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The map label for this gene is galK [H]

Identifier: 55980564

GI number: 55980564

Start: 561045

End: 562088

Strand: Reverse

Name: galK [H]

Synonym: TTHA0595

Alternate gene names: 55980564

Gene position: 562088-561045 (Counterclockwise)

Preceding gene: 55980565

Following gene: 55980562

Centisome position: 30.39

GC content: 72.99

Gene sequence:

>1044_bases
ATGGGCTTCCAAGAGGTTTACGGCGTCCTGCCCCAGGCCAGCGCCCAGGCCCCCGGCCGGGTGAACCTCCTGGGGGAGCA
CACGGACTACCAGGAAGGCTACGTCCTCCCCACCCCGATCCCCTACTTCACCCAGGTGGAGGCCGCCCCCCTCGAGGGGG
CGGTGGAGGCCTTCAGCGAGAACCTGGGGGAGCTCCGGGCCCGCCCCCTCTCCTCCCCGCCCCAAGGGGACTTCCTGGAC
TACCTCCTCGGGGTGGTCCGGGCCCTCCGGGAGGCCGGGCACGAGGTGGCGGGGGCCAGGTTCTACGTTCGCAGCGACCT
CCCCATGGGGGCGGGCCTCTCCAGCTCCGCCGCCCTCGAGGTGGCGGCCCTCAGGGCCCTCCGCACCCTCTACCGCCTCC
CCTTGAGCGACCTGGAGGTGGCCCGCCTCGCCCAGAAGGCGGAGGTGGAGTACGTGGGGGTCCGGTGCGGGATCATGGAC
CAGATGGCGGCAAGCCTGGGCCAGCCGGGGCAGGCCCTCTTCCTGGACACCCGGACCCTGGCCTACGAGAACCTTCCCCT
TCCCCCGGGGGTGCGGGTGGCTGTCCTGGACCTCGGGCTTGGGCGCAGGCTGGCGGAGGCCGGGTACAACCGGCGCCGCC
AGGAGGCGGAGGAGGCGGCCAAGAGGCTCGGGGTGCGGTCCCTTAGGGACGTGGCCGACCTCTGCCTGGTGGAAAGCCTC
CCTTCGCCCCTGGACCGGCGGGCCCGGCACGTGGTGAGCGAGAACCTCAGGGTCCTCCGGGGGGTGGAGGCCCTAAGGCG
GCAAGACGCCCGGGCCTTCGGGGAGCTTATGACGCAAAGCCACCGCTCCCTCGCCCAAGACTACGAGGTGAGCCTGCCCG
AGCTGGACGCCCTGGTGGAGGAGGCCCTGCGGGCCGGGGCCTACGGGGCCAAGCTCACGGGGGCGGGCTTCGGCGGGGCC
GTGGTGGCCCTGGTGGCCGAAAGCCGCTTCCCCGCCTTCAGGGAGGCCCTGGCCCGGCGCTTCCCCGACCTCAAGGTCCT
CTAA

Upstream 100 bases:

>100_bases
CGGGTGGCGGTCCTCTACACCGACACCCTGGACGCCCGGGTGAGGACCTACCTGGACCTCCTGCGCCACAACCTGCGGGC
CCTCTGCCCATAATGGAGGC

Downstream 100 bases:

>100_bases
ACCGAGGGGAAGGCGAAGGCCTGGTAGCCCAGCTCGGCCACGGCGAACCAGCGGAAGACCTCCTCCCGGAAGGCCCAGTA
GGCGGTGTAGACCCGGCGGT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MGFQEVYGVLPQASAQAPGRVNLLGEHTDYQEGYVLPTPIPYFTQVEAAPLEGAVEAFSENLGELRARPLSSPPQGDFLD
YLLGVVRALREAGHEVAGARFYVRSDLPMGAGLSSSAALEVAALRALRTLYRLPLSDLEVARLAQKAEVEYVGVRCGIMD
QMAASLGQPGQALFLDTRTLAYENLPLPPGVRVAVLDLGLGRRLAEAGYNRRRQEAEEAAKRLGVRSLRDVADLCLVESL
PSPLDRRARHVVSENLRVLRGVEALRRQDARAFGELMTQSHRSLAQDYEVSLPELDALVEEALRAGAYGAKLTGAGFGGA
VVALVAESRFPAFREALARRFPDLKVL

Sequences:

>Translated_347_residues
MGFQEVYGVLPQASAQAPGRVNLLGEHTDYQEGYVLPTPIPYFTQVEAAPLEGAVEAFSENLGELRARPLSSPPQGDFLD
YLLGVVRALREAGHEVAGARFYVRSDLPMGAGLSSSAALEVAALRALRTLYRLPLSDLEVARLAQKAEVEYVGVRCGIMD
QMAASLGQPGQALFLDTRTLAYENLPLPPGVRVAVLDLGLGRRLAEAGYNRRRQEAEEAAKRLGVRSLRDVADLCLVESL
PSPLDRRARHVVSENLRVLRGVEALRRQDARAFGELMTQSHRSLAQDYEVSLPELDALVEEALRAGAYGAKLTGAGFGGA
VVALVAESRFPAFREALARRFPDLKVL
>Mature_346_residues
GFQEVYGVLPQASAQAPGRVNLLGEHTDYQEGYVLPTPIPYFTQVEAAPLEGAVEAFSENLGELRARPLSSPPQGDFLDY
LLGVVRALREAGHEVAGARFYVRSDLPMGAGLSSSAALEVAALRALRTLYRLPLSDLEVARLAQKAEVEYVGVRCGIMDQ
MAASLGQPGQALFLDTRTLAYENLPLPPGVRVAVLDLGLGRRLAEAGYNRRRQEAEEAAKRLGVRSLRDVADLCLVESLP
SPLDRRARHVVSENLRVLRGVEALRRQDARAFGELMTQSHRSLAQDYEVSLPELDALVEEALRAGAYGAKLTGAGFGGAV
VALVAESRFPAFREALARRFPDLKVL

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=351, Percent_Identity=41.3105413105413, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI48527957, Length=404, Percent_Identity=28.4653465346535, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4503897, Length=404, Percent_Identity=28.4653465346535, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1786972, Length=351, Percent_Identity=37.6068376068376, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71989053, Length=387, Percent_Identity=32.2997416020672, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6319494, Length=112, Percent_Identity=41.0714285714286, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=196, Percent_Identity=30.1020408163265, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24661292, Length=402, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355577, Length=402, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24661285, Length=402, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 37674; Mature: 37542

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFQEVYGVLPQASAQAPGRVNLLGEHTDYQEGYVLPTPIPYFTQVEAAPLEGAVEAFSE
CCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCHHCCCCCCHHHHHHHHHH
NLGELRARPLSSPPQGDFLDYLLGVVRALREAGHEVAGARFYVRSDLPMGAGLSSSAALE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCCCCCCCHHHHH
VAALRALRTLYRLPLSDLEVARLAQKAEVEYVGVRCGIMDQMAASLGQPGQALFLDTRTL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHCCCCCEEEEEHHHH
AYENLPLPPGVRVAVLDLGLGRRLAEAGYNRRRQEAEEAAKRLGVRSLRDVADLCLVESL
HHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSPLDRRARHVVSENLRVLRGVEALRRQDARAFGELMTQSHRSLAQDYEVSLPELDALVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EALRAGAYGAKLTGAGFGGAVVALVAESRFPAFREALARRFPDLKVL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GFQEVYGVLPQASAQAPGRVNLLGEHTDYQEGYVLPTPIPYFTQVEAAPLEGAVEAFSE
CHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCHHCCCCCCHHHHHHHHHH
NLGELRARPLSSPPQGDFLDYLLGVVRALREAGHEVAGARFYVRSDLPMGAGLSSSAALE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCCCCCCCHHHHH
VAALRALRTLYRLPLSDLEVARLAQKAEVEYVGVRCGIMDQMAASLGQPGQALFLDTRTL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHCCCCCEEEEEHHHH
AYENLPLPPGVRVAVLDLGLGRRLAEAGYNRRRQEAEEAAKRLGVRSLRDVADLCLVESL
HHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSPLDRRARHVVSENLRVLRGVEALRRQDARAFGELMTQSHRSLAQDYEVSLPELDALVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EALRAGAYGAKLTGAGFGGAVVALVAESRFPAFREALARRFPDLKVL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA