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The map label for this gene is nhaC [H]

Identifier: 56963490

GI number: 56963490

Start: 1852328

End: 1853713

Strand: Direct

Name: nhaC [H]

Synonym: ABC1725

Alternate gene names: 56963490

Gene position: 1852328-1853713 (Clockwise)

Preceding gene: 56963489

Following gene: 56963491

Centisome position: 43.04

GC content: 45.89

Gene sequence:

>1386_bases
ATGGGAAAGAAACCTAGCTTATTAATGGTTATAGTCTTTTTGCTATTTTTTATCGCTATATTAGGCGGTTGCATGTTCTT
CCTTAAAATTGATCCCCATCTTCCAATTTTGTTGGCGCTTATTGTGACAATTATTTGGGGTCGGTTATTGGGCTTCTCTT
ATAAATCATTAGAAGGGGCGCTCATCAAAGGCATACAAGGGGGCGTTGCCCCATTATTGATCTTAATGCTTGTTGGGGCA
GTCATCGCCGTGTGGATGATGAGCGGCACAGTACCAACGCTATTGTATTTTGGAGTACAGTTGTTGACGCCTGAATGGTT
TGCCATTAGCGCTTTAACCGTCTGCATTCTCGTTTCCACTTTTACAGGAAGCGCGTTTACGACTGTTGGCTCAGTTGGCG
TGGCGATTATGGGCGTCGGCATTGCCTTGGGCGTGCCAGCCCCACTCGCTGCTGGAGCAGTTGTTTGTGGCGCTTGTTTC
GGCGATAAAATGTCGCCTTTATCCGATACAACCAACTTTGCACCTGCAGTGGCCGGTGAACAGCTTTTTGCCCATATTAA
GCATTTAATGTGGACGACCGTACCAGCGCTTTTCATCACTTATTTGTTGTTTTTTATAATCGGTGGGCAACAAAGCGGAC
AGCCGTCTGATCTTGCCGGGCTCTTGGAAGCATTAAAGGCATCGTTTACGATTAGCTGGCTCACGTTGCTATCGCCTTTG
CTCGTTGTTCTGTTGGCGATGCTACGGTTGCCGGTGCTGCCTGTTTTAGTTGCCGGAATTGTTTCAGGCTTGTTGTTGAC
TGTCGTGGTTCAGCAAGAGTCGTCACTGGCTTATATGTTAACTGTATTGCAGTCGGGCTTTGAGGGAACGACTGGCAATG
AACTATTGGACGGCATTCTCAATGCTGGCGGAATTCAATCGATGATGTGGTCCGTCTCATTAGTGTTGCTGGCGCTTGCT
TTAGGCGGCGTGATTCAACACATTGGTTTTATTGAAGCGTTGTTTGCAAACATGAAAAAGCTATTGGCAAAAAGGGGGCA
TTTAATTGCTTCAACAGCATTAGCCTCGATCGGCACTAATGCTGTAACGGGGGAACAATATTTATCGATCTTATTACCAG
GCAGTTTTTTCAAACGTTACTATGAACAGGCAGGGCTTGCCCCGAAAAATTTGTCGCGGACACTTGAAGATGCGGGTACA
CTTGTCAATCCCCTTATTCCATGGGGGGTGAGCGGCGCTTTTTTTGCACAAACACTTGGTGTATCTGTGCTTGAATACGC
TCCTTTTGCTTTTTTCCTTATTTTATCTCCACTGCTTACGGTTGCCTTTGGCTATTTAGGAATCGGCATAGCTCCTTTGG
ATAAAAACAAACAAAAGTCGGTATAG

Upstream 100 bases:

>100_bases
CGAAAAAAAGGAAGACATTTAAGCTAGCAGAAGTTGTTGCTAATTCGCACCGACGCGGTAAAGTGACATAGAATGAAGAA
AAGGACTTCGGTGTTTTATT

Downstream 100 bases:

>100_bases
TAAGAGTGGAGGTGACGTTATGCGTCAAGTGTTAGTCGCTGTCTCGACGTTTATTGCCATTCTTGCTATTTGTAAATACC
GATATCGGCTGTTAAATGCG

Product: Na+:H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MGKKPSLLMVIVFLLFFIAILGGCMFFLKIDPHLPILLALIVTIIWGRLLGFSYKSLEGALIKGIQGGVAPLLILMLVGA
VIAVWMMSGTVPTLLYFGVQLLTPEWFAISALTVCILVSTFTGSAFTTVGSVGVAIMGVGIALGVPAPLAAGAVVCGACF
GDKMSPLSDTTNFAPAVAGEQLFAHIKHLMWTTVPALFITYLLFFIIGGQQSGQPSDLAGLLEALKASFTISWLTLLSPL
LVVLLAMLRLPVLPVLVAGIVSGLLLTVVVQQESSLAYMLTVLQSGFEGTTGNELLDGILNAGGIQSMMWSVSLVLLALA
LGGVIQHIGFIEALFANMKKLLAKRGHLIASTALASIGTNAVTGEQYLSILLPGSFFKRYYEQAGLAPKNLSRTLEDAGT
LVNPLIPWGVSGAFFAQTLGVSVLEYAPFAFFLILSPLLTVAFGYLGIGIAPLDKNKQKSV

Sequences:

>Translated_461_residues
MGKKPSLLMVIVFLLFFIAILGGCMFFLKIDPHLPILLALIVTIIWGRLLGFSYKSLEGALIKGIQGGVAPLLILMLVGA
VIAVWMMSGTVPTLLYFGVQLLTPEWFAISALTVCILVSTFTGSAFTTVGSVGVAIMGVGIALGVPAPLAAGAVVCGACF
GDKMSPLSDTTNFAPAVAGEQLFAHIKHLMWTTVPALFITYLLFFIIGGQQSGQPSDLAGLLEALKASFTISWLTLLSPL
LVVLLAMLRLPVLPVLVAGIVSGLLLTVVVQQESSLAYMLTVLQSGFEGTTGNELLDGILNAGGIQSMMWSVSLVLLALA
LGGVIQHIGFIEALFANMKKLLAKRGHLIASTALASIGTNAVTGEQYLSILLPGSFFKRYYEQAGLAPKNLSRTLEDAGT
LVNPLIPWGVSGAFFAQTLGVSVLEYAPFAFFLILSPLLTVAFGYLGIGIAPLDKNKQKSV
>Mature_460_residues
GKKPSLLMVIVFLLFFIAILGGCMFFLKIDPHLPILLALIVTIIWGRLLGFSYKSLEGALIKGIQGGVAPLLILMLVGAV
IAVWMMSGTVPTLLYFGVQLLTPEWFAISALTVCILVSTFTGSAFTTVGSVGVAIMGVGIALGVPAPLAAGAVVCGACFG
DKMSPLSDTTNFAPAVAGEQLFAHIKHLMWTTVPALFITYLLFFIIGGQQSGQPSDLAGLLEALKASFTISWLTLLSPLL
VVLLAMLRLPVLPVLVAGIVSGLLLTVVVQQESSLAYMLTVLQSGFEGTTGNELLDGILNAGGIQSMMWSVSLVLLALAL
GGVIQHIGFIEALFANMKKLLAKRGHLIASTALASIGTNAVTGEQYLSILLPGSFFKRYYEQAGLAPKNLSRTLEDAGTL
VNPLIPWGVSGAFFAQTLGVSVLEYAPFAFFLILSPLLTVAFGYLGIGIAPLDKNKQKSV

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 48591; Mature: 48460

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKPSLLMVIVFLLFFIAILGGCMFFLKIDPHLPILLALIVTIIWGRLLGFSYKSLEGA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
LIKGIQGGVAPLLILMLVGAVIAVWMMSGTVPTLLYFGVQLLTPEWFAISALTVCILVST
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FTGSAFTTVGSVGVAIMGVGIALGVPAPLAAGAVVCGACFGDKMSPLSDTTNFAPAVAGE
HCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
QLFAHIKHLMWTTVPALFITYLLFFIIGGQQSGQPSDLAGLLEALKASFTISWLTLLSPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LVVLLAMLRLPVLPVLVAGIVSGLLLTVVVQQESSLAYMLTVLQSGFEGTTGNELLDGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
NAGGIQSMMWSVSLVLLALALGGVIQHIGFIEALFANMKKLLAKRGHLIASTALASIGTN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
AVTGEQYLSILLPGSFFKRYYEQAGLAPKNLSRTLEDAGTLVNPLIPWGVSGAFFAQTLG
CCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VSVLEYAPFAFFLILSPLLTVAFGYLGIGIAPLDKNKQKSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKKPSLLMVIVFLLFFIAILGGCMFFLKIDPHLPILLALIVTIIWGRLLGFSYKSLEGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]