGTATTTCAAATACCCGCAACCGAACTTTTGGGTGCCGCCCGTGACA
AAGATACCGCTCTGGCCCGTCAGTTTGCCATGTTTATGCTAAAGCAGCAAAACTCCGCCTCACTGGTAGAAATAGGCCAG
TCCCTGGGGGGCAGAAGCGCTTCCACCGTCAGCCACGCCTGCGATAAAATCCAGCTGGAGTTGGAAAACAGCGCCTTTCT
GCGCCTGAAAATGTCCGAGGTTCAAAACCAGCTTTCCCAGCAGCGCCTTTCCCGCTGA

Upstream 100 bases:

>100_bases
TAACAGATTGGTACTTATTCTTTAAGGGGTGGATCATTTTCATGGCAGAGTGCTTGCCCCCTTGATTTCAGATACGGTTT
AATTACTGGGAGGGATATTT

Downstream 100 bases:

>100_bases
TATTAGCCCTTTTCGCCGCACCGCTTTTCCTTATCCTTATATTTTTCTTTATTTTCATTCTGCCAGCAGGGTGCTTTTGC
CGGTTTTTCTATTCTTTTTA

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSVRPAQELWETALGEIELQVNKPNFRTWFAKTVGLKYDGSEFIIGVPNTFVAEYLEVNQRSLIEKTLINITHSPVELGF
QLVQSAQVQAAAPQTAREKTVSPFNPRYTFESFIVGSCNRLAHAASLAATQNPGKSYNPLYIYAAAGLGKTHLLQAIGHL
ANLNRRKALYVSGEQFTTDFISSIRNGQTEEFRARYRDVDLLLLDDVQFIGGKEQTEECLFHTFNDLHNSNRQIVISADS
PPKSLPQLAERLRSRFEWGLTIEIEPPDEKTRLELLQLKAEQSGTELNMDTLEYLAQEVKHNIRELEGSLNRVLAYARLL
RATITPDLAARALSDIGSRPVRENSPLRPGNIISAVSQVFQIPATELLGAARDKDTALARQFAMFMLKQQNSASLVEIGQ
SLGGRSASTVSHACDKIQLELENSAFLRLKMSEVQNQLSQQRLSR

Sequences:

>Translated_445_residues
MSVRPAQELWETALGEIELQVNKPNFRTWFAKTVGLKYDGSEFIIGVPNTFVAEYLEVNQRSLIEKTLINITHSPVELGF
QLVQSAQVQAAAPQTAREKTVSPFNPRYTFESFIVGSCNRLAHAASLAATQNPGKSYNPLYIYAAAGLGKTHLLQAIGHL
ANLNRRKALYVSGEQFTTDFISSIRNGQTEEFRARYRDVDLLLLDDVQFIGGKEQTEECLFHTFNDLHNSNRQIVISADS
PPKSLPQLAERLRSRFEWGLTIEIEPPDEKTRLELLQLKAEQSGTELNMDTLEYLAQEVKHNIRELEGSLNRVLAYARLL
RATITPDLAARALSDIGSRPVRENSPLRPGNIISAVSQVFQIPATELLGAARDKDTALARQFAMFMLKQQNSASLVEIGQ
SLGGRSASTVSHACDKIQLELENSAFLRLKMSEVQNQLSQQRLSR
>Mature_444_residues
SVRPAQELWETALGEIELQVNKPNFRTWFAKTVGLKYDGSEFIIGVPNTFVAEYLEVNQRSLIEKTLINITHSPVELGFQ
LVQSAQVQAAAPQTAREKTVSPFNPRYTFESFIVGSCNRLAHAASLAATQNPGKSYNPLYIYAAAGLGKTHLLQAIGHLA
NLNRRKALYVSGEQFTTDFISSIRNGQTEEFRARYRDVDLLLLDDVQFIGGKEQTEECLFHTFNDLHNSNRQIVISADSP
PKSLPQLAERLRSRFEWGLTIEIEPPDEKTRLELLQLKAEQSGTELNMDTLEYLAQEVKHNIRELEGSLNRVLAYARLLR
ATITPDLAARALSDIGSRPVRENSPLRPGNIISAVSQVFQIPATELLGAARDKDTALARQFAMFMLKQQNSASLVEIGQS
LGGRSASTVSHACDKIQLELENSAFLRLKMSEVQNQLSQQRLSR

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=466, Percent_Identity=33.2618025751073, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI226510964, Length=222, Percent_Identity=29.7297297297297, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 49740; Mature: 49609

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRPAQELWETALGEIELQVNKPNFRTWFAKTVGLKYDGSEFIIGVPNTFVAEYLEVNQ
CCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHCCEECCCEEEEECCHHHHHHHHHHHH
RSLIEKTLINITHSPVELGFQLVQSAQVQAAAPQTAREKTVSPFNPRYTFESFIVGSCNR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
LAHAASLAATQNPGKSYNPLYIYAAAGLGKTHLLQAIGHLANLNRRKALYVSGEQFTTDF
HHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
ISSIRNGQTEEFRARYRDVDLLLLDDVQFIGGKEQTEECLFHTFNDLHNSNRQIVISADS
HHHHHCCCCHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
PPKSLPQLAERLRSRFEWGLTIEIEPPDEKTRLELLQLKAEQSGTELNMDTLEYLAQEVK
CCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
HNIRELEGSLNRVLAYARLLRATITPDLAARALSDIGSRPVRENSPLRPGNIISAVSQVF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
QIPATELLGAARDKDTALARQFAMFMLKQQNSASLVEIGQSLGGRSASTVSHACDKIQLE
HCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEEE
LENSAFLRLKMSEVQNQLSQQRLSR
ECCCEEEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVRPAQELWETALGEIELQVNKPNFRTWFAKTVGLKYDGSEFIIGVPNTFVAEYLEVNQ
CCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHCCEECCCEEEEECCHHHHHHHHHHHH
RSLIEKTLINITHSPVELGFQLVQSAQVQAAAPQTAREKTVSPFNPRYTFESFIVGSCNR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
LAHAASLAATQNPGKSYNPLYIYAAAGLGKTHLLQAIGHLANLNRRKALYVSGEQFTTDF
HHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
ISSIRNGQTEEFRARYRDVDLLLLDDVQFIGGKEQTEECLFHTFNDLHNSNRQIVISADS
HHHHHCCCCHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
PPKSLPQLAERLRSRFEWGLTIEIEPPDEKTRLELLQLKAEQSGTELNMDTLEYLAQEVK
CCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
HNIRELEGSLNRVLAYARLLRATITPDLAARALSDIGSRPVRENSPLRPGNIISAVSQVF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
QIPATELLGAARDKDTALARQFAMFMLKQQNSASLVEIGQSLGGRSASTVSHACDKIQLE
HCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEEE
LENSAFLRLKMSEVQNQLSQQRLSR
ECCCEEEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA