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The map label for this gene is tthHB8IM

Identifier: 55981552

GI number: 55981552

Start: 1506201

End: 1507487

Strand: Direct

Name: tthHB8IM

Synonym: TTHA1583

Alternate gene names: 55981552

Gene position: 1506201-1507487 (Clockwise)

Preceding gene: 55981551

Following gene: 55981553

Centisome position: 81.43

GC content: 60.3

Gene sequence:

>1287_bases
ATGCTCTTTCCTCCTTCCCTACCCCCTACGGCCTCCGGGCGAAGCCTGGGCCGAGTAGAAACCCCACCAGGGCTAGTGCG
CTTCATGGTGGGGCTCGCCGAGGCCCCGAAAGGGGGAAGGGTCCTGGAACCCGCCTGCGCGGACGGGCCCTTCCTCCGGG
CCTTCCGGGAGGCCCACGGGACGGGCTACCGCTTCGTGGGGGTGGAGATCGACCCACACGCCCTGGACCTTCCCCCTTGG
GCGGAAGGGGTGGTGGCGGACTTCCTCCTCTGGGAGCCCGGGGAAGCCTTTGACCTCATCTTGGGCAACCCGCCCTACGG
CATCGTGGGGGAGGCCAGCAAGTACCCCATCCACGTCCTTAGGGAGGTCAAGGGGCTTTACAAGAAGACCCTATCCACCT
GGAAGGGCAAGTACAACCTTTACGGGGCCTTCATAGAGAAATCTGTGCGCCTCTTGAGGGAGGGCGGAACCCTGGTCTTC
GTAGTCCCGGCCACGTGGCTCGTCCTGGACGACTTTTCCCTCCTTCGGTCATTTCTGGCCCGAGAAGGGAGAACAGAAGT
TTACTATCTAGGCGAGGTCTTCCCCGGAAGAAAGGTGAGCGCTGTGGTTCTTCGGTTCCGGAAGGGAGGAAAAGGCCTCG
CCCTTTGGGACACCCGGAGAGACGGGGAGACCTTCACGCCCCTCTTGTGGAGCGAGAAGCCGGAATGGAAGGGAGAGATC
ATCCGCTTCGAAACAGGGTGGACCAGGGAGATGGAGGCCTCGGGTCCACCCCTAGGTAGCCTATTCCACATCCGCTTCGC
CGCCAGGAGCCCGGAGTTCAAGAAGCATCCCGCCGTCCAAAAGGAACCGGAACCTGGCCTTGTGCCCGTCCTGACGGGAA
GGAACCTGAAGCCGGGGTGGATAGACTACGAAAGCAACCACTCCGGCCTTTGGATGCCCAAGGAAAGGGCCAAGGAGCTT
AGGGACTTCTACGCCACGCCCCACTTGGTGGTGGCCCACACTAAGGGCACCAAGGTGGTAGCCGCTTGGGACGAGAAGGC
CTACCCGTGGAGAGAAGAGTTCCACCTTCTGCCCAAGGAGGGTGTGGAACTAGACCCCTTGTTTCTGGTAGAGTGGTTAA
ACTCCGATAAGATACAAGAGTATGTCAAAACCCTTTACAGGGACTTTGTTCCTCACTTGACGCTTAGAATGTTGGAGCGG
ATACCTGCGTTGCTTCCCCGAAAGGGGAACACCGAGAGGAGGAAACATGGCCCCTACACAAGCCCAGAAAGTGCTGGAAG
CTTTTGA

Upstream 100 bases:

>100_bases
ATCCGCAACATCGTCACCGCCGCCCACACGAAGGAGATGCTGGACAAGGCCCTCGAGGCCTACGAGAAGGTGGGCAAGAG
GCTCGGTATAATCCGCTAAG

Downstream 100 bases:

>100_bases
GGATTTTCTGAAGTGTTTGGACCTCGAGAGCTACCAAGAAAAATACCGCCCCATCAAAACAGTAGAGCAAGACCTACCTA
GAGAGCTTAACCCACTTCCA

Product: adenine-specific DNA-methyltransferase

Products: NA

Alternate protein names: M.TthHB8I; Adenine-specific methyltransferase TthHB8I

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLFPPSLPPTASGRSLGRVETPPGLVRFMVGLAEAPKGGRVLEPACADGPFLRAFREAHGTGYRFVGVEIDPHALDLPPW
AEGVVADFLLWEPGEAFDLILGNPPYGIVGEASKYPIHVLREVKGLYKKTLSTWKGKYNLYGAFIEKSVRLLREGGTLVF
VVPATWLVLDDFSLLRSFLAREGRTEVYYLGEVFPGRKVSAVVLRFRKGGKGLALWDTRRDGETFTPLLWSEKPEWKGEI
IRFETGWTREMEASGPPLGSLFHIRFAARSPEFKKHPAVQKEPEPGLVPVLTGRNLKPGWIDYESNHSGLWMPKERAKEL
RDFYATPHLVVAHTKGTKVVAAWDEKAYPWREEFHLLPKEGVELDPLFLVEWLNSDKIQEYVKTLYRDFVPHLTLRMLER
IPALLPRKGNTERRKHGPYTSPESAGSF

Sequences:

>Translated_428_residues
MLFPPSLPPTASGRSLGRVETPPGLVRFMVGLAEAPKGGRVLEPACADGPFLRAFREAHGTGYRFVGVEIDPHALDLPPW
AEGVVADFLLWEPGEAFDLILGNPPYGIVGEASKYPIHVLREVKGLYKKTLSTWKGKYNLYGAFIEKSVRLLREGGTLVF
VVPATWLVLDDFSLLRSFLAREGRTEVYYLGEVFPGRKVSAVVLRFRKGGKGLALWDTRRDGETFTPLLWSEKPEWKGEI
IRFETGWTREMEASGPPLGSLFHIRFAARSPEFKKHPAVQKEPEPGLVPVLTGRNLKPGWIDYESNHSGLWMPKERAKEL
RDFYATPHLVVAHTKGTKVVAAWDEKAYPWREEFHLLPKEGVELDPLFLVEWLNSDKIQEYVKTLYRDFVPHLTLRMLER
IPALLPRKGNTERRKHGPYTSPESAGSF
>Mature_428_residues
MLFPPSLPPTASGRSLGRVETPPGLVRFMVGLAEAPKGGRVLEPACADGPFLRAFREAHGTGYRFVGVEIDPHALDLPPW
AEGVVADFLLWEPGEAFDLILGNPPYGIVGEASKYPIHVLREVKGLYKKTLSTWKGKYNLYGAFIEKSVRLLREGGTLVF
VVPATWLVLDDFSLLRSFLAREGRTEVYYLGEVFPGRKVSAVVLRFRKGGKGLALWDTRRDGETFTPLLWSEKPEWKGEI
IRFETGWTREMEASGPPLGSLFHIRFAARSPEFKKHPAVQKEPEPGLVPVLTGRNLKPGWIDYESNHSGLWMPKERAKEL
RDFYATPHLVVAHTKGTKVVAAWDEKAYPWREEFHLLPKEGVELDPLFLVEWLNSDKIQEYVKTLYRDFVPHLTLRMLER
IPALLPRKGNTERRKHGPYTSPESAGSF

Specific function: This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the TthHB8I endonuclease

COG id: COG0827

COG function: function code L; Adenine-specific DNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTT8_THET8 (P29749)

Other databases:

- EMBL:   M74795
- EMBL:   AP008226
- PIR:   JH0634
- RefSeq:   YP_144849.1
- ProteinModelPortal:   P29749
- SMR:   P29749
- STRING:   P29749
- REBASE:   3523
- GeneID:   3169149
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA1583
- NMPDR:   fig|300852.3.peg.1895
- eggNOG:   COG0827
- HOGENOM:   HBG414874
- OMA:   PWREEFH
- ProtClustDB:   CLSK738767
- BioCyc:   TTHE300852:TTHA1583-MONOMER
- InterPro:   IPR002052
- InterPro:   IPR002296
- InterPro:   IPR021188
- InterPro:   IPR023135
- InterPro:   IPR011639
- Gene3D:   G3DSA:3.90.220.10
- PIRSF:   PIRSF037236
- PRINTS:   PR00507

Pfam domain/function: PF07669 Eco57I

EC number: =2.1.1.72

Molecular weight: Translated: 48408; Mature: 48408

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFPPSLPPTASGRSLGRVETPPGLVRFMVGLAEAPKGGRVLEPACADGPFLRAFREAHG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCC
TGYRFVGVEIDPHALDLPPWAEGVVADFLLWEPGEAFDLILGNPPYGIVGEASKYPIHVL
CCEEEEEEEECCCCCCCCCCHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCHHHHH
REVKGLYKKTLSTWKGKYNLYGAFIEKSVRLLREGGTLVFVVPATWLVLDDFSLLRSFLA
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCEEEHHHHHHHHHHHH
REGRTEVYYLGEVFPGRKVSAVVLRFRKGGKGLALWDTRRDGETFTPLLWSEKPEWKGEI
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCE
IRFETGWTREMEASGPPLGSLFHIRFAARSPEFKKHPAVQKEPEPGLVPVLTGRNLKPGW
EEEECCCCEECCCCCCCCCCEEEEEEECCCCCHHCCCCCCCCCCCCEEEEECCCCCCCCE
IDYESNHSGLWMPKERAKELRDFYATPHLVVAHTKGTKVVAAWDEKAYPWREEFHLLPKE
EEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCHHHHCCCCCC
GVELDPLFLVEWLNSDKIQEYVKTLYRDFVPHLTLRMLERIPALLPRKGNTERRKHGPYT
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
SPESAGSF
CCCCCCCC
>Mature Secondary Structure
MLFPPSLPPTASGRSLGRVETPPGLVRFMVGLAEAPKGGRVLEPACADGPFLRAFREAHG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCC
TGYRFVGVEIDPHALDLPPWAEGVVADFLLWEPGEAFDLILGNPPYGIVGEASKYPIHVL
CCEEEEEEEECCCCCCCCCCHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCHHHHH
REVKGLYKKTLSTWKGKYNLYGAFIEKSVRLLREGGTLVFVVPATWLVLDDFSLLRSFLA
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCEEEHHHHHHHHHHHH
REGRTEVYYLGEVFPGRKVSAVVLRFRKGGKGLALWDTRRDGETFTPLLWSEKPEWKGEI
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCE
IRFETGWTREMEASGPPLGSLFHIRFAARSPEFKKHPAVQKEPEPGLVPVLTGRNLKPGW
EEEECCCCEECCCCCCCCCCEEEEEEECCCCCHHCCCCCCCCCCCCEEEEECCCCCCCCE
IDYESNHSGLWMPKERAKELRDFYATPHLVVAHTKGTKVVAAWDEKAYPWREEFHLLPKE
EEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCHHHHCCCCCC
GVELDPLFLVEWLNSDKIQEYVKTLYRDFVPHLTLRMLERIPALLPRKGNTERRKHGPYT
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
SPESAGSF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339363