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The map label for this gene is moeB [H]

Identifier: 56963489

GI number: 56963489

Start: 1851047

End: 1852060

Strand: Direct

Name: moeB [H]

Synonym: ABC1724

Alternate gene names: 56963489

Gene position: 1851047-1852060 (Clockwise)

Preceding gene: 56963488

Following gene: 56963490

Centisome position: 43.01

GC content: 46.06

Gene sequence:

>1014_bases
ATGGCTCATTTAGAACGTTATTCAAGACAGCTATTGTTTTCTGGAATTGGTGAGGAAGGGCAACAACGGCTATTAAACAG
CCGTGTGCTAATTGTTGGCGTTGGCGCCTTAGGAACGGTCCTTGCTAACCACATGGTCCGTTCTGGCATTGGCCATATCC
GCATTGTCGATCGTGACTACGTGGAAATGAGCAATTTGCAAAGGCAAATGCTGTTTACTGAAAGCGATGTAGAACAAGCA
TTGCCAAAGGCGGTCGCTGCAAAACAAATGTTAGAAAAAGTGAACGGATCGGTACATATTGAAGCATTTGTAGAAGATGT
AACGATACAAAATGTGGACAGGCTAATGGAAGGTATGGATCTCGTCTTAGATGGGACGGATAATTTTAAAACGCGTTTTT
TGCTTAATGATGCCTGTTTTAAGAAAGGCATTCCTTTTGGGTATGGTGGAGCTGTAAGCGCCAGGGGCATGAGTGCTTTC
CTAGTTCCTGAAAAAACGCCATGCTTGCGCTGTTTTATCACAAGCGGTGCCTCTCCAGGGGAGACGTGTGACACAGTCGG
CGTCATTGCTCCTGTTGTTGATATTGTGGCCTCTTACCAGGTGGTCGAGGCAATGAAATACTTAGTCGGAGCAACAGATC
AATTACGGCGTTCTGTACAGACATTTGATTTGTGGGGCAATTATGACCATAAGCTCAAGTTTCAGGCTCCGAAATCAAAC
TGCCCGACTTGCCAATTGCATGAGTATCCGGCATTACAAGTCGAGCAAGAAGCAGAGACAACATTATGTGGTAGAGACAC
TGTACAAATTGCGACTGGCTCGCGGTTTCAGTTAAAAGAGTGGGCAGCGAAGCTTCAACCAATCGCCACTGTGAAAGAAA
CGCCCTTTCTTCTCCGTGTCTCTCTCCCAGAGGGTGAACAATTGGTCCTATTTCCTGATGGGCGAGTGCTTGTACAAGGA
ACGGAAGATATTAGCCGCGCCAGAACGCTTTTCAGCAAATATATTGGCGACTAA

Upstream 100 bases:

>100_bases
AGGAGCGGCGCTTGGCGTTTTAGCAGTCGCATTGATTGGGCGATAACGGGGCGGTTGCGATGGCTGTTAACATAATTGGT
GGAACAAGGAGGAAACGCGC

Downstream 100 bases:

>100_bases
AAAAGTCGGCTGGATAAAAAACATACAGCTAGTACCGGAGCGCCCATGTCGTTCTTTCTCGTTTCGTGCCATTCAAATTC
AACACCTTAGGCTACCTGTT

Product: thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAHLERYSRQLLFSGIGEEGQQRLLNSRVLIVGVGALGTVLANHMVRSGIGHIRIVDRDYVEMSNLQRQMLFTESDVEQA
LPKAVAAKQMLEKVNGSVHIEAFVEDVTIQNVDRLMEGMDLVLDGTDNFKTRFLLNDACFKKGIPFGYGGAVSARGMSAF
LVPEKTPCLRCFITSGASPGETCDTVGVIAPVVDIVASYQVVEAMKYLVGATDQLRRSVQTFDLWGNYDHKLKFQAPKSN
CPTCQLHEYPALQVEQEAETTLCGRDTVQIATGSRFQLKEWAAKLQPIATVKETPFLLRVSLPEGEQLVLFPDGRVLVQG
TEDISRARTLFSKYIGD

Sequences:

>Translated_337_residues
MAHLERYSRQLLFSGIGEEGQQRLLNSRVLIVGVGALGTVLANHMVRSGIGHIRIVDRDYVEMSNLQRQMLFTESDVEQA
LPKAVAAKQMLEKVNGSVHIEAFVEDVTIQNVDRLMEGMDLVLDGTDNFKTRFLLNDACFKKGIPFGYGGAVSARGMSAF
LVPEKTPCLRCFITSGASPGETCDTVGVIAPVVDIVASYQVVEAMKYLVGATDQLRRSVQTFDLWGNYDHKLKFQAPKSN
CPTCQLHEYPALQVEQEAETTLCGRDTVQIATGSRFQLKEWAAKLQPIATVKETPFLLRVSLPEGEQLVLFPDGRVLVQG
TEDISRARTLFSKYIGD
>Mature_336_residues
AHLERYSRQLLFSGIGEEGQQRLLNSRVLIVGVGALGTVLANHMVRSGIGHIRIVDRDYVEMSNLQRQMLFTESDVEQAL
PKAVAAKQMLEKVNGSVHIEAFVEDVTIQNVDRLMEGMDLVLDGTDNFKTRFLLNDACFKKGIPFGYGGAVSARGMSAFL
VPEKTPCLRCFITSGASPGETCDTVGVIAPVVDIVASYQVVEAMKYLVGATDQLRRSVQTFDLWGNYDHKLKFQAPKSNC
PTCQLHEYPALQVEQEAETTLCGRDTVQIATGSRFQLKEWAAKLQPIATVKETPFLLRVSLPEGEQLVLFPDGRVLVQGT
EDISRARTLFSKYIGD

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=242, Percent_Identity=34.297520661157, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI150417996, Length=173, Percent_Identity=28.3236994219653, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4885649, Length=163, Percent_Identity=29.4478527607362, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787048, Length=209, Percent_Identity=36.3636363636364, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082356, Length=240, Percent_Identity=35.8333333333333, Blast_Score=130, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17540406, Length=242, Percent_Identity=32.6446280991736, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193203301, Length=155, Percent_Identity=25.1612903225806, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=214, Percent_Identity=31.7757009345794, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320598, Length=162, Percent_Identity=30.8641975308642, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325323, Length=167, Percent_Identity=27.5449101796407, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322639, Length=172, Percent_Identity=28.4883720930233, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24582879, Length=289, Percent_Identity=30.7958477508651, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28573937, Length=166, Percent_Identity=29.5180722891566, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24660640, Length=152, Percent_Identity=30.2631578947368, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24641311, Length=211, Percent_Identity=31.2796208530806, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 37276; Mature: 37145

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHLERYSRQLLFSGIGEEGQQRLLNSRVLIVGVGALGTVLANHMVRSGIGHIRIVDRDY
CCHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCEEEEECHHH
VEMSNLQRQMLFTESDVEQALPKAVAAKQMLEKVNGSVHIEAFVEDVTIQNVDRLMEGMD
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCE
LVLDGTDNFKTRFLLNDACFKKGIPFGYGGAVSARGMSAFLVPEKTPCLRCFITSGASPG
EEEECCCCCEEEEEECHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCC
ETCDTVGVIAPVVDIVASYQVVEAMKYLVGATDQLRRSVQTFDLWGNYDHKLKFQAPKSN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCEEEEECCCCC
CPTCQLHEYPALQVEQEAETTLCGRDTVQIATGSRFQLKEWAAKLQPIATVKETPFLLRV
CCEEEECCCCCCEECCCHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHCCCCCEEEEE
SLPEGEQLVLFPDGRVLVQGTEDISRARTLFSKYIGD
ECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AHLERYSRQLLFSGIGEEGQQRLLNSRVLIVGVGALGTVLANHMVRSGIGHIRIVDRDY
CHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCEEEEECHHH
VEMSNLQRQMLFTESDVEQALPKAVAAKQMLEKVNGSVHIEAFVEDVTIQNVDRLMEGMD
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCE
LVLDGTDNFKTRFLLNDACFKKGIPFGYGGAVSARGMSAFLVPEKTPCLRCFITSGASPG
EEEECCCCCEEEEEECHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCC
ETCDTVGVIAPVVDIVASYQVVEAMKYLVGATDQLRRSVQTFDLWGNYDHKLKFQAPKSN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCEEEEECCCCC
CPTCQLHEYPALQVEQEAETTLCGRDTVQIATGSRFQLKEWAAKLQPIATVKETPFLLRV
CCEEEECCCCCCEECCCHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHCCCCCEEEEE
SLPEGEQLVLFPDGRVLVQGTEDISRARTLFSKYIGD
ECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]