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The map label for this gene is dtd

Identifier: 55980918

GI number: 55980918

Start: 895149

End: 895607

Strand: Reverse

Name: dtd

Synonym: TTHA0949

Alternate gene names: 55980918

Gene position: 895607-895149 (Counterclockwise)

Preceding gene: 55980919

Following gene: 55980917

Centisome position: 48.42

GC content: 68.63

Gene sequence:

>459_bases
GTGCGGGCGGTGGTGCAGCGGGTCTCCGAGGCCTTCGTGGAGGTGGAGGGCGAGGTGGTGGGGAGGATCGGGCTGGGCCT
CCTCGTCCTCCTCGGGGTGGGCCAGAAGGACAGCCTCGAGGACGCCCTCTACCTCGCCCGCAAGATCGTCAACCTCCGGG
TCTTCCCCGACGCCCAGGACAAGATGAACCTCTCCCTTAAGGACGTGGGAGGGGAGGTGCTCCTGGTCAGCCAGTTCACC
CTCTACGCCGACACCCGGAAGGGCAACCGCCCCTCCTTCGCCAAGGCCGCCCCGCCCGACCAAGGCAAGCGGCTCTACGA
GGCGGCCCTCGAGGCCTTCCTCCAGCAAGGGGTGCACGTGGAGACCGGGGTCTACGGGGCCCACATGCGGGTCCACCTGG
TAAACGATGGCCCCGTCACCCTCTTCCTGGACTCGGAGGAACGCTTCCGCCCACGCTGA

Upstream 100 bases:

>100_bases
GGGGGTTGAGGTCCTGGGGGTCCTCCCCGCCGGAGCGGCGGTGAGCGTGCACACGGGGCCCGGCACGGTGGCGGCCTTCG
CCGGGCCCAGGAGGTGAGGC

Downstream 100 bases:

>100_bases
GGGGCGCCGTTTGACCTTTGCCCCCGTTACCGGGTAAACTAGCAGGAACGCCCCACTCGGCGTGGAGTAAAAGATGGAAA
AGATTCAACCCAAAGACTGG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MRAVVQRVSEAFVEVEGEVVGRIGLGLLVLLGVGQKDSLEDALYLARKIVNLRVFPDAQDKMNLSLKDVGGEVLLVSQFT
LYADTRKGNRPSFAKAAPPDQGKRLYEAALEAFLQQGVHVETGVYGAHMRVHLVNDGPVTLFLDSEERFRPR

Sequences:

>Translated_152_residues
MRAVVQRVSEAFVEVEGEVVGRIGLGLLVLLGVGQKDSLEDALYLARKIVNLRVFPDAQDKMNLSLKDVGGEVLLVSQFT
LYADTRKGNRPSFAKAAPPDQGKRLYEAALEAFLQQGVHVETGVYGAHMRVHLVNDGPVTLFLDSEERFRPR
>Mature_152_residues
MRAVVQRVSEAFVEVEGEVVGRIGLGLLVLLGVGQKDSLEDALYLARKIVNLRVFPDAQDKMNLSLKDVGGEVLLVSQFT
LYADTRKGNRPSFAKAAPPDQGKRLYEAALEAFLQQGVHVETGVYGAHMRVHLVNDGPVTLFLDSEERFRPR

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=148, Percent_Identity=43.9189189189189, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=52.4475524475524, Blast_Score=150, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=46.3576158940397, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319982, Length=151, Percent_Identity=38.4105960264901, Blast_Score=104, Evalue=6e-24,
Organism=Drosophila melanogaster, GI281361569, Length=150, Percent_Identity=44, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_THET2 (Q72K35)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004558.1
- ProteinModelPortal:   Q72K35
- SMR:   Q72K35
- STRING:   Q72K35
- GeneID:   2775942
- GenomeReviews:   AE017221_GR
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q72K35
- ProtClustDB:   PRK05273
- BioCyc:   TTHE262724:TT_C0583-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16792; Mature: 16792

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVQRVSEAFVEVEGEVVGRIGLGLLVLLGVGQKDSLEDALYLARKIVNLRVFPDAQD
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCCCCH
KMNLSLKDVGGEVLLVSQFTLYADTRKGNRPSFAKAAPPDQGKRLYEAALEAFLQQGVHV
HCCEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
ETGVYGAHMRVHLVNDGPVTLFLDSEERFRPR
ECCEEECEEEEEEECCCCEEEEECCHHCCCCC
>Mature Secondary Structure
MRAVVQRVSEAFVEVEGEVVGRIGLGLLVLLGVGQKDSLEDALYLARKIVNLRVFPDAQD
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCCCCH
KMNLSLKDVGGEVLLVSQFTLYADTRKGNRPSFAKAAPPDQGKRLYEAALEAFLQQGVHV
HCCEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
ETGVYGAHMRVHLVNDGPVTLFLDSEERFRPR
ECCEEECEEEEEEECCCCEEEEECCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA