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The map label for this gene is folK [H]

Identifier: 55981718

GI number: 55981718

Start: 1637693

End: 1638172

Strand: Reverse

Name: folK [H]

Synonym: TTHA1749

Alternate gene names: 55981718

Gene position: 1638172-1637693 (Counterclockwise)

Preceding gene: 55981719

Following gene: 55981717

Centisome position: 88.56

GC content: 70.0

Gene sequence:

>480_bases
ATGACGGCCTACGTGGCCTTGGGCTCCAACCTCGGGGACCGCGCGGCCTACCTCTTGGAGGGGCTTTCCCGGCTCTCCCG
CCTCCCCGAAACCCGCCTCCTCCGCCTCTCCTCCCTCTACGAGACCGAGCCTTTAGGCCCGCCCCAGCCCCTCTACCTGA
ACCTGGTGGCCGAGGTGGAGACGGCTCTTCCCCCCAGGGGCCTCCTCGAGGCCATGCTCGCCATAGAGCGGGCTTTGGGG
CGGGAGCGCAAGGAGCGCTACGGCCCCAGGACCCTGGACCTGGACCTCCTCCTTTACGGGGACCTCGTCCTGGAGGAGGA
GGACCTGGTGCTGCCCCACCCGAGGCTCCACGAGCGGGCCTTCGTCCTCGTGCCCCTTTGCGACCTCGTTCCCCAAGGGC
GGCACCCCCTCCTGGGCCGGACCTTCGCCGAGCTCCTCGCGGGGCTGGACCCTTCTGGGGTCCGGCCCTATGTGGTATAG

Upstream 100 bases:

>100_bases
CCGGGCTGGTGGTGGCCAAGGTGGGGGACGAGGTCCTGGTGGTGCCCAAGGACTGGGCCCGGGAGGTGCGGGAGGTGGTG
AAACGCCTCGAGGCCCAGGA

Downstream 100 bases:

>100_bases
TGGGGGCACCGCGGGTGGATTCCGCGCGAGGAGAAGGAACGTGGAACTAGAAGCAGGAACCGTTGTGGAAGGCCGCGTGG
TGCGGGTGGTGAGCTTTGGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTAYVALGSNLGDRAAYLLEGLSRLSRLPETRLLRLSSLYETEPLGPPQPLYLNLVAEVETALPPRGLLEAMLAIERALG
RERKERYGPRTLDLDLLLYGDLVLEEEDLVLPHPRLHERAFVLVPLCDLVPQGRHPLLGRTFAELLAGLDPSGVRPYVV

Sequences:

>Translated_159_residues
MTAYVALGSNLGDRAAYLLEGLSRLSRLPETRLLRLSSLYETEPLGPPQPLYLNLVAEVETALPPRGLLEAMLAIERALG
RERKERYGPRTLDLDLLLYGDLVLEEEDLVLPHPRLHERAFVLVPLCDLVPQGRHPLLGRTFAELLAGLDPSGVRPYVV
>Mature_158_residues
TAYVALGSNLGDRAAYLLEGLSRLSRLPETRLLRLSSLYETEPLGPPQPLYLNLVAEVETALPPRGLLEAMLAIERALGR
ERKERYGPRTLDLDLLLYGDLVLEEEDLVLPHPRLHERAFVLVPLCDLVPQGRHPLLGRTFAELLAGLDPSGVRPYVV

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=132, Percent_Identity=45.4545454545455, Blast_Score=108, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324073, Length=155, Percent_Identity=39.3548387096774, Blast_Score=104, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17713; Mature: 17582

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYVALGSNLGDRAAYLLEGLSRLSRLPETRLLRLSSLYETEPLGPPQPLYLNLVAEVE
CEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
TALPPRGLLEAMLAIERALGRERKERYGPRTLDLDLLLYGDLVLEEEDLVLPHPRLHERA
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCEEECCCCCCCCCCCCCCCC
FVLVPLCDLVPQGRHPLLGRTFAELLAGLDPSGVRPYVV
EEEEEHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TAYVALGSNLGDRAAYLLEGLSRLSRLPETRLLRLSSLYETEPLGPPQPLYLNLVAEVE
EEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
TALPPRGLLEAMLAIERALGRERKERYGPRTLDLDLLLYGDLVLEEEDLVLPHPRLHERA
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCEEECCCCCCCCCCCCCCCC
FVLVPLCDLVPQGRHPLLGRTFAELLAGLDPSGVRPYVV
EEEEEHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]