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The map label for this gene is algA [H]

Identifier: 55981719

GI number: 55981719

Start: 1638169

End: 1639182

Strand: Reverse

Name: algA [H]

Synonym: TTHA1750

Alternate gene names: 55981719

Gene position: 1639182-1638169 (Counterclockwise)

Preceding gene: 55981720

Following gene: 55981718

Centisome position: 88.62

GC content: 71.7

Gene sequence:

>1014_bases
GTGAAGACCTACGCCCTGGTGATGGCGGGCGGACGCGGGGAGAGGCTTTGGCCCCTCTCCCGGGAGGACCGCCCCAAGCC
CTTTCTGCCCCTCTTTGAGGGGAAGACCCTCCTCGAGGCCACCCTGGAGCGCCTCGCCCCCCTCGTGCCTCCAGAGCGCA
CCCTCCTCGCCGTGCGCCGGGACCAGGAGGCGGTGGCCCGTCCCTATGCGGACGGGATCCGGCTCCTCCTGGAGCCCTTG
GGCCGGGACACCGCGGGGGCGGTGCTCTTAGGGGTGGCCGAGGCCCTGAAGGAGGGGGCCGAGCGGCTCCTCGTCCTCCC
CGCCGACCACTACGTGGGGGACGACGAGGCCTACCGGGAGGCCTTGGCCACCATGCTGGAGGCGGCGGAGGAGGGTTTTG
TGGTGGCCCTGGGCCTGAGGCCCACCCGCCCGGAGACGGAGTACGGCTACATCCGTCTGGGGCCCAGGGAGGGGGCCTGG
TACCGGGGGGAGGGGTTCGTGGAGAAGCCCTCCTACGCCGAGGCCCTGGAGTACATCCGCAAGGGCTACGTCTGGAACGG
CGGGGTCTTCGCCTTCGCCCCCGCCACCATGGCCGAGCTCTTCCGGCGCCACCTCCCGAGCCACCACGAGGCCCTGGAGC
GCCTCCTCGCCGGGGCCTCCCTGGAGGAGGTGTACGCCGGCCTCCCCAAGATCTCCATTGACTACGGGGTGATGGAGAAG
GCGGAGAGGGTGCGGGTGGTCCTCGGCCGCTTCCCCTGGGACGATGTGGGGAACTGGCGGGCCCTGGAGCGGGTCTTCTC
CCAGGACCCCCACGAGAACGTGGTCCTGGGGGAGGGGCGGCACGTGGCCCTGGACACCTTTGGGTGCGTGGTCTACGCCG
ACCGGGGCGTGGTGGCCACCCTGGGGGTTTCCGGGCTGGTGGTGGCCAAGGTGGGGGACGAGGTCCTGGTGGTGCCCAAG
GACTGGGCCCGGGAGGTGCGGGAGGTGGTGAAACGCCTCGAGGCCCAGGAATGA

Upstream 100 bases:

>100_bases
GCCTGGACCGCTGGGCCATCCGTCGCTACGCGGAGGCCCGCTTCTCCCGGGAACGCATGGCCCGGGACTACCTGGAGCTT
TACCGAAAGGTGGTGGGAGC

Downstream 100 bases:

>100_bases
CGGCCTACGTGGCCTTGGGCTCCAACCTCGGGGACCGCGCGGCCTACCTCTTGGAGGGGCTTTCCCGGCTCTCCCGCCTC
CCCGAAACCCGCCTCCTCCG

Product: mannose-1-phosphate guanylyl transferase (GDP)/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKTYALVMAGGRGERLWPLSREDRPKPFLPLFEGKTLLEATLERLAPLVPPERTLLAVRRDQEAVARPYADGIRLLLEPL
GRDTAGAVLLGVAEALKEGAERLLVLPADHYVGDDEAYREALATMLEAAEEGFVVALGLRPTRPETEYGYIRLGPREGAW
YRGEGFVEKPSYAEALEYIRKGYVWNGGVFAFAPATMAELFRRHLPSHHEALERLLAGASLEEVYAGLPKISIDYGVMEK
AERVRVVLGRFPWDDVGNWRALERVFSQDPHENVVLGEGRHVALDTFGCVVYADRGVVATLGVSGLVVAKVGDEVLVVPK
DWAREVREVVKRLEAQE

Sequences:

>Translated_337_residues
MKTYALVMAGGRGERLWPLSREDRPKPFLPLFEGKTLLEATLERLAPLVPPERTLLAVRRDQEAVARPYADGIRLLLEPL
GRDTAGAVLLGVAEALKEGAERLLVLPADHYVGDDEAYREALATMLEAAEEGFVVALGLRPTRPETEYGYIRLGPREGAW
YRGEGFVEKPSYAEALEYIRKGYVWNGGVFAFAPATMAELFRRHLPSHHEALERLLAGASLEEVYAGLPKISIDYGVMEK
AERVRVVLGRFPWDDVGNWRALERVFSQDPHENVVLGEGRHVALDTFGCVVYADRGVVATLGVSGLVVAKVGDEVLVVPK
DWAREVREVVKRLEAQE
>Mature_337_residues
MKTYALVMAGGRGERLWPLSREDRPKPFLPLFEGKTLLEATLERLAPLVPPERTLLAVRRDQEAVARPYADGIRLLLEPL
GRDTAGAVLLGVAEALKEGAERLLVLPADHYVGDDEAYREALATMLEAAEEGFVVALGLRPTRPETEYGYIRLGPREGAW
YRGEGFVEKPSYAEALEYIRKGYVWNGGVFAFAPATMAELFRRHLPSHHEALERLLAGASLEEVYAGLPKISIDYGVMEK
AERVRVVLGRFPWDDVGNWRALERVFSQDPHENVVLGEGRHVALDTFGCVVYADRGVVATLGVSGLVVAKVGDEVLVVPK
DWAREVREVVKRLEAQE

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=355, Percent_Identity=34.0845070422535, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 37439; Mature: 37439

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYALVMAGGRGERLWPLSREDRPKPFLPLFEGKTLLEATLERLAPLVPPERTLLAVRR
CCEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHEEEECC
DQEAVARPYADGIRLLLEPLGRDTAGAVLLGVAEALKEGAERLLVLPADHYVGDDEAYRE
CHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
ALATMLEAAEEGFVVALGLRPTRPETEYGYIRLGPREGAWYRGEGFVEKPSYAEALEYIR
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHHHH
KGYVWNGGVFAFAPATMAELFRRHLPSHHEALERLLAGASLEEVYAGLPKISIDYGVMEK
HCCEECCCEEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCCCCEEECHHHHHH
AERVRVVLGRFPWDDVGNWRALERVFSQDPHENVVLGEGRHVALDTFGCVVYADRGVVAT
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEECCCCEEEEEECCEEEEECCCEEEE
LGVSGLVVAKVGDEVLVVPKDWAREVREVVKRLEAQE
CCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTYALVMAGGRGERLWPLSREDRPKPFLPLFEGKTLLEATLERLAPLVPPERTLLAVRR
CCEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHEEEECC
DQEAVARPYADGIRLLLEPLGRDTAGAVLLGVAEALKEGAERLLVLPADHYVGDDEAYRE
CHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
ALATMLEAAEEGFVVALGLRPTRPETEYGYIRLGPREGAWYRGEGFVEKPSYAEALEYIR
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHHHH
KGYVWNGGVFAFAPATMAELFRRHLPSHHEALERLLAGASLEEVYAGLPKISIDYGVMEK
HCCEECCCEEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCCCCEEECHHHHHH
AERVRVVLGRFPWDDVGNWRALERVFSQDPHENVVLGEGRHVALDTFGCVVYADRGVVAT
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEECCCCEEEEEECCEEEEECCCEEEE
LGVSGLVVAKVGDEVLVVPKDWAREVREVVKRLEAQE
CCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]