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The map label for this gene is sppA [H]

Identifier: 55981463

GI number: 55981463

Start: 1422243

End: 1423148

Strand: Direct

Name: sppA [H]

Synonym: TTHA1494

Alternate gene names: 55981463

Gene position: 1422243-1423148 (Clockwise)

Preceding gene: 55981461

Following gene: 55981464

Centisome position: 76.89

GC content: 72.41

Gene sequence:

>906_bases
ATGAACCGGAAGCGATGGCTCGCCCTCGCCCTCTTCCTCGGCGTGGCCCTTCTGGTGGTGGGGCTGGGCCGGCTCACGGC
GAGCCCCCCCGCCCAAGGCCCCTGGCGGGAGACCACCCTCTACGGCCAGGGGGAGAAGGTCCTGCTTCTGGAGCTTCTCG
GCGAGATCCCCTCGGGCAAGGCCCTGGAGCGCTTCCTCTCCCAGGTGCGCCAGGCCCGGGAGGACGAGGGGGTGCGGGCC
GTGGTCCTCTACGTGGAAAGCCCCGGGGGCGGGGTCACGGAGACCGAGGCCCTGCACCGCGCCCTCCGCGCCCTGGCCCA
GGAGAAGCCCCTGGTGGCCAGCCTCGGAAGGGTGGCGGCGAGCGGCGGCTACTACGTGGCCACCGCCGCCCGGGAGATCC
TCGTCCCCCCCACGGCGGTGACCGGCTCCATCGGGGTGGTGGGCTACCTGCCCCAGGTGGGGGAGCTTTTGGCCAAGGTG
GGCGTCCGGGTGGAGGTGCTCAAGGAGGGGCGGCTCAAGGACATGGCCTCGCCCCTCAGGCCCCTCACCCCGGAGGAGCG
GGAGGTGGTCCAAGGCCTTCTGCGCGAGGCCTACGAGCTTTTCGTCCAGCGGGTGGCGGAGGGGCGGGGGATGCCCCGGG
AGAAGGTCCTCGCCCTCGCCGACGGGCGCATCTACTCGGGGAAGCAGGCCGTGGCCCTGGGCCTCGCCGACCGGGAGGGC
TACCTGGAGGACGCCGCCCGAAGGGCCGCGGAGCTTGCGGGCCTTAAGGCCTTCCGCCTCGTGCGCTACACCAGGCCCAA
AGGCCTCCTGGAGGGGCTTTGGGGCGAGGAGGTTCCCTGGGCCCAGGGCCTTCTCCAGGCGCGCTTTCGCGTAGAATACC
GCTACCTTGGAGGTGGCCTGTGGTGA

Upstream 100 bases:

>100_bases
CGGTAGAGGTTCGGGTAGAAGTTGCGGAGCTTCCGCTCCTTGCCCGCCTTGACCACAAGCCTCAGCACAGGCCCCAGCAT
ACGCCTGCTATAGTGGAGCC

Downstream 100 bases:

>100_bases
TCGCAAGCCCTTGGCGAAGGCTCGTGGCCTCCCTGGTGGACAGCCTCGTCCTCCTCCCCCTAAGCCTCCTCCTCATGGCC
CTGGCGGGGGTGGACCCCCT

Product: protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNRKRWLALALFLGVALLVVGLGRLTASPPAQGPWRETTLYGQGEKVLLLELLGEIPSGKALERFLSQVRQAREDEGVRA
VVLYVESPGGGVTETEALHRALRALAQEKPLVASLGRVAASGGYYVATAAREILVPPTAVTGSIGVVGYLPQVGELLAKV
GVRVEVLKEGRLKDMASPLRPLTPEEREVVQGLLREAYELFVQRVAEGRGMPREKVLALADGRIYSGKQAVALGLADREG
YLEDAARRAAELAGLKAFRLVRYTRPKGLLEGLWGEEVPWAQGLLQARFRVEYRYLGGGLW

Sequences:

>Translated_301_residues
MNRKRWLALALFLGVALLVVGLGRLTASPPAQGPWRETTLYGQGEKVLLLELLGEIPSGKALERFLSQVRQAREDEGVRA
VVLYVESPGGGVTETEALHRALRALAQEKPLVASLGRVAASGGYYVATAAREILVPPTAVTGSIGVVGYLPQVGELLAKV
GVRVEVLKEGRLKDMASPLRPLTPEEREVVQGLLREAYELFVQRVAEGRGMPREKVLALADGRIYSGKQAVALGLADREG
YLEDAARRAAELAGLKAFRLVRYTRPKGLLEGLWGEEVPWAQGLLQARFRVEYRYLGGGLW
>Mature_301_residues
MNRKRWLALALFLGVALLVVGLGRLTASPPAQGPWRETTLYGQGEKVLLLELLGEIPSGKALERFLSQVRQAREDEGVRA
VVLYVESPGGGVTETEALHRALRALAQEKPLVASLGRVAASGGYYVATAAREILVPPTAVTGSIGVVGYLPQVGELLAKV
GVRVEVLKEGRLKDMASPLRPLTPEEREVVQGLLREAYELFVQRVAEGRGMPREKVLALADGRIYSGKQAVALGLADREG
YLEDAARRAAELAGLKAFRLVRYTRPKGLLEGLWGEEVPWAQGLLQARFRVEYRYLGGGLW

Specific function: Digestion of cleaved signal peptides. Required for efficient processing of precursors under conditions of hyper-secretion [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=206, Percent_Identity=37.378640776699, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1787527, Length=158, Percent_Identity=36.0759493670886, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 32772; Mature: 32772

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKRWLALALFLGVALLVVGLGRLTASPPAQGPWRETTLYGQGEKVLLLELLGEIPSGK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHCCCCCCH
ALERFLSQVRQAREDEGVRAVVLYVESPGGGVTETEALHRALRALAQEKPLVASLGRVAA
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
SGGYYVATAAREILVPPTAVTGSIGVVGYLPQVGELLAKVGVRVEVLKEGRLKDMASPLR
CCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHCCCHHHHHCCCC
PLTPEEREVVQGLLREAYELFVQRVAEGRGMPREKVLALADGRIYSGKQAVALGLADREG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCEEEEECCCCCC
YLEDAARRAAELAGLKAFRLVRYTRPKGLLEGLWGEEVPWAQGLLQARFRVEYRYLGGGL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
W
C
>Mature Secondary Structure
MNRKRWLALALFLGVALLVVGLGRLTASPPAQGPWRETTLYGQGEKVLLLELLGEIPSGK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHCCCCCCH
ALERFLSQVRQAREDEGVRAVVLYVESPGGGVTETEALHRALRALAQEKPLVASLGRVAA
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
SGGYYVATAAREILVPPTAVTGSIGVVGYLPQVGELLAKVGVRVEVLKEGRLKDMASPLR
CCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHCCCHHHHHCCCC
PLTPEEREVVQGLLREAYELFVQRVAEGRGMPREKVLALADGRIYSGKQAVALGLADREG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCEEEEECCCCCC
YLEDAARRAAELAGLKAFRLVRYTRPKGLLEGLWGEEVPWAQGLLQARFRVEYRYLGGGL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
W
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10455123 [H]