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The map label for this gene is nadC [H]

Identifier: 55980954

GI number: 55980954

Start: 928331

End: 929191

Strand: Reverse

Name: nadC [H]

Synonym: TTHA0985

Alternate gene names: 55980954

Gene position: 929191-928331 (Counterclockwise)

Preceding gene: 55980957

Following gene: 55980953

Centisome position: 50.23

GC content: 72.47

Gene sequence:

>861_bases
ATGGGGGGCGTGGTCGGGGAGGCGCTTTGGCAAGGCGGCTTGGAAGAGGCCCTGAGGGCCTGGCTTCGGGAGGACCTGGG
GCAGGGGGACCTCACGAGCCTTTTGGTGGTTCCGGAGGACCTCGAGGGCGAGGCCGTGATCCTCGCCAAGGAGGGGGGCG
TCCTCGCGGGGCTTTGGGTGGCGGAGCGGGTCTTCGCCCTCGCGGACCCGCGCACCGCCTTCACCCCCCTGGTGGCGGAG
GGGGCGAGGGTGGCGGAGGGGACGGAGGTGGCCCGGGTCCGGGGGCCCTTGCGGGGCATCCTCGCCGGGGAGAGGCTCGC
CCTCAACCTCCTGCAGAGGCTTTCGGGAATCGCCACCCTGACCCGGGCCTACGTGGAGGCCCTCGCGGGCACCAAGGCCC
AGATCCTGGACACCCGCAAGACCACCCCGGGGCTTCGCGCCCTGGAGAAGTACGCCGTGCGGGTGGGCGGGGGGAGGAAC
CACCGCTATGGCCTCTTTGACGGGATCCTCCTCAAGGAGAACCACGTCCGGGCGGCGGGGGGCGTGGGCGAGGCGGTGCG
GCGGGCCAAGGCCCGCGCCCCCCACTACCTCAAGGTGGAGGTGGAGGTGCGAAGCCTGGAGGAGCTGGAGGAGGCCCTAG
AAGCCGGGGCCGACCTCATCCTCCTGGACAACTTCCCCCTCGAGGCCCTCCGGGAGGCGGTGCGCCGCGTGGGGGGAAGG
GTTCCCCTGGAGGCGAGCGGGAACATGACCCTGGAAAGGGCGAAGGCGGCGGCGGAGGCCGGGGTGGACTACGTCTCCGT
GGGGGCCCTCACCCACTCGGCCAAGGCCCTGGACCTCTCCCTCCTGGTGGTGCGTCCATGA

Upstream 100 bases:

>100_bases
GCATGGGCGAGGAGGTAGGGGCTTCTTGCGGCCTTTAGGCGGTTTCCCATCCCCTCCAGGCTAGGGCGGGAGGCCGAAGG
GGAAAAGCCTCCTCCTTACA

Downstream 100 bases:

>100_bases
GGGCGTGGAGGCGGTTCGGGCCCTGGTCCACCACCTCAGGAGGCCCCGCATAATGGGTAGGATGCGTGGGGAAGCCCTGG
CGCAAGAGGTCCTCAGGCTC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MGGVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDLEGEAVILAKEGGVLAGLWVAERVFALADPRTAFTPLVAE
GARVAEGTEVARVRGPLRGILAGERLALNLLQRLSGIATLTRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRN
HRYGLFDGILLKENHVRAAGGVGEAVRRAKARAPHYLKVEVEVRSLEELEEALEAGADLILLDNFPLEALREAVRRVGGR
VPLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSLLVVRP

Sequences:

>Translated_286_residues
MGGVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDLEGEAVILAKEGGVLAGLWVAERVFALADPRTAFTPLVAE
GARVAEGTEVARVRGPLRGILAGERLALNLLQRLSGIATLTRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRN
HRYGLFDGILLKENHVRAAGGVGEAVRRAKARAPHYLKVEVEVRSLEELEEALEAGADLILLDNFPLEALREAVRRVGGR
VPLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSLLVVRP
>Mature_285_residues
GGVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDLEGEAVILAKEGGVLAGLWVAERVFALADPRTAFTPLVAEG
ARVAEGTEVARVRGPLRGILAGERLALNLLQRLSGIATLTRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRNH
RYGLFDGILLKENHVRAAGGVGEAVRRAKARAPHYLKVEVEVRSLEELEEALEAGADLILLDNFPLEALREAVRRVGGRV
PLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSLLVVRP

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=267, Percent_Identity=43.0711610486891, Blast_Score=171, Evalue=6e-43,
Organism=Escherichia coli, GI1786299, Length=266, Percent_Identity=49.2481203007519, Blast_Score=210, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6321162, Length=286, Percent_Identity=36.3636363636364, Blast_Score=161, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30423; Mature: 30292

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDLEGEAVILAKEGGVLAGLWV
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCEEEHHHH
AERVFALADPRTAFTPLVAEGARVAEGTEVARVRGPLRGILAGERLALNLLQRLSGIATL
HHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
TRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRNHRYGLFDGILLKENHVRAAG
HHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCC
GVGEAVRRAKARAPHYLKVEVEVRSLEELEEALEAGADLILLDNFPLEALREAVRRVGGR
CHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCC
VPLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSLLVVRP
CCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCEEEEEEEEECC
>Mature Secondary Structure 
GGVVGEALWQGGLEEALRAWLREDLGQGDLTSLLVVPEDLEGEAVILAKEGGVLAGLWV
CCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCEEEHHHH
AERVFALADPRTAFTPLVAEGARVAEGTEVARVRGPLRGILAGERLALNLLQRLSGIATL
HHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
TRAYVEALAGTKAQILDTRKTTPGLRALEKYAVRVGGGRNHRYGLFDGILLKENHVRAAG
HHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCC
GVGEAVRRAKARAPHYLKVEVEVRSLEELEEALEAGADLILLDNFPLEALREAVRRVGGR
CHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCC
VPLEASGNMTLERAKAAAEAGVDYVSVGALTHSAKALDLSLLVVRP
CCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]