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The map label for this gene is nagB

Identifier: 56963255

GI number: 56963255

Start: 1610791

End: 1611534

Strand: Direct

Name: nagB

Synonym: ABC1490

Alternate gene names: 56963255

Gene position: 1610791-1611534 (Clockwise)

Preceding gene: 56963254

Following gene: 56963256

Centisome position: 37.43

GC content: 43.55

Gene sequence:

>744_bases
ATGAATATTATTCACGTAAAAAATTATGAAGAAATGAGCCAAAAAGCAGCAGCACTCTTGTTTGAGCGAATTCAGCAGTC
TCCGAAAATAACGCTCGGACTTGCGACAGGGGGCACACCGGAAAATACGTATACCGCTTTGATTGCAAAAGCAAAGGAAA
ACGGCCAATCATTTTCACATGTGCAAACGTTCAATTTAGATGAATATGTCGGCTTGCCTGCTGAGGACAAAAATAGTTAC
CGCCACTATATGGAGCAACGGTTGTTTGATCATATCGATATTCCAAAAGAAAAAACGCATTTGCCAAATGGAATGGCTCC
GTCCCTCGAAGAAGAATGCCGTGCTTATGAAAACATGATTGCCGACGCGGGCGGAATTGACATTCAACTTCTCGGTATTG
GCAGCAATGGCCATATCGGTTTTAATGAGCCAGGGACGCCATTTTCGAGCAAAACCCATGTTGTCGAGCTGGCCGAAGAA
ACACGCAAAGCCAATGCTAGGTATTTCCCAACTTTAGAAGATGTGCCGAAACAAGCGATTACAATGGGGATTCAAACGAT
TATGGAAGCGAAAGAAATTTTGTTGCTTATTTCCGGGAAAGCAAAAGCAGAAGCGTTCGCCAAATTATGCTCAGATGAAG
TAACTGAGGCGTTCCCGGCTTCTATATTAAACAAGCATCCAAATGTCACAGTCATTGCCGACGAAGAAGCGGCAAGCGTT
TATACGCAAAAAGCACACTTGTAG

Upstream 100 bases:

>100_bases
TGCCTGGGAAAGATGGCGATTTTACTGTGCTCACGAAAGAGGGCGACGTGTTGTACACCTACTGTTTAGGGAAAAAAGCA
TATGGCAAGGAGGATGACGT

Downstream 100 bases:

>100_bases
AATAACTTTGGTTAAGAAAAGAGAGCCGGCGCAACATTGATACGGTTCTCTTTTTGTATGATTTAGTAAGAAAATCGGCT
GATCCTGCCGCTAATAGTTC

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MNIIHVKNYEEMSQKAAALLFERIQQSPKITLGLATGGTPENTYTALIAKAKENGQSFSHVQTFNLDEYVGLPAEDKNSY
RHYMEQRLFDHIDIPKEKTHLPNGMAPSLEEECRAYENMIADAGGIDIQLLGIGSNGHIGFNEPGTPFSSKTHVVELAEE
TRKANARYFPTLEDVPKQAITMGIQTIMEAKEILLLISGKAKAEAFAKLCSDEVTEAFPASILNKHPNVTVIADEEAASV
YTQKAHL

Sequences:

>Translated_247_residues
MNIIHVKNYEEMSQKAAALLFERIQQSPKITLGLATGGTPENTYTALIAKAKENGQSFSHVQTFNLDEYVGLPAEDKNSY
RHYMEQRLFDHIDIPKEKTHLPNGMAPSLEEECRAYENMIADAGGIDIQLLGIGSNGHIGFNEPGTPFSSKTHVVELAEE
TRKANARYFPTLEDVPKQAITMGIQTIMEAKEILLLISGKAKAEAFAKLCSDEVTEAFPASILNKHPNVTVIADEEAASV
YTQKAHL
>Mature_247_residues
MNIIHVKNYEEMSQKAAALLFERIQQSPKITLGLATGGTPENTYTALIAKAKENGQSFSHVQTFNLDEYVGLPAEDKNSY
RHYMEQRLFDHIDIPKEKTHLPNGMAPSLEEECRAYENMIADAGGIDIQLLGIGSNGHIGFNEPGTPFSSKTHVVELAEE
TRKANARYFPTLEDVPKQAITMGIQTIMEAKEILLLISGKAKAEAFAKLCSDEVTEAFPASILNKHPNVTVIADEEAASV
YTQKAHL

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI19923881, Length=243, Percent_Identity=42.3868312757202, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI13027378, Length=243, Percent_Identity=42.798353909465, Blast_Score=192, Evalue=2e-49,
Organism=Escherichia coli, GI1786893, Length=241, Percent_Identity=40.2489626556017, Blast_Score=190, Evalue=9e-50,
Organism=Escherichia coli, GI1789530, Length=231, Percent_Identity=30.7359307359307, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI48994958, Length=235, Percent_Identity=28.0851063829787, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17554876, Length=242, Percent_Identity=38.8429752066116, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24581960, Length=243, Percent_Identity=39.0946502057613, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI19920764, Length=243, Percent_Identity=39.0946502057613, Blast_Score=187, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_BACSK (Q5WHY0)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_174986.1
- HSSP:   O35000
- ProteinModelPortal:   Q5WHY0
- SMR:   Q5WHY0
- STRING:   Q5WHY0
- EnsemblBacteria:   EBBACT00000046601
- GeneID:   3204510
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1490
- NMPDR:   fig|66692.3.peg.1864
- eggNOG:   COG0363
- GeneTree:   EBGT00050000002591
- HOGENOM:   HBG725991
- OMA:   IIAEHPI
- BioCyc:   BCLA66692:ABC1490-MONOMER
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 27246; Mature: 27246

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 67-67 ACT_SITE 136-136 ACT_SITE 138-138 ACT_SITE 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIHVKNYEEMSQKAAALLFERIQQSPKITLGLATGGTPENTYTALIAKAKENGQSFSH
CCEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHH
VQTFNLDEYVGLPAEDKNSYRHYMEQRLFDHIDIPKEKTHLPNGMAPSLEEECRAYENMI
EEECCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
ADAGGIDIQLLGIGSNGHIGFNEPGTPFSSKTHVVELAEETRKANARYFPTLEDVPKQAI
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TMGIQTIMEAKEILLLISGKAKAEAFAKLCSDEVTEAFPASILNKHPNVTVIADEEAASV
HHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
YTQKAHL
HHHHCCC
>Mature Secondary Structure
MNIIHVKNYEEMSQKAAALLFERIQQSPKITLGLATGGTPENTYTALIAKAKENGQSFSH
CCEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHH
VQTFNLDEYVGLPAEDKNSYRHYMEQRLFDHIDIPKEKTHLPNGMAPSLEEECRAYENMI
EEECCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
ADAGGIDIQLLGIGSNGHIGFNEPGTPFSSKTHVVELAEETRKANARYFPTLEDVPKQAI
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TMGIQTIMEAKEILLLISGKAKAEAFAKLCSDEVTEAFPASILNKHPNVTVIADEEAASV
HHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
YTQKAHL
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA