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The map label for this gene is kbl [C]

Identifier: 55981551

GI number: 55981551

Start: 1505012

End: 1506199

Strand: Direct

Name: kbl [C]

Synonym: TTHA1582

Alternate gene names: 55981551

Gene position: 1505012-1506199 (Clockwise)

Preceding gene: 55981532

Following gene: 55981552

Centisome position: 81.36

GC content: 68.01

Gene sequence:

>1188_bases
ATGAGCCTGGATCTGCGCGCACGCGTCCGCGAGGAGCTGGAAAGGCTCAAGCGGGAGGGGCTTTACATCTCCCCCAAGGT
CCTCGAGGCCCCCCAGGAGCCCGTGACCCGGGTGGAGGGGCGGGAGGTGGTGAACCTCGCCTCCAACAACTACCTCGGCT
TCGCCAACCACCCCTACCTCAAGGAGAAGGCCCGCCAGTACCTGGAGAAGTGGGGGGCGGGAAGCGGGGCGGTGCGCACC
ATCGCCGGCACCTTCACCTACCACGTGGAGCTGGAGGAGGCCCTGGCCCGCTTCAAGGGGACGGAAAGCGCCCTCGTCCT
CCAGTCGGGCTTCACCGCCAACCAGGGGGTGCTGGGGGCCCTCCTCAAGGAGGGGGACGTGGTCTTCTCCGACGAGCTGA
ACCACGCCAGCATCATCGACGGCCTCCGCCTCACCAAGGCCACCCGGCTGGTCTTTCGCCACGCGGACGTGGCCCACCTG
GAGGAGCTCCTCAAGGCCCACGACACCGACGGGCTCAAGCTCATCGTCACCGACGGGGTCTTCTCCATGGACGGGGACAT
CGCCCCCCTGGACAAGATCGTCCCCCTGGCCAAGAAGTACAAAGCGGTGGTCTACGTGGACGACGCCCACGGCTCGGGCG
TCCTCGGGGAAAAGGGGAAGGGCACGGTCCACCACTTCGGCTTCCACCAGGACCCCGACGTCGTCCAGGTGGCCACCCTC
TCCAAGGCCTGGGCGGGGATCGGGGGGTACGCCGCGGGGGCCCGGGAGCTCAAGGACCTCCTCATCAACAAGGCCAGGCC
CTTCCTCTTCTCCACAAGCCACCCCCCGGCGGTGGTGGGGGCGCTTCTGGGAGCGCTGGAGCTCATAGAGAAGGAGCCCG
AGCGGGTGGAGCGGCTCTGGGAGAACACCCGCTACTTCAAGCGGGAGCTCGCCCGTCTGGGCTACGACACCCTGGGGAGC
CAGACCCCCATCACCCCCGTCCTCTTCGGGGAGGCCCCCCTGGCCTTTGAGGCGAGCCGCCTCCTCCTGGAGGAGGGGGT
CTTCGCCGTGGGCATCGGCTTCCCCACCGTGCCCAGGGGGAAGGCGAGGATCCGCAACATCGTCACCGCCGCCCACACGA
AGGAGATGCTGGACAAGGCCCTCGAGGCCTACGAGAAGGTGGGCAAGAGGCTCGGTATAATCCGCTAA

Upstream 100 bases:

>100_bases
TCATGGAACCGCTACCACCCCCATCCCTAGGGTAGCGCCTTTCGGTCAGAGGAAGGTGAGCCCCTGGACAGTCCCGGGGC
CCAGGCGGTTAGATAAGGCC

Downstream 100 bases:

>100_bases
GATGCTCTTTCCTCCTTCCCTACCCCCTACGGCCTCCGGGCGAAGCCTGGGCCGAGTAGAAACCCCACCAGGGCTAGTGC
GCTTCATGGTGGGGCTCGCC

Product: 2-amino-3-ketobutyrate CoA ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; Glycine acetyltransferase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSLDLRARVREELERLKREGLYISPKVLEAPQEPVTRVEGREVVNLASNNYLGFANHPYLKEKARQYLEKWGAGSGAVRT
IAGTFTYHVELEEALARFKGTESALVLQSGFTANQGVLGALLKEGDVVFSDELNHASIIDGLRLTKATRLVFRHADVAHL
EELLKAHDTDGLKLIVTDGVFSMDGDIAPLDKIVPLAKKYKAVVYVDDAHGSGVLGEKGKGTVHHFGFHQDPDVVQVATL
SKAWAGIGGYAAGARELKDLLINKARPFLFSTSHPPAVVGALLGALELIEKEPERVERLWENTRYFKRELARLGYDTLGS
QTPITPVLFGEAPLAFEASRLLLEEGVFAVGIGFPTVPRGKARIRNIVTAAHTKEMLDKALEAYEKVGKRLGIIR

Sequences:

>Translated_395_residues
MSLDLRARVREELERLKREGLYISPKVLEAPQEPVTRVEGREVVNLASNNYLGFANHPYLKEKARQYLEKWGAGSGAVRT
IAGTFTYHVELEEALARFKGTESALVLQSGFTANQGVLGALLKEGDVVFSDELNHASIIDGLRLTKATRLVFRHADVAHL
EELLKAHDTDGLKLIVTDGVFSMDGDIAPLDKIVPLAKKYKAVVYVDDAHGSGVLGEKGKGTVHHFGFHQDPDVVQVATL
SKAWAGIGGYAAGARELKDLLINKARPFLFSTSHPPAVVGALLGALELIEKEPERVERLWENTRYFKRELARLGYDTLGS
QTPITPVLFGEAPLAFEASRLLLEEGVFAVGIGFPTVPRGKARIRNIVTAAHTKEMLDKALEAYEKVGKRLGIIR
>Mature_394_residues
SLDLRARVREELERLKREGLYISPKVLEAPQEPVTRVEGREVVNLASNNYLGFANHPYLKEKARQYLEKWGAGSGAVRTI
AGTFTYHVELEEALARFKGTESALVLQSGFTANQGVLGALLKEGDVVFSDELNHASIIDGLRLTKATRLVFRHADVAHLE
ELLKAHDTDGLKLIVTDGVFSMDGDIAPLDKIVPLAKKYKAVVYVDDAHGSGVLGEKGKGTVHHFGFHQDPDVVQVATLS
KAWAGIGGYAAGARELKDLLINKARPFLFSTSHPPAVVGALLGALELIEKEPERVERLWENTRYFKRELARLGYDTLGSQ
TPITPVLFGEAPLAFEASRLLLEEGVFAVGIGFPTVPRGKARIRNIVTAAHTKEMLDKALEAYEKVGKRLGIIR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide. It also converts 2-amino-3- ketobutyrate to glycine and acetyl-CoA. Activity is also observed with the follo

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=388, Percent_Identity=42.2680412371134, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI284448556, Length=414, Percent_Identity=39.6135265700483, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=37.431693989071, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=35.4054054054054, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI83977442, Length=360, Percent_Identity=34.7222222222222, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI83977444, Length=360, Percent_Identity=34.7222222222222, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI83977440, Length=360, Percent_Identity=34.7222222222222, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4502025, Length=361, Percent_Identity=32.9639889196676, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI40316939, Length=361, Percent_Identity=32.9639889196676, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI5454084, Length=278, Percent_Identity=33.8129496402878, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1790046, Length=391, Percent_Identity=41.6879795396419, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=35.5491329479769, Blast_Score=197, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=391, Percent_Identity=41.9437340153453, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=30.9782608695652, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17560912, Length=374, Percent_Identity=31.5508021390374, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=374, Percent_Identity=31.5508021390374, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI71982617, Length=294, Percent_Identity=30.952380952381, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71982625, Length=294, Percent_Identity=30.952380952381, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320438, Length=381, Percent_Identity=33.0708661417323, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=33.5135135135135, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6323954, Length=391, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24662918, Length=397, Percent_Identity=42.3173803526448, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17137420, Length=389, Percent_Identity=34.4473007712082, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=35.8490566037736, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24653280, Length=321, Percent_Identity=30.2180685358255, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24653276, Length=321, Percent_Identity=30.2180685358255, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24653278, Length=321, Percent_Identity=30.2180685358255, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_THET8 (Q5SHZ8)

Other databases:

- EMBL:   AP008226
- RefSeq:   YP_144848.1
- HSSP:   P0AB77
- ProteinModelPortal:   Q5SHZ8
- SMR:   Q5SHZ8
- STRING:   Q5SHZ8
- GeneID:   3169187
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA1582
- NMPDR:   fig|300852.3.peg.1894
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   SGFTANQ
- ProtClustDB:   CLSK445542
- BioCyc:   TTHE300852:TTHA1582-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR13693:SF15
- TIGRFAMs:   TIGR00858
- TIGRFAMs:   TIGR01825

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 43362; Mature: 43231

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 135-135 BINDING 182-182 BINDING 356-356

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDLRARVREELERLKREGLYISPKVLEAPQEPVTRVEGREVVNLASNNYLGFANHPYL
CCCCHHHHHHHHHHHHHHCCCEECHHHHCCCCHHHHHCCCCCEEEECCCCEECCCCCCHH
KEKARQYLEKWGAGSGAVRTIAGTFTYHVELEEALARFKGTESALVLQSGFTANQGVLGA
HHHHHHHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
LLKEGDVVFSDELNHASIIDGLRLTKATRLVFRHADVAHLEELLKAHDTDGLKLIVTDGV
HHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCE
FSMDGDIAPLDKIVPLAKKYKAVVYVDDAHGSGVLGEKGKGTVHHFGFHQDPDVVQVATL
EECCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCEEHHHH
SKAWAGIGGYAAGARELKDLLINKARPFLFSTSHPPAVVGALLGALELIEKEPERVERLW
HHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHH
ENTRYFKRELARLGYDTLGSQTPITPVLFGEAPLAFEASRLLLEEGVFAVGIGFPTVPRG
HHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCH
KARIRNIVTAAHTKEMLDKALEAYEKVGKRLGIIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLDLRARVREELERLKREGLYISPKVLEAPQEPVTRVEGREVVNLASNNYLGFANHPYL
CCCHHHHHHHHHHHHHHCCCEECHHHHCCCCHHHHHCCCCCEEEECCCCEECCCCCCHH
KEKARQYLEKWGAGSGAVRTIAGTFTYHVELEEALARFKGTESALVLQSGFTANQGVLGA
HHHHHHHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
LLKEGDVVFSDELNHASIIDGLRLTKATRLVFRHADVAHLEELLKAHDTDGLKLIVTDGV
HHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCE
FSMDGDIAPLDKIVPLAKKYKAVVYVDDAHGSGVLGEKGKGTVHHFGFHQDPDVVQVATL
EECCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCEEHHHH
SKAWAGIGGYAAGARELKDLLINKARPFLFSTSHPPAVVGALLGALELIEKEPERVERLW
HHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHH
ENTRYFKRELARLGYDTLGSQTPITPVLFGEAPLAFEASRLLLEEGVFAVGIGFPTVPRG
HHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCH
KARIRNIVTAAHTKEMLDKALEAYEKVGKRLGIIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA