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The map label for this gene is psaA [H]

Identifier: 55980565

GI number: 55980565

Start: 562096

End: 562941

Strand: Reverse

Name: psaA [H]

Synonym: TTHA0596

Alternate gene names: 55980565

Gene position: 562941-562096 (Counterclockwise)

Preceding gene: 55980567

Following gene: 55980564

Centisome position: 30.43

GC content: 71.75

Gene sequence:

>846_bases
ATGCGCGCCCTAGCCCTCCTTCCCTGGCTCCTCGCCGCCGCCTTGGCCCAGGTCCAGGTGGCGGCCACCACCCCCATCCT
CGCCGACCTCGTCCGGCAGGTGGGGGGAAATCGGGTGGCGGCGGTGGCGGTCGTCCCCCCGGGGGCCGACCCCCACACCT
TTGAGCCCACCCCCTCCGTGGCCCAGGCCTTAAGCCAGACCCGCCTCCTCTTCGCCAACGGGCTCGGCCTCGAGCCCTAC
CTGCCCAAGCTCCAGGCCCTCCTCCCCCAAAACGCCCGGGTGGTCCTCCTCGGGGAGGGGCAGCCGGACCTGATCTGCGG
GGAGGACCATGCGGAGGAGGACCACGGCCACGGCCCCTGCGACCCCCACCTCTGGCTGGACCCCGCCTACGCCGTCCGCT
ACGCCGAGCGGATCCTCGAGGCCCTCGCCGCCTTGGACCCCGGGGGCCGGGACCTCTACCGGGCCAACCTGGAGCGCTTC
AAAAAGGAGGTGGAGGCCCTGGACCGGGCCTATAGGGCCTGCGGGCTTAAGGGAACGAAGGTGGTGGTCCAGCACGACGC
CTTCCGCTACTTCGCCAGGCGGTACGGCCTGGAGGTGGTGGGGGTCTTGAGCCAGGGCGGGGCCCAGGAGGTGGGGAGCC
GGAGCTTCCTCGCCCTCCTGGAGAAGGCCAAGAGGGAGGGGGTCAGGCTCGTCCTCGCCGAGCCCCAGTTCCAGGGCAAG
GCCCTGAAGACCCTGGCCGAGGCCATAGGAGCCCGGGTGGCGGTCCTCTACACCGACACCCTGGACGCCCGGGTGAGGAC
CTACCTGGACCTCCTGCGCCACAACCTGCGGGCCCTCTGCCCATAA

Upstream 100 bases:

>100_bases
CTCCAGCCGCATCGCCCCCCCAGGCTACGGGGAAGGCCCCGGGGGGCGCAACCGCGGGGGGTTGACAAAGCGAGTTTGAT
AATCCAATATCACTTTTGCC

Downstream 100 bases:

>100_bases
TGGAGGCATGGGCTTCCAAGAGGTTTACGGCGTCCTGCCCCAGGCCAGCGCCCAGGCCCCCGGCCGGGTGAACCTCCTGG
GGGAGCACACGGACTACCAG

Product: ABC transporter substrate-binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: Pneumococcal surface adhesin A [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MRALALLPWLLAAALAQVQVAATTPILADLVRQVGGNRVAAVAVVPPGADPHTFEPTPSVAQALSQTRLLFANGLGLEPY
LPKLQALLPQNARVVLLGEGQPDLICGEDHAEEDHGHGPCDPHLWLDPAYAVRYAERILEALAALDPGGRDLYRANLERF
KKEVEALDRAYRACGLKGTKVVVQHDAFRYFARRYGLEVVGVLSQGGAQEVGSRSFLALLEKAKREGVRLVLAEPQFQGK
ALKTLAEAIGARVAVLYTDTLDARVRTYLDLLRHNLRALCP

Sequences:

>Translated_281_residues
MRALALLPWLLAAALAQVQVAATTPILADLVRQVGGNRVAAVAVVPPGADPHTFEPTPSVAQALSQTRLLFANGLGLEPY
LPKLQALLPQNARVVLLGEGQPDLICGEDHAEEDHGHGPCDPHLWLDPAYAVRYAERILEALAALDPGGRDLYRANLERF
KKEVEALDRAYRACGLKGTKVVVQHDAFRYFARRYGLEVVGVLSQGGAQEVGSRSFLALLEKAKREGVRLVLAEPQFQGK
ALKTLAEAIGARVAVLYTDTLDARVRTYLDLLRHNLRALCP
>Mature_281_residues
MRALALLPWLLAAALAQVQVAATTPILADLVRQVGGNRVAAVAVVPPGADPHTFEPTPSVAQALSQTRLLFANGLGLEPY
LPKLQALLPQNARVVLLGEGQPDLICGEDHAEEDHGHGPCDPHLWLDPAYAVRYAERILEALAALDPGGRDLYRANLERF
KKEVEALDRAYRACGLKGTKVVVQHDAFRYFARRYGLEVVGVLSQGGAQEVGSRSFLALLEKAKREGVRLVLAEPQFQGK
ALKTLAEAIGARVAVLYTDTLDARVRTYLDLLRHNLRALCP

Specific function: Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=292, Percent_Identity=24.6575342465753, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 30543; Mature: 30543

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALALLPWLLAAALAQVQVAATTPILADLVRQVGGNRVAAVAVVPPGADPHTFEPTPSV
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHH
AQALSQTRLLFANGLGLEPYLPKLQALLPQNARVVLLGEGQPDLICGEDHAEEDHGHGPC
HHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCC
DPHLWLDPAYAVRYAERILEALAALDPGGRDLYRANLERFKKEVEALDRAYRACGLKGTK
CCCCEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVVQHDAFRYFARRYGLEVVGVLSQGGAQEVGSRSFLALLEKAKREGVRLVLAEPQFQGK
EEEEHHHHHHHHHHHCCHHEEEHHCCCHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCCH
ALKTLAEAIGARVAVLYTDTLDARVRTYLDLLRHNLRALCP
HHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRALALLPWLLAAALAQVQVAATTPILADLVRQVGGNRVAAVAVVPPGADPHTFEPTPSV
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHH
AQALSQTRLLFANGLGLEPYLPKLQALLPQNARVVLLGEGQPDLICGEDHAEEDHGHGPC
HHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCC
DPHLWLDPAYAVRYAERILEALAALDPGGRDLYRANLERFKKEVEALDRAYRACGLKGTK
CCCCEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVVQHDAFRYFARRYGLEVVGVLSQGGAQEVGSRSFLALLEKAKREGVRLVLAEPQFQGK
EEEEHHHHHHHHHHHCCHHEEEHHCCCHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCCH
ALKTLAEAIGARVAVLYTDTLDARVRTYLDLLRHNLRALCP
HHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8945574; 9767595; 11463916; 9379902 [H]