BacMap

Definition	Thermus thermophilus HB8 chromosome, complete genome.
Accession	NC_006461
Length	1,849,742

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The map label for this gene is ftsH

Identifier: 55981461

GI number: 55981461

Start: 1419132

End: 1421006

Strand: Direct

Name: ftsH

Synonym: TTHA1492

Alternate gene names: 55981461

Gene position: 1419132-1421006 (Clockwise)

Preceding gene: 55981440

Following gene: 55981463

Centisome position: 76.72

GC content: 70.45

Gene sequence:

>1875_bases
ATGCCTCGAGCCCCCTTTAGCCTTCTCGCCCTGGTCCTGGGCCTCGCCTTCCTGGCCTGGGCCTTCAGCCTCGCGGGCAC
CGTGGGCGCCCCAAGCGGGACGGTGAACTACACGACCTTCCTGGAGGACCTCAAGGCGGGCCGGGTCAAGGAGGTGGTGG
TGCGCGCCGGGGACACCCGGATCCAGGGGGTCCTGGAGGACGGCTCCGCCTTCACCACCTACGCGGCGAGCCCTCCGGAC
AACGCCACCCTCGAGGGCTGGATGGCCCGGGGGGTGAGCGTCCGGGTGGAGCCCCCCCAGGGCCAAAACGCCCTCGGCTT
CCTCTGGCCCCTCCTCCTCGTGGGCCTCCTCATCGGCGCCCTCTACTACTTCTCCCGCAACGGCCGGGCCGGGCCTTCGG
ACTCCGCCTTCAGCTTCACCAAAAGCCGGGCCCGGGTCCTCACCGAGGCCCCCAAGGTCACCTTCAAGGACGTGGCCGGG
GCGGAGGAGGCCAAGGAGGAACTCAAGGAGATCGTGGAGTTCCTCAAAAACCCCAGCCGCTTCCACGAGATGGGCGCCCG
CATCCCCAAGGGTGTCCTCCTGGTGGGGCCCCCGGGGGTGGGCAAGACCCACCTGGCCCGGGCCGTGGCCGGGGAGGCCC
GGGTGCCCTTCATCACCGCCTCGGGCTCCGACTTCGTGGAGATGTTCGTGGGGGTAGGGGCGGCGAGGGTCCGGGACCTC
TTTGAGACCGCCAAGCGCCACGCCCCCTGCATCGTCTTCATTGACGAGATTGACGCCGTGGGGAGGAAGCGGGGAAGCGG
GGTGGGGGGCGGGAACGACGAGCGGGAGCAGACCCTGAACCAGCTCCTCGTGGAGATGGACGGCTTTGAGAAGGACACGG
CCATCGTGGTCATGGCCGCCACCAACCGCCCCGACATCCTGGACCCCGCCCTGCTCCGCCCCGGGCGCTTTGACCGGCAG
ATCGCCATAGACGCCCCCGACGTCAAGGGCCGGGAGCAGATCCTCAGGATCCACGCCCGGGGCAAGCCCCTGGCGGAGGA
CGTGGACCTGGCCCTCCTCGCCAAGCGCACCCCGGGCTTCGTGGGGGCGGACCTGGAGAACCTCCTGAACGAAGCCGCCC
TCCTCGCCGCCCGGGAGGGGCGGAGGAAGATCACCATGAAGGACCTGGAGGAGGCCGCCGACCGGGTGATGATGGGCCCG
GCCAAGAAAAGCCTCGTCCTCTCCCCCCGCGACCGCAGGATCACCGCCTACCACGAGGCGGGGCACGCCCTGGCGGCCCA
CTTCCTGGAGCACGCCGACGGGGTGCACAAGGTGACCATCGTGCCCCGGGGAAGGGCCTTGGGCTTCATGATGCCCAGGC
GGGAGGACATGCTCCACTGGTCCAGAAAGCGCCTTTTGGACCAGATCGCCGTGGCCCTGGCGGGGCGGGCGGCGGAGGAG
ATCGTCTTTGACGACGTGACCACGGGGGCGGAGAACGACTTCCGCCAGGCCACGGAGCTCGCCCGCCGCATGATCACCGA
GTGGGGGATGCACCCCGAGTTCGGCCCCGTGGCCTACGCGGTGCGGGAGGACACCTACCTGGGCGGCTACGACGTGCGCC
AGTACTCGGAGGAGACCGCCAAGCGCATTGACGAGGCGGTGCGCCGCCTCATTGAGGAGCAGTACCAGAGGGTGAAGGCC
CTTCTCCTGGAAAAGCGGGAGGTCCTGGAGCGGGTGGCGGAGACCCTCCTGGAGCGGGAGACCCTCACCGCCGAGGAGTT
CCAACGGGTGGTGGAGGGGCTCCCCTTGGAGGCCCCCGAGGAGGCCCGGGAGGAGCGGGAGCCCCCCCGGGTGGTGCCCA
AGGTGAAGCCGGGGGGCGCCCTGGGCGGGGCCTGA

Upstream 100 bases:

>100_bases
GCCGCATTTTTGTCAAGGGAGTTGAGTATGATTTTGTCATGGTCGGTTGGTGAGGCGGCCTACCCTTTTTCCCTCCCCCC
GGTGTACCTTGAAGGAAGAC

Downstream 100 bases:

>100_bases
GGCCCCGGCGAGGGCCACGGGAAGGCCCCACGCGGGCTTGCGCCCGCGTGGGGCGGTATCAGAGGGGGTCGTCCTGGAGG
ACGAGGGTCTTGAGGTAGAG

Product: cell division protein FtsH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MPRAPFSLLALVLGLAFLAWAFSLAGTVGAPSGTVNYTTFLEDLKAGRVKEVVVRAGDTRIQGVLEDGSAFTTYAASPPD
NATLEGWMARGVSVRVEPPQGQNALGFLWPLLLVGLLIGALYYFSRNGRAGPSDSAFSFTKSRARVLTEAPKVTFKDVAG
AEEAKEELKEIVEFLKNPSRFHEMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFVEMFVGVGAARVRDL
FETAKRHAPCIVFIDEIDAVGRKRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAATNRPDILDPALLRPGRFDRQ
IAIDAPDVKGREQILRIHARGKPLAEDVDLALLAKRTPGFVGADLENLLNEAALLAAREGRRKITMKDLEEAADRVMMGP
AKKSLVLSPRDRRITAYHEAGHALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALAGRAAEE
IVFDDVTTGAENDFRQATELARRMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETAKRIDEAVRRLIEEQYQRVKA
LLLEKREVLERVAETLLERETLTAEEFQRVVEGLPLEAPEEAREEREPPRVVPKVKPGGALGGA

Sequences:

>Translated_624_residues
MPRAPFSLLALVLGLAFLAWAFSLAGTVGAPSGTVNYTTFLEDLKAGRVKEVVVRAGDTRIQGVLEDGSAFTTYAASPPD
NATLEGWMARGVSVRVEPPQGQNALGFLWPLLLVGLLIGALYYFSRNGRAGPSDSAFSFTKSRARVLTEAPKVTFKDVAG
AEEAKEELKEIVEFLKNPSRFHEMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFVEMFVGVGAARVRDL
FETAKRHAPCIVFIDEIDAVGRKRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAATNRPDILDPALLRPGRFDRQ
IAIDAPDVKGREQILRIHARGKPLAEDVDLALLAKRTPGFVGADLENLLNEAALLAAREGRRKITMKDLEEAADRVMMGP
AKKSLVLSPRDRRITAYHEAGHALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALAGRAAEE
IVFDDVTTGAENDFRQATELARRMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETAKRIDEAVRRLIEEQYQRVKA
LLLEKREVLERVAETLLERETLTAEEFQRVVEGLPLEAPEEAREEREPPRVVPKVKPGGALGGA
>Mature_623_residues
PRAPFSLLALVLGLAFLAWAFSLAGTVGAPSGTVNYTTFLEDLKAGRVKEVVVRAGDTRIQGVLEDGSAFTTYAASPPDN
ATLEGWMARGVSVRVEPPQGQNALGFLWPLLLVGLLIGALYYFSRNGRAGPSDSAFSFTKSRARVLTEAPKVTFKDVAGA
EEAKEELKEIVEFLKNPSRFHEMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFVEMFVGVGAARVRDLF
ETAKRHAPCIVFIDEIDAVGRKRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAATNRPDILDPALLRPGRFDRQI
AIDAPDVKGREQILRIHARGKPLAEDVDLALLAKRTPGFVGADLENLLNEAALLAAREGRRKITMKDLEEAADRVMMGPA
KKSLVLSPRDRRITAYHEAGHALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALAGRAAEEI
VFDDVTTGAENDFRQATELARRMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETAKRIDEAVRRLIEEQYQRVKAL
LLEKREVLERVAETLLERETLTAEEFQRVVEGLPLEAPEEAREEREPPRVVPKVKPGGALGGA

Specific function: Degrades preferentially unfolded substrates in a processive, ATP-dependent manner, usually after hydrophobic residues

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cell inner membrane (Probable); Multi-pass membrane protein; Cytoplasmic side

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase M41 family

Homologues:

Organism=Homo sapiens, GI300192933, Length=490, Percent_Identity=51.6326530612245, Blast_Score=474, Evalue=1e-133,
Organism=Homo sapiens, GI21327685, Length=453, Percent_Identity=47.4613686534216, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI7657689, Length=453, Percent_Identity=47.4613686534216, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI4507173, Length=501, Percent_Identity=43.7125748502994, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI4506209, Length=257, Percent_Identity=45.9143968871595, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI24497435, Length=263, Percent_Identity=43.3460076045627, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI24430151, Length=250, Percent_Identity=43.6, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI6005942, Length=232, Percent_Identity=44.3965517241379, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI195539395, Length=246, Percent_Identity=42.2764227642276, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI21361144, Length=253, Percent_Identity=41.897233201581, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI89064750, Length=250, Percent_Identity=41.6, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI5729991, Length=250, Percent_Identity=41.6, Blast_Score=196, Evalue=8e-50,
Organism=Homo sapiens, GI24430155, Length=250, Percent_Identity=41.6, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI45643125, Length=277, Percent_Identity=39.3501805054152, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI45643123, Length=277, Percent_Identity=39.3501805054152, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI157671927, Length=235, Percent_Identity=41.7021276595745, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI40806173, Length=187, Percent_Identity=54.5454545454545, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI229577436, Length=253, Percent_Identity=41.501976284585, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI4505725, Length=226, Percent_Identity=39.3805309734513, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI5901990, Length=271, Percent_Identity=38.7453874538745, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI153792536, Length=233, Percent_Identity=40.343347639485, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI24497618, Length=284, Percent_Identity=38.3802816901408, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI194018488, Length=280, Percent_Identity=37.1428571428571, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI14149767, Length=245, Percent_Identity=39.1836734693878, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI62177112, Length=245, Percent_Identity=39.1836734693878, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI7019569, Length=239, Percent_Identity=37.2384937238494, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI156564401, Length=209, Percent_Identity=41.6267942583732, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI226371754, Length=244, Percent_Identity=34.4262295081967, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI310125280, Length=209, Percent_Identity=41.1483253588517, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI310125282, Length=209, Percent_Identity=41.1483253588517, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI11875211, Length=272, Percent_Identity=36.0294117647059, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI40806170, Length=272, Percent_Identity=36.0294117647059, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI17865802, Length=240, Percent_Identity=37.5, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI31377644, Length=234, Percent_Identity=36.7521367521368, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI31742536, Length=234, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI112789543, Length=234, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI64084766, Length=276, Percent_Identity=27.8985507246377, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI116292174, Length=258, Percent_Identity=29.8449612403101, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4757852, Length=156, Percent_Identity=31.4102564102564, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI119964730, Length=156, Percent_Identity=31.4102564102564, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789568, Length=592, Percent_Identity=50.1689189189189, Blast_Score=566, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71994521, Length=463, Percent_Identity=50.5399568034557, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17554264, Length=461, Percent_Identity=45.5531453362256, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI115534323, Length=453, Percent_Identity=45.0331125827815, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17554786, Length=263, Percent_Identity=45.2471482889734, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI25144278, Length=263, Percent_Identity=44.8669201520913, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI25144281, Length=263, Percent_Identity=44.8669201520913, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17563248, Length=257, Percent_Identity=45.5252918287938, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17532375, Length=249, Percent_Identity=42.1686746987952, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17505546, Length=251, Percent_Identity=45.0199203187251, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17563250, Length=252, Percent_Identity=43.2539682539683, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71987364, Length=252, Percent_Identity=42.8571428571429, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71987372, Length=252, Percent_Identity=42.8571428571429, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17531535, Length=239, Percent_Identity=43.0962343096234, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17508701, Length=254, Percent_Identity=40.9448818897638, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17554784, Length=250, Percent_Identity=41.6, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17508053, Length=238, Percent_Identity=42.0168067226891, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17537217, Length=260, Percent_Identity=39.2307692307692, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI193206116, Length=244, Percent_Identity=40.1639344262295, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI193206114, Length=244, Percent_Identity=40.1639344262295, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI133931034, Length=244, Percent_Identity=40.1639344262295, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI25153574, Length=228, Percent_Identity=36.8421052631579, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI193209502, Length=227, Percent_Identity=36.5638766519824, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562804, Length=253, Percent_Identity=35.9683794466403, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17570397, Length=187, Percent_Identity=47.0588235294118, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32566590, Length=187, Percent_Identity=47.0588235294118, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI86561515, Length=290, Percent_Identity=33.448275862069, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI133901658, Length=209, Percent_Identity=39.2344497607655, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI133901662, Length=209, Percent_Identity=39.2344497607655, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25146157, Length=247, Percent_Identity=38.8663967611336, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32563584, Length=231, Percent_Identity=38.0952380952381, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17508421, Length=231, Percent_Identity=38.0952380952381, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560432, Length=280, Percent_Identity=33.2142857142857, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17541226, Length=229, Percent_Identity=34.061135371179, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17541224, Length=229, Percent_Identity=34.061135371179, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320854, Length=526, Percent_Identity=45.8174904942966, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6323736, Length=489, Percent_Identity=48.6707566462168, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6325281, Length=450, Percent_Identity=43.3333333333333, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321390, Length=253, Percent_Identity=44.6640316205534, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6322704, Length=257, Percent_Identity=44.7470817120623, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6320197, Length=260, Percent_Identity=41.1538461538462, Blast_Score=209, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6324691, Length=264, Percent_Identity=42.0454545454545, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324833, Length=249, Percent_Identity=42.9718875502008, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320077, Length=236, Percent_Identity=41.9491525423729, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320602, Length=262, Percent_Identity=41.9847328244275, Blast_Score=190, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6323429, Length=252, Percent_Identity=40.4761904761905, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6322994, Length=234, Percent_Identity=41.8803418803419, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322651, Length=253, Percent_Identity=36.7588932806324, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321709, Length=269, Percent_Identity=37.546468401487, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324000, Length=249, Percent_Identity=38.5542168674699, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325431, Length=255, Percent_Identity=37.2549019607843, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319554, Length=232, Percent_Identity=37.0689655172414, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6325183, Length=262, Percent_Identity=35.1145038167939, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321465, Length=232, Percent_Identity=36.2068965517241, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320887, Length=255, Percent_Identity=34.9019607843137, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574878, Length=496, Percent_Identity=47.3790322580645, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24665814, Length=496, Percent_Identity=47.3790322580645, Blast_Score=454, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24658770, Length=515, Percent_Identity=43.3009708737864, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24639391, Length=449, Percent_Identity=45.8797327394209, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19920408, Length=261, Percent_Identity=43.6781609195402, Blast_Score=219, Evalue=6e-57,
Organism=Drosophila melanogaster, GI161076488, Length=248, Percent_Identity=43.1451612903226, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17137560, Length=248, Percent_Identity=43.1451612903226, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17137738, Length=257, Percent_Identity=44.7470817120623, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI161076486, Length=248, Percent_Identity=43.1451612903226, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651451, Length=263, Percent_Identity=42.9657794676806, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24649446, Length=252, Percent_Identity=44.4444444444444, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI45554047, Length=165, Percent_Identity=56.3636363636364, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17738151, Length=267, Percent_Identity=40.8239700374532, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI18860063, Length=244, Percent_Identity=42.6229508196721, Blast_Score=196, Evalue=5e-50,
Organism=Drosophila melanogaster, GI281361487, Length=244, Percent_Identity=42.2131147540984, Blast_Score=196, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24640100, Length=245, Percent_Identity=42.4489795918367, Blast_Score=196, Evalue=6e-50,
Organism=Drosophila melanogaster, GI281365776, Length=234, Percent_Identity=42.3076923076923, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24660075, Length=234, Percent_Identity=42.3076923076923, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI45552965, Length=234, Percent_Identity=42.3076923076923, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24652279, Length=190, Percent_Identity=46.8421052631579, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24663015, Length=248, Percent_Identity=41.1290322580645, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI19921202, Length=238, Percent_Identity=39.4957983193277, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24656820, Length=264, Percent_Identity=39.7727272727273, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24656825, Length=264, Percent_Identity=39.7727272727273, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281363136, Length=238, Percent_Identity=38.655462184874, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI78707192, Length=238, Percent_Identity=38.655462184874, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI18859657, Length=239, Percent_Identity=40.5857740585774, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21355121, Length=233, Percent_Identity=35.1931330472103, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24644145, Length=245, Percent_Identity=39.1836734693878, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281360144, Length=245, Percent_Identity=35.9183673469388, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281360140, Length=245, Percent_Identity=35.9183673469388, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281360136, Length=245, Percent_Identity=35.9183673469388, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24644411, Length=245, Percent_Identity=35.9183673469388, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281360146, Length=245, Percent_Identity=35.9183673469388, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281360138, Length=245, Percent_Identity=35.9183673469388, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281360142, Length=245, Percent_Identity=35.9183673469388, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21357333, Length=245, Percent_Identity=35.9183673469388, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28573010, Length=209, Percent_Identity=40.6698564593301, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI17864540, Length=209, Percent_Identity=40.1913875598086, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28571849, Length=274, Percent_Identity=38.3211678832117, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28571847, Length=274, Percent_Identity=38.3211678832117, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI20129423, Length=233, Percent_Identity=35.1931330472103, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI20129529, Length=247, Percent_Identity=34.8178137651822, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24581396, Length=236, Percent_Identity=36.4406779661017, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24639486, Length=200, Percent_Identity=32, Blast_Score=96, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTSH_THET8 (Q5SI82)

Other databases:

- EMBL:   AB032368
- EMBL:   AP008226
- EMBL:   AB012390
- RefSeq:   YP_144758.1
- PDB:   1IXZ
- PDB:   1IY0
- PDB:   1IY1
- PDB:   1IY2
- PDB:   2DHR
- PDBsum:   1IXZ
- PDBsum:   1IY0
- PDBsum:   1IY1
- PDBsum:   1IY2
- PDBsum:   2DHR
- ProteinModelPortal:   Q5SI82
- SMR:   Q5SI82
- STRING:   Q5SI82
- MEROPS:   M41.013
- GeneID:   3170023
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA1492
- eggNOG:   COG0465
- HOGENOM:   HBG724153
- OMA:   YDEYLLA
- ProtClustDB:   CLSK738216
- BioCyc:   TTHE300852:TTHA1492-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01458
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR005936
- InterPro:   IPR011546
- InterPro:   IPR000642
- SMART:   SM00382
- TIGRFAMs:   TIGR01241

Pfam domain/function: PF00004 AAA; PF06480 FtsH_ext; PF01434 Peptidase_M41

EC number: 3.4.24.- [C]

Molecular weight: Translated: 68453; Mature: 68322

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00674 AAA

Important sites: ACT_SITE 419-419 BINDING 159-159 BINDING 204-204

Signals:

None

Transmembrane regions:

HASH(0x14711f0c)-; HASH(0x14986f4c)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRAPFSLLALVLGLAFLAWAFSLAGTVGAPSGTVNYTTFLEDLKAGRVKEVVVRAGDTR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
IQGVLEDGSAFTTYAASPPDNATLEGWMARGVSVRVEPPQGQNALGFLWPLLLVGLLIGA
EEEEEECCCEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
LYYFSRNGRAGPSDSAFSFTKSRARVLTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCHHH
FHEMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFVEMFVGVGAARVRDL
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCHHHHHHH
FETAKRHAPCIVFIDEIDAVGRKRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAA
HHHHHHCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
TNRPDILDPALLRPGRFDRQIAIDAPDVKGREQILRIHARGKPLAEDVDLALLAKRTPGF
CCCCCCCCHHHCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHCCHHHHHCCCCCC
VGADLENLLNEAALLAAREGRRKITMKDLEEAADRVMMGPAKKSLVLSPRDRRITAYHEA
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEHHHH
GHALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALAGRAAEE
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVFDDVTTGAENDFRQATELARRMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETA
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
KRIDEAVRRLIEEQYQRVKALLLEKREVLERVAETLLERETLTAEEFQRVVEGLPLEAPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCH
EAREEREPPRVVPKVKPGGALGGA
HHHHCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
PRAPFSLLALVLGLAFLAWAFSLAGTVGAPSGTVNYTTFLEDLKAGRVKEVVVRAGDTR
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
IQGVLEDGSAFTTYAASPPDNATLEGWMARGVSVRVEPPQGQNALGFLWPLLLVGLLIGA
EEEEEECCCEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
LYYFSRNGRAGPSDSAFSFTKSRARVLTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCHHH
FHEMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFVEMFVGVGAARVRDL
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCHHHHHHH
FETAKRHAPCIVFIDEIDAVGRKRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAA
HHHHHHCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
TNRPDILDPALLRPGRFDRQIAIDAPDVKGREQILRIHARGKPLAEDVDLALLAKRTPGF
CCCCCCCCHHHCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHCCHHHHHCCCCCC
VGADLENLLNEAALLAAREGRRKITMKDLEEAADRVMMGPAKKSLVLSPRDRRITAYHEA
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEHHHH
GHALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALAGRAAEE
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVFDDVTTGAENDFRQATELARRMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETA
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
KRIDEAVRRLIEEQYQRVKALLLEKREVLERVAETLLERETLTAEEFQRVVEGLPLEAPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCH
EAREEREPPRVVPKVKPGGALGGA
HHHHCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10788805; 10377389